Hsiu-Mei Hsieh

2024

Hyperbaric Oxygen Therapy Attenuated the Motor Coordination and Cognitive Impairment of Polyglutamine Spinocerebellar Ataxia SCA17 Mice

Chiang, M. K., Lin, T. C., Lin, K. H., Chang, Y. C., Hsieh-Li, H. M. & Lai, D. M., 2024 4月, 於: Cerebellum. 23, 2, p. 401-417 17 p.

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3 引文斯高帕斯（Scopus）

2023

A Neuroprotective Action of Quercetin and Apigenin through Inhibiting Aggregation of Aβ and Activation of TRKB Signaling in a Cellular Experiment

Chiu, Y. J., Teng, Y. S., Chen, C. M., Sun, Y. C., Hsieh-Li, H. M., Chang, K. H. & Lee-Chen, G. J., 2023 5月, 於: Biomolecules and Therapeutics. 31, 3, p. 285-297 13 p.

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10 引文斯高帕斯（Scopus）

Virtual Screening and Testing of GSK-3 Inhibitors Using Human SH-SY5Y Cells Expressing Tau Folding Reporter and Mouse Hippocampal Primary Culture under Tau Cytotoxicity

Lin, C. H., Hsieh, Y. S., Sun, Y. C., Huang, W. H., Chen, S. L., Weng, Z. K., Lin, T. H., Wu, Y. R., Chang, K. H., Huang, H. J., Lee, G. C., Hsieh-Li, H. M. & Lee-Chen, G. J., 2023, 於: Biomolecules and Therapeutics. 31, 1, p. 127-138 12 p.

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7 引文斯高帕斯（Scopus）

2022

Novel TRKB agonists activate TRKB and downstream ERK and AKT signaling to protect Aβ-GFP SH-SY5Y cells against Aβ toxicity

Chiu, Y. J., Lin, T. H., Chang, K. H., Lin, W., Hsieh-Li, H. M., Su, M. T., Chen, C. M., Sun, Y. C. & Lee-Chen, G. J., 2022, 於: Aging. 14, 18, p. 7568-7586 19 p.

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11 引文斯高帕斯（Scopus）

Secreted Neutrophil Gelatinase-Associated Lipocalin Shows Stronger Ability to Inhibit Cyst Enlargement of ADPKD Cells Compared with Nonsecreted Form

Chuang, H. Y., Jeng, W. Y., Wang, E., Jiang, S. T., Hsu, C. M., Hsieh-Li, H. M. & Chiou, Y. Y., 2022 2月 1, 於: Cells. 11, 3, 483.

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3 引文斯高帕斯（Scopus）

53 下載 (Pure)

Survival Motor Neuron Enhances Pluripotent Gene Expression and Facilitates Cell Reprogramming

Chang, W. F., Lin, T. Y., Peng, M., Chang, C. C., Xu, J., Hsieh-Li, H. M., Liu, J. L. & Sung, L. Y., 2022 11月, 於: Stem Cells and Development. 31, 21-22, p. 696-705 10 p.

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2 引文斯高帕斯（Scopus）

2021

Effects of survival motor neuron protein on germ cell development in mouse and human

Chang, W. F., Peng, M., Hsu, J., Xu, J., Cho, H. C., Hsieh-Li, H. M., Liu, J. L., Lu, C. H. & Sung, L. Y., 2021 1月 2, 於: International journal of molecular sciences. 22, 2, p. 1-14 14 p., 661.

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5 引文斯高帕斯（Scopus）

Flavones 7,8-DHF, Quercetin, and Apigenin Against Tau Toxicity via Activation of TRKB Signaling in ΔK280 Tau_RD-DsRed SH-SY5Y Cells

Chiang, N. N., Lin, T. H., Teng, Y. S., Sun, Y. C., Chang, K. H., Lin, C. Y., Hsieh-Li, H. M., Su, M. T., Chen, C. M. & Lee-Chen, G. J., 2021 12月 15, 於: Frontiers in Aging Neuroscience. 13, 758895.

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21 引文斯高帕斯（Scopus）

Formulated Chinese Medicine Shaoyao Gancao Tang Reduces Nlrp1 And Nlrp3 In Alzheimer’S Disease Cell And Mouse Models For Neuroprotection And Cognitive Improvement

Chiu, Y. J., Lin, C. H., Lee, M. C., Hsieh-Li, H. M., Chen, C. M., Wu, Y. R., Chang, K. H. & Lee-Chen, G. J., 2021 6月 15, 於: Aging. 13, 11, p. 15620-15637 18 p.

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42 引文斯高帕斯（Scopus）

Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer’s disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis

Huang, H. J., Chen, J. L., Liao, J. F., Chen, Y. H., Chieu, M. W., Ke, Y. Y., Hsu, C. C., Tsai, Y. C. & Hsieh-Li, H. M., 2021 12月, 於: BMC Complementary Medicine and Therapies. 21, 1, 259.

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27 引文斯高帕斯（Scopus）

Multi-target effects of novel synthetic coumarin derivatives protecting aβ-gfp sh-sy5y cells against aβ toxicity

Huang, C. C., Chang, K. H., Chiu, Y. J., Chen, Y. R., Lung, T. H., Hsieh-Li, H. M., Su, M. T., Sun, Y. C., Chen, C. M., Lin, W. & Lee-Chen, G. J., 2021 11月, 於: Cells. 10, 11, 3095.

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13 引文斯高帕斯（Scopus）

Novel Synthetic Coumarin-Chalcone Derivative (E)-3-(3-(4-(Dimethylamino)Phenyl)Acryloyl)-4-Hydroxy-2 H -Chromen-2-One Activates CREB-Mediated Neuroprotection in A β and Tau Cell Models of Alzheimer's Disease

Chiu, Y. J., Lin, T. H., Chen, C. M., Lin, C. H., Teng, Y. S., Lin, C. Y., Sun, Y. C., Hsieh-Li, H. M., Su, M. T., Lee-Chen, G. J., Lin, W. & Chang, K. H., 2021, 於: Oxidative medicine and cellular longevity. 2021, 3058861.

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11 引文斯高帕斯（Scopus）

Prebiotic Lactulose Ameliorates the Cognitive Deficit in Alzheimer's Disease Mouse Model through Macroautophagy and Chaperone-Mediated Autophagy Pathways

Lee, Y. S., Lai, D. M., Huang, H. J., Lee-Chen, G. J., Chang, C. H., Hsieh-Li, H. M. & Lee, G. C., 2021 3月 3, 於: Journal of Agricultural and Food Chemistry. 69, 8, p. 2422-2437 16 p.

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55 引文斯高帕斯（Scopus）

2020

ERK activation precedes Purkinje cell loss in mice with Spinocerebellar ataxia type 17

Lin, C. W., Fan, C. H., Chang, Y. C. & Hsieh-Li, H. M., 2020 11月 1, 於: Neuroscience Letters. 738, 135337.

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4 引文斯高帕斯（Scopus）

Exploration of multi-target effects of 3-benzoyl-5-hydroxychromen-2-one in Alzheimer’s disease cell and mouse models

Lin, T. H., Chiu, Y. J., Lin, C. H., Lin, C. Y., Chao, C. Y., Chen, Y. C., Yang, S. M., Lin, W., Mei Hsieh-Li, H., Wu, Y. R., Chang, K. H., Lee-Chen, G. J. & Chen, C. M., 2020 7月 1, 於: Aging Cell. 19, 7, ACEL13169.

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14 引文斯高帕斯（Scopus）

Lactobacillus plantarum PS128 alleviates neurodegenerative progression in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse models of Parkinson's disease

Liao, J. F., Cheng, Y. F., You, S. T., Kuo, W. C., Huang, C. W., Chiou, J. J., Hsu, C. C., Hsieh-Li, H. M., Wang, S. & Tsai, Y. C., 2020 11月, 於: Brain, Behavior, and Immunity. 90, p. 26-46 21 p.

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102 引文斯高帕斯（Scopus）

LMDS-1, a potential TrkB receptor agonist provides a safe and neurotrophic effect for early-phase Alzheimer’s disease

Fan, C. H., Lin, C. W., Huang, H. J., Lee-Chen, G. J., Sun, Y. C., Lin, W., Chen, C. M., Chang, K. H., Su, M. T. & Hsieh-Li, H. M., 2020 10月 1, 於: Psychopharmacology. 237, 10, p. 3173-3190 18 p.

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15 引文斯高帕斯（Scopus）

Neuroimaging Spectrum at Pre-, Early, and Late Symptomatic Stages of SCA17 Mice

Chen, C. C., Yao, N. W., Lin, C. W., Su, W. S., Wu, C. T., Chang, C. & Hsieh-Li, H. M., 2020 8月 1, 於: Cerebellum. 19, 4, p. 487-500 14 p.

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3 引文斯高帕斯（Scopus）

Survival motor neuron protein participates in mouse germ cell development and spermatogonium maintenance

Chang, W. F., Xu, J., Lin, T. Y., Hsu, J., Hsieh-Li, H. M., Hwu, Y. M., Liu, J. L., Lu, C. H. & Sung, L. Y., 2020 2月 1, 於: International journal of molecular sciences. 21, 3, 794.

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10 引文斯高帕斯（Scopus）

Targeting Inflammation, PHA-767491 Shows a Broad Spectrum in Protein Aggregation Diseases

Chung, Y. H., Lin, C. W., Huang, H. Y., Chen, S. L., Huang, H. J., Sun, Y. C., Lee, G. C., Lee-Chen, G. J., Chang, Y. C. & Hsieh-Li, H. M., 2020 7月 1, 於: Journal of Molecular Neuroscience. 70, 7, p. 1140-1152 13 p.

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14 引文斯高帕斯（Scopus）

2019

Chronic low dose of AM404 ameliorates the cognitive impairment and pathological features in hyperglycemic 3xTg-AD mice

Huang, H. J., Chen, S. L., Huang, H. Y., Sun, Y. C., Lee, G. C., Lee-Chen, G. J., Hsieh-Li, H. M. & Su, M. T., 2019 2月 14, 於: Psychopharmacology. 236, 2, p. 763-773 11 p.

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15 引文斯高帕斯（Scopus）

Indole compound NC009-1 augments APOE and TRKA in Alzheimer's disease cell and mouse models for neuroprotection and cognitive improvement

Chen, Y. C., Chiu, Y. J., Lin, C. H., Hsu, W. C., Wu, J. L., Huang, C. H., Lin, C. W., Yao, C. F., Huang, H. J., Lo, Y. S., Chen, C. M., Wu, Y. R., Chang, K. H., Lee-Chen, G. J. & Hsieh-Li, H. M., 2019, 於: Journal of Alzheimer's Disease. 67, 2, p. 737-756 20 p.

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14 引文斯高帕斯（Scopus）

MGCD0103, a selective histone deacetylase inhibitor, coameliorates oligomeric Aβ_25-35-induced anxiety and cognitive deficits in a mouse model

Huang, H. J., Huang, H. Y. & Hsieh-Li, H. M., 2019 2月, 於: CNS Neuroscience and Therapeutics. 25, 2, p. 175-186 12 p.

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17 引文斯高帕斯（Scopus）

Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease

Chiu, Y. J., Hsieh, Y. H., Lin, T. H., Lee, G. C., Hsieh-Li, H. M., Sun, Y. C., Chen, C. M., Chang, K. H. & Lee-Chen, G. J., 2019 5月, 於: Neurochemistry International. 125, p. 175-186 12 p.

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18 引文斯高帕斯（Scopus）

Puerariae Radix Prevents Anxiety and Cognitive Deficits in Mice under Oligomeric Aβ-Induced Stress

Huang, H. J., Huang, C. Y., Lee, M., Lin, J. Y. & Hsieh-Li, H. M., 2019, 於: American Journal of Chinese Medicine. 47, 7, p. 1459-1481 23 p.

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21 引文斯高帕斯（Scopus）

Shaoyao Gancao Tang (SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models

Chen, C. M., Chen, W. L., Hung, C. T., Lin, T. H., Lee, M. C., Chen, I. C., Lin, C. H., Chao, C. Y., Wu, Y. R., Chang, K. H., Hsieh-Li, H. M. & Lee-Chen, G. J., 2019, 於: Aging. 11, 3, p. 986-1007 22 p.

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20 引文斯高帕斯（Scopus）

2018

Administration of Momordica charantia enhances the neuroprotection and reduces the side effects of LiCl in the treatment of Alzheimer’s disease

Huang, H. J., Chen, S. L., Chang, Y. T., Chyuan, J. H. & Hsieh-Li, H. M., 2018 12月, 於: Nutrients. 10, 12, 1888.

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30 引文斯高帕斯（Scopus）

The indole compound NC009-1 inhibits aggregation and promotes neurite outgrowth through enhancement of HSPB1 in SCA17 cells and ameliorates the behavioral deficits in SCA17 mice

Chen, C. M., Chen, W. L., Hung, C. T., Lin, T. H., Chao, C. Y., Lin, C. H., Wu, Y. R., Chang, K. H., Yao, C. F., Lee-Chen, G. J., Su, M. T. & Hsieh-Li, H. M., 2018 7月, 於: NeuroToxicology. 67, p. 259-269 11 p.

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19 引文斯高帕斯（Scopus）

2017

An Improved Drugs Screening System Reveals that Baicalein Ameliorates the Aβ/AMPA/NMDA-Induced Depolarization of Neurons

Lin, T. S., Tsai, H. J., Lee, C. H., Song, Y. Q., Huang, R. S., Hsieh-Li, H. M., Liang, M. C. & Lin, Y., 2017, 於: Journal of Alzheimer's Disease. 56, 3, p. 959-976 18 p.

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16 引文斯高帕斯（Scopus）

Investigation of the bindings of a class of inhibitors with GSK3β kinase using thermodynamic integration MD simulation and kinase assay

Hsu, C. J., Hsu, W. C., Lee, D. J., Liu, A. L., Chang, C. M., Shih, H. J., Huang, W. H., Lee-Chen, G. J., Hsieh-Li, H. M., Lee, G. C. & Sun, Y. C., 2017 8月 1, 於: Chemical Biology and Drug Design. 90, 2, p. 272-281 10 p.

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5 引文斯高帕斯（Scopus）

Overexpression of exogenous kidney-specific Ngal attenuates progressive cyst development and prolongs lifespan in a murine model of polycystic kidney disease

Wang, E., Chiou, Y. Y., Jeng, W. Y., Lin, H. K., Lin, H. H., Chin, H. J., Leo Wang, C. K., Yu, S. S., Tsai, S. C., Chiang, C. Y., Cheng, P. H., Lin, H. J., Jiang, S. T., Chiu, S. T. & Hsieh-Li, H. M., 2017 2月 1, 於: Kidney International. 91, 2, p. 412-422 11 p.

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7 引文斯高帕斯（Scopus）

The Potential of Indole/Indolylquinoline Compounds in Tau Misfolding Reduction by Enhancement of HSPB1

Chang, K. H., Lin, C. H., Chen, H. C., Huang, H. Y., Chen, S. L., Lin, T. H., Ramesh, C., Huang, C. C., Fung, H. C., Wu, Y. R., Huang, H. J., Lee-Chen, G. J., Hsieh-Li, H. M. & Yao, C. F., 2017 1月 1, 於: CNS Neuroscience and Therapeutics. 23, 1, p. 45-56 12 p.

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19 引文斯高帕斯（Scopus）

2016

Identifying GSK-3β kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays

Lin, C. H., Hsieh, Y. S., Wu, Y. R., Hsu, C. J., Chen, H. C., Huang, W. H., Chang, K. H., Hsieh-Li, H. M., Su, M. T., Sun, Y. C., Lee, G. C. & Lee-Chen, G. J., 2016 6月 30, 於: European Journal of Pharmaceutical Sciences. 89, p. 11-19 9 p.

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27 引文斯高帕斯（Scopus）

Novel lactulose and melibiose targeting autophagy to reduce polyQ aggregation in cell models of spinocerebellar ataxia

Lin, C. H., Wu, Y. R., Yang, J. M., Chen, W. L., Chao, C. Y., Chen, I. C., Lin, T. H., Wu, Y. C., Hsu, K. C., Chen, C. M., Lee, G. C., Hsieh-Li, H. M., Lee, C. M. & Lee-Chen, G. J., 2016 4月 1, 於: CNS and Neurological Disorders - Drug Targets. 15, 3, p. 351-359 9 p.

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24 引文斯高帕斯（Scopus）

Targeting the prodromal stage of spinocerebellar ataxia type 17 mice: G-CSF in the prevention of motor deficits via upregulating chaperone and autophagy levels

Chang, Y. C., Lin, C. W., Hsu, C. M., Lee-Chen, G. J., Su, M. T., Ro, L. S., Chen, C. M., Huang, H. J. & Hsieh-Li, H. M., 2016, 於: Brain Research. 1639, p. 132-148 17 p.

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14 引文斯高帕斯（Scopus）

The potential of synthetic indolylquinoline derivatives for Aβ aggregation reduction by chemical chaperone activity

Chang, K. H., Chiu, Y. J., Chen, S. L., Huang, C. H., Lin, C. H., Lin, T. H., Lee, C. M., Ramesh, C., Wu, C. H., Huang, C. C., Fung, H. C., Chen, Y. C., Lin, J. Y., Yao, C. F., Huang, H. J., Lee-Chen, G. J., Lee, M. C. & Hsieh-Li, H. M., 2016 2月 1, 於: Neuropharmacology. 101, p. 309-319 11 p.

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19 引文斯高帕斯（Scopus）

Treatment with a Ginkgo biloba extract, EGb 761, inhibits excitotoxicity in an animal model of spinocerebellar ataxia type 17

Huang, D. S., Lin, H. Y., Lee-Chen, G. J., Hsieh-Li, H. M., Wu, C. H. & Lin, J. Y., 2016 2月 18, 於: Drug Design, Development and Therapy. 10, p. 723-731 9 p.

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14 引文斯高帕斯（Scopus）

2015

Administration of NaHS Attenuates Footshock-Induced Pathologies and Emotional and Cognitive Dysfunction in Triple Transgenic Alzheimer’s Mice

Huang, H. J., Chen, S. L. & Hsieh-Li, H. M., 2015 11月 25, 於: Frontiers in Behavioral Neuroscience. 9, 312.

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17 引文斯高帕斯（Scopus）

SMN is required for the maintenance of embryonic stem cells and neuronal differentiation in mice

Chang, W. F., Xu, J., Chang, C. C., Yang, S. H., Li, H. Y., Hsieh-Li, H. M., Tsai, M. H., Wu, S. C., Cheng, W. T. K., Liu, J. L. & Sung, L. Y., 2015 5月 1, 於: Brain Structure and Function. 220, 3, p. 1539-1553 15 p.

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15 引文斯高帕斯（Scopus）

The potential of lactulose and melibiose, two novel trehalase-indigestible and autophagy-inducing disaccharides, for polyQ-mediated neurodegenerative disease treatment

Lee, G. C., Lin, C. H., Tao, Y. C., Yang, J. M., Hsu, K. C., Huang, Y. J., Huang, S. H., Kung, P. J., Chen, W. L., Wang, C. M., Wu, Y. R., Chen, C. M., Lin, J. Y., Hsieh-Li, H. M. & Lee-Chen, G. J., 2015 5月 1, 於: NeuroToxicology. 48, p. 120-130 11 p.

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25 引文斯高帕斯（Scopus）

Trehalose Attenuates the Gait Ataxia and Gliosis of Spinocerebellar Ataxia Type 17 Mice

Chen, Z. Z., Wang, C. M., Lee, G. C., Hsu, H. C., Wu, T. L., Lin, C. W., Ma, C. K., Lee-Chen, G. J., Huang, H. J. & Hsieh-Li, H. M., 2015 4月, 於: Neurochemical Research. 40, 4, p. 800-810 11 p.

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36 引文斯高帕斯（Scopus）

2014

Deactivation of TBP contributes to SCA17 pathogenesis

Hsu, T. C., Wang, C. K., Yang, C. Y., Lee, L. C., Hsieh-Li, H. M., Ro, L. S., Chen, C. M., Lee-Chen, G. J. & Su, M. T., 2014 12月 20, 於: Human molecular genetics. 23, 25, p. 6878-6893 16 p.

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26 引文斯高帕斯（Scopus）

Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models

Kung, P. J., Tao, Y. C., Hsu, H. C., Chen, W. L., Lin, T. H., Janreddy, D., Yao, C. F., Chang, K. H., Lin, J. Y., Su, M. T., Wu, C. H., Lee-Chen, G. J. & Hsieh-Li, H. M., 2014 10月 16, 於: Drug Design, Development and Therapy. 8, p. 1929-1939 11 p.

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14 引文斯高帕斯（Scopus）

Multifunctional effects of mangosteen pericarp on cognition in C57BL/6J and triple transgenic alzheimer's mice

Huang, H. J., Chen, W. L., Hsieh, R. H. & Hsieh-Li, H. M., 2014, 於: Evidence-based Complementary and Alternative Medicine. 2014, 813672.

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32 引文斯高帕斯（Scopus）

2013

Sodium vanadate combined with l-ascorbic acid delays disease progression, enhances motor performance, and ameliorates muscle atrophy and weakness in mice with spinal muscular atrophy

Liu, H. C., Ting, C. H., Wen, H. L., Tsai, L. K., Hsieh-Li, H. M., Li, H. & Lin-Chao, S., 2013 2月 14, 於: BMC Medicine. 11, 1, 38.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

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12 引文斯高帕斯（Scopus）

2012

Exendin-4 protected against cognitive dysfunction in hyperglycemic mice receiving an Intrahippocampal Lipopolysaccharide injection

Huang, H. J., Chen, Y. H., Liang, K. C., Jheng, Y. S., Jhao, J. J., Su, M. T., Lee-Chen, G. J. & Hsieh-Li, H. M., 2012 7月 23, 於: PloS one. 7, 7, e39656.

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61 引文斯高帕斯（Scopus）

Role of the CCAAT-binding protein NFY in SCA17 pathogenesis

Lee, L. C., Chen, C. M., Wang, H. C., Hsieh, H. H., Chiu, I. S., Su, M. T., Hsieh-Li, H. M., Wu, C. H., Lee, G. C., Lee-Chen, G. J. & Lin, J. Y., 2012 4月 17, 於: PloS one. 7, 4, e35302.

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26 引文斯高帕斯（Scopus）

The Spinal Muscular Atrophy Disease Protein SMN Is Linked to the Golgi Network

Ting, C. H., Wen, H. L., Liu, H. C., Hsieh-Li, H. M., Li, H. & Lin-Chao, S., 2012 12月 17, 於: PloS one. 7, 12, e51826.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

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33 引文斯高帕斯（Scopus）

Yang-Dan-Tang, identified from 15 Chinese herbal formulae, inhibits human lung cancer cell proliferation via cell cycle arrest

Wang, T. C., Fang, C. N., Shen, C. C., Wei, H. Y., Weng, Y. P., Lin, J. Y., Hsieh-Li, H. M. & Lee, C. Y., 2012, 於: Evidence-based Complementary and Alternative Medicine. 2012, 276032.

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4 引文斯高帕斯（Scopus）

2011

Human mesenchymal stem cells prolong survival and ameliorate motor deficit through trophic support in Huntington's disease mouse models

Lin, Y. T., Chern, Y., Shen, C. K. J., Wen, H. L., Chang, Y. C., Li, H., Cheng, T. H. & Hsieh-Li, H. M., 2011, 於: PloS one. 6, 8, e22924.

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93 引文斯高帕斯（Scopus）

謝 秀梅

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