Guey-Jen Lee-Chen

2023

Investigating Therapeutic Effects of Indole Derivatives Targeting Inflammation and Oxidative Stress in Neurotoxin-Induced Cell and Mouse Models of Parkinson’s Disease

Chiu, Y. J., Lin, C. H., Lin, C. Y., Yang, P. N., Lo, Y. S., Chen, Y. C., Chen, C. M., Wu, Y. R., Yao, C. F., Chang, K. H. & Lee-Chen, G. J., 2023 2月, 於: International journal of molecular sciences. 24, 3, 2642.

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Using ΔK280 Tau_RD Folding Reporter Cells to Screen TRKB Agonists as Alzheimer’s Disease Treatment Strategy

Weng, Z. K., Lin, T. H., Chang, K. H., Chiu, Y. J., Lin, C. H., Tseng, P. H., Sun, Y. C., Lin, W., Lee-Chen, G. J. & Chen, C. M., 2023 2月, 於: Biomolecules. 13, 2, 219.

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Virtual Screening and Testing of GSK-3 Inhibitors Using Human SH-SY5Y Cells Expressing Tau Folding Reporter and Mouse Hippocampal Primary Culture under Tau Cytotoxicity

Lin, C. H., Hsieh, Y. S., Sun, Y. C., Huang, W. H., Chen, S. L., Weng, Z. K., Lin, T. H., Wu, Y. R., Chang, K. H., Huang, H. J., Lee, G. C., Hsieh-Li, H. M. & Lee-Chen, G. J., 2023, 於: Biomolecules and Therapeutics. 31, 1, p. 127-138 12 p.

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2 引文斯高帕斯（Scopus）

2022

Isorhamnetin Attenuated the Release of Interleukin-6 from β -Amyloid-Activated Microglia and Mitigated Interleukin-6-Mediated Neurotoxicity

Wei, P. C., Lee-Chen, G. J., Chen, C. M., Chen, Y., Lo, Y. S. & Chang, K. H., 2022, 於: Oxidative medicine and cellular longevity. 2022, 3652402.

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1 引文斯高帕斯（Scopus）

Neuroprotective Action of Coumarin Derivatives through Activation of TRKB-CREB-BDNF Pathway and Reduction of Caspase Activity in Neuronal Cells Expressing Pro-Aggregated Tau Protein

Lin, T. H., Chang, K. H., Chiu, Y. J., Weng, Z. K., Sun, Y. C., Lin, W., Lee-Chen, G. J. & Chen, C. M., 2022 11月, 於: International journal of molecular sciences. 23, 21, 12734.

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1 引文斯高帕斯（Scopus）

Novel TRKB agonists activate TRKB and downstream ERK and AKT signaling to protect Aβ-GFP SH-SY5Y cells against Aβ toxicity

Chiu, Y. J., Lin, T. H., Chang, K. H., Lin, W., Hsieh-Li, H. M., Su, M. T., Chen, C. M., Sun, Y. C. & Lee-Chen, G. J., 2022, 於: Aging. 14, 18, p. 7568-7586 19 p.

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1 引文斯高帕斯（Scopus）

2021

Association of SOD2 p.V16A polymorphism with Parkinson's disease: A meta-analysis in Han Chinese

Wu, Y. R., Chang, K. H., Chao, C. Y., Lin, C. H., Chen, Y. C., Liu, T. W., Lee-Chen, G. J. & Chen, C. M., 2021 1月, 於: Journal of the Formosan Medical Association. 120, 1, p. 501-507 7 p.

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2 引文斯高帕斯（Scopus）

Flavones 7,8-DHF, Quercetin, and Apigenin Against Tau Toxicity via Activation of TRKB Signaling in ΔK280 Tau_RD-DsRed SH-SY5Y Cells

Chiang, N. N., Lin, T. H., Teng, Y. S., Sun, Y. C., Chang, K. H., Lin, C. Y., Hsieh-Li, H. M., Su, M. T., Chen, C. M. & Lee-Chen, G. J., 2021 12月 15, 於: Frontiers in Aging Neuroscience. 13, 758895.

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4 引文斯高帕斯（Scopus）

Formulated Chinese Medicine Shaoyao Gancao Tang Reduces Nlrp1 And Nlrp3 In Alzheimer’S Disease Cell And Mouse Models For Neuroprotection And Cognitive Improvement

Chiu, Y. J., Lin, C. H., Lee, M. C., Hsieh-Li, H. M., Chen, C. M., Wu, Y. R., Chang, K. H. & Lee-Chen, G. J., 2021 6月 15, 於: Aging. 13, 11, p. 15620-15637 18 p.

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15 引文斯高帕斯（Scopus）

Multi-target effects of novel synthetic coumarin derivatives protecting aβ-gfp sh-sy5y cells against aβ toxicity

Huang, C. C., Chang, K. H., Chiu, Y. J., Chen, Y. R., Lung, T. H., Hsieh-Li, H. M., Su, M. T., Sun, Y. C., Chen, C. M., Lin, W. & Lee-Chen, G. J., 2021 11月, 於: Cells. 10, 11, 3095.

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4 引文斯高帕斯（Scopus）

Novel Synthetic Coumarin-Chalcone Derivative (E)-3-(3-(4-(Dimethylamino)Phenyl)Acryloyl)-4-Hydroxy-2 H -Chromen-2-One Activates CREB-Mediated Neuroprotection in A β and Tau Cell Models of Alzheimer's Disease

Chiu, Y. J., Lin, T. H., Chen, C. M., Lin, C. H., Teng, Y. S., Lin, C. Y., Sun, Y. C., Hsieh-Li, H. M., Su, M. T., Lee-Chen, G. J., Lin, W. & Chang, K. H., 2021, 於: Oxidative medicine and cellular longevity. 2021, 3058861.

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3 引文斯高帕斯（Scopus）

Pathomechanism characterization and potential therapeutics identification for parkinson’s disease targeting neuroinflammation

Chen, C. M., Yen, C. Y., Chen, W. L., Lin, C. H., Wu, Y. R., Chang, K. H. & Lee-Chen, G. J., 2021 2月 1, 於: International journal of molecular sciences. 22, 3, p. 1-25 25 p., 1062.

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9 引文斯高帕斯（Scopus）

Prebiotic Lactulose Ameliorates the Cognitive Deficit in Alzheimer's Disease Mouse Model through Macroautophagy and Chaperone-Mediated Autophagy Pathways

Lee, Y. S., Lai, D. M., Huang, H. J., Lee-Chen, G. J., Chang, C. H., Hsieh-Li, H. M. & Lee, G-C., 2021 3月 3, 於: Journal of Agricultural and Food Chemistry. 69, 8, p. 2422-2437 16 p.

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22 引文斯高帕斯（Scopus）

2020

Exploration of multi-target effects of 3-benzoyl-5-hydroxychromen-2-one in Alzheimer’s disease cell and mouse models

Lin, T. H., Chiu, Y. J., Lin, C. H., Lin, C. Y., Chao, C. Y., Chen, Y. C., Yang, S. M., Lin, W., Mei Hsieh-Li, H., Wu, Y. R., Chang, K. H., Lee-Chen, G. J. & Chen, C. M., 2020 7月 1, 於: Aging Cell. 19, 7, ACEL13169.

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12 引文斯高帕斯（Scopus）

Genetic Analysis of EGLN1 C127S Variant in Taiwanese Parkinson's Disease

Chiang, H. L., Chen, C. M., Chen, Y. C., Chao, C. Y., Wu, Y. R. & Lee-Chen, G. J., 2020, 於: Parkinson's Disease. 2020, 9582317.

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Lactulose and Melibiose Attenuate MPTP-Induced Parkinson’s Disease in Mice by Inhibition of Oxidative Stress, Reduction of Neuroinflammation and Up-Regulation of Autophagy

Lin, C. H., Wei, P. C., Chen, C. M., Huang, Y. T., Lin, J. L., Lo, Y. S., Lin, J. L., Lin, C. Y., Wu, Y. R., Chang, K. H. & Lee-Chen, G. J., 2020 7月 24, 於: Frontiers in Aging Neuroscience. 12, 226.

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19 引文斯高帕斯（Scopus）

Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability

Chen, C. M., Lin, C. H., Wu, Y. R., Yen, C. Y., Huang, Y. T., Lin, J. L., Lin, C. Y., Chen, W. L., Chao, C. Y., Lee-Chen, G. J., Su, M. T. & Chang, K. H., 2020 5月 16, 於: Cells. 9, 5

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8 引文斯高帕斯（Scopus）

LMDS-1, a potential TrkB receptor agonist provides a safe and neurotrophic effect for early-phase Alzheimer’s disease

Fan, C. H., Lin, C. W., Huang, H. J., Lee-Chen, G. J., Sun, Y. C., Lin, W., Chen, C. M., Chang, K. H., Su, M. T. & Hsieh-Li, H. M., 2020 10月 1, 於: Psychopharmacology. 237, 10, p. 3173-3190 18 p.

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10 引文斯高帕斯（Scopus）

New Synthetic 3-Benzoyl-5-Hydroxy-2 H-Chromen-2-One (LM-031) Inhibits Polyglutamine Aggregation and Promotes Neurite Outgrowth through Enhancement of CREB, NRF2, and Reduction of AMPK α in SCA17 Cell Models

Chen, C. M., Chen, W. L., Yang, S. T., Lin, T. H., Yang, S. M., Lin, W., Chao, C. Y., Wu, Y. R., Chang, K. H. & Lee-Chen, G. J., 2020, 於: Oxidative medicine and cellular longevity. 2020, 3129497.

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4 引文斯高帕斯（Scopus）

Pathomechanism characterization and potential therapeutics identification for SCA3 targeting neuroinflammation

Chiu, Y. J., Lin, S. A., Chen, W. L., Lin, T. H., Lin, C. H., Yao, C. F., Lin, W., Wu, Y. R., Chang, K. H., Lee-Chen, G. J. & Chen, C. M., 2020 12月, 於: Aging. 12, 23, p. 23619-23646 28 p.

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7 引文斯高帕斯（Scopus）

Rare VPS35 A320V variant in Taiwanese Parkinson’s disease indicates disrupted CI-MPR sorting and impaired mitochondrial morphology

Wu, Y. R., Lin, C. H., Chao, C. Y., Chang, C. W., Chen, C. M. & Lee-Chen, G. J., 2020 11月, 於: Brain Sciences. 10, 11, p. 1-12 12 p., 0783.

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2 引文斯高帕斯（Scopus）

Targeting Inflammation, PHA-767491 Shows a Broad Spectrum in Protein Aggregation Diseases

Chung, Y. H., Lin, C. W., Huang, H. Y., Chen, S. L., Huang, H. J., Sun, Y. C., Lee, G-C., Lee-Chen, G. J., Chang, Y. C. & Hsieh-Li, H. M., 2020 7月 1, 於: Journal of Molecular Neuroscience. 70, 7, p. 1140-1152 13 p.

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9 引文斯高帕斯（Scopus）

2019

Chronic low dose of AM404 ameliorates the cognitive impairment and pathological features in hyperglycemic 3xTg-AD mice

Huang, H. J., Chen, S. L., Huang, H. Y., Sun, Y. C., Lee, G. C., Lee-Chen, G. J., Hsieh-Li, H. M. & Su, M. T., 2019 2月 14, 於: Psychopharmacology. 236, 2, p. 763-773 11 p.

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13 引文斯高帕斯（Scopus）

Indole compound NC009-1 augments APOE and TRKA in Alzheimer's disease cell and mouse models for neuroprotection and cognitive improvement

Chen, Y. C., Chiu, Y. J., Lin, C. H., Hsu, W. C., Wu, J. L., Huang, C. H., Lin, C. W., Yao, C. F., Huang, H. J., Lo, Y. S., Chen, C. M., Wu, Y. R., Chang, K. H., Lee-Chen, G. J. & Hsieh-Li, H. M., 2019, 於: Journal of Alzheimer's Disease. 67, 2, p. 737-756 20 p.

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10 引文斯高帕斯（Scopus）

Microbubble-facilitated ultrasound pulsation promotes direct α-synuclein gene delivery

Lin, C. J., Lin, C. Y., Lin, Y. T., Huang, C. Y., Wei, K. C., Chen, J. C., Lee-Chen, G. J. & Liu, H. L., 2019 9月 10, 於: Biochemical and Biophysical Research Communications. 517, 1, p. 77-83 7 p.

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4 引文斯高帕斯（Scopus）

Modeling Alzheimer’s Disease by Induced Pluripotent Stem Cells Carrying APP D678H Mutation

Chang, K. H., Lee-Chen, G. J., Huang, C. C., Lin, J. L., Chen, Y. J., Wei, P. C., Lo, Y. S., Yao, C. F., Kuo, M. W. & Chen, C. M., 2019 6月 1, 於: Molecular Neurobiology. 56, 6, p. 3972-3983 12 p.

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29 引文斯高帕斯（Scopus）

Multiple epigenetic biomarkers for evaluation of students' academic performance

Lee, L. C., Su, M. T., Cho, Y. C., Lee-Chen, G. J., Yeh, T. K. & Chang, C. Y., 2019 6月, 於: Genes, Brain and Behavior. 18, 5, e12559.

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2 引文斯高帕斯（Scopus）

Neuroprotection of Indole-Derivative Compound NC001-8 by the Regulation of the NRF2 Pathway in Parkinson's Disease Cell Models

Wei, P. C., Lee-Chen, G. J., Chen, C. M., Wu, Y. R., Chen, Y. J., Lin, J. L., Lo, Y. S., Yao, C. F. & Chang, K. H., 2019, 於: Oxidative medicine and cellular longevity. 2019, 5074367.

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14 引文斯高帕斯（Scopus）

Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease

Chiu, Y. J., Hsieh, Y. H., Lin, T. H., Lee, G-C., Hsieh-Li, H. M., Sun, Y. C., Chen, C. M., Chang, K. H. & Lee-Chen, G. J., 2019 5月, 於: Neurochemistry International. 125, p. 175-186 12 p.

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14 引文斯高帕斯（Scopus）

Pueraria lobata and Daidzein Reduce Cytotoxicity by Enhancing Ubiquitin-Proteasome System Function in SCA3-iPSC-Derived Neurons

Chen, I. C., Chang, K. H., Chen, Y. J., Chen, Y. C., Lee-Chen, G. J. & Chen, C. M., 2019, 於: Oxidative medicine and cellular longevity. 2019, 8130481.

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10 引文斯高帕斯（Scopus）

Shaoyao Gancao Tang (SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models

Chen, C. M., Chen, W. L., Hung, C. T., Lin, T. H., Lee, M. C., Chen, I. C., Lin, C. H., Chao, C. Y., Wu, Y. R., Chang, K. H., Hsieh-Li, H. M. & Lee-Chen, G. J., 2019, 於: Aging. 11, 3, p. 986-1007 22 p.

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12 引文斯高帕斯（Scopus）

Targeting Ubiquitin Proteasome Pathway with Traditional Chinese Medicine for Treatment of Spinocerebellar Ataxia Type 3

Chen, I. C., Chang, C. N., Chen, W. L., Lin, T. H., Chao, C. Y., Lin, C. H., Lin, H. Y., Cheng, M. L., Chiang, M. C., Lin, J. Y., Wu, Y. R., Lee-Chen, G. J. & Chen, C. M., 2019, 於: American Journal of Chinese Medicine. 47, 1, p. 63-95 33 p.

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8 引文斯高帕斯（Scopus）

2018

Chinese Herbal Medicine Glycyrrhiza inflata Reduces Aβ Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation

Chiu, Y. J., Lee, C. M., Lin, T. H., Lin, H. Y., Lee, S. Y., Mesri, M., Chang, K. H., Lin, J. Y., Lee-Chen, G. J. & Chen, C. M., 2018, 於: American Journal of Chinese Medicine. 46, 7, p. 1535-1549 15 p.

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8 引文斯高帕斯（Scopus）

Formulated Chinese medicine shaoyao gancao tang reduces tau aggregation and exerts neuroprotection through anti-oxidation and anti-inflammation

Chen, I. C., Lin, T. H., Hsieh, Y. H., Chao, C. Y., Wu, Y. R., Chang, K. H., Lee, M. C., Lee-Chen, G. J. & Chen, C. M., 2018, 於: Oxidative medicine and cellular longevity. 2018, 9595741.

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22 引文斯高帕斯（Scopus）

Genetic and functional characters of GRN p.T487I mutation in Taiwanese patients with atypical parkinsonian disorders

Chang, K. H., Lee, G. C., Huang, C. C., Kuo, H. C., Chen, C. M., Hsiao, Y. C., Hsu, H. C., Hsu, K. J., Lin, C. H., Chang, C. W., Lee-Chen, G. J. & Wu, Y. R., 2018 6月, 於: Parkinsonism and Related Disorders. 51, p. 61-66 6 p.

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6 引文斯高帕斯（Scopus）

Novel synthetic chalcone-coumarin hybrid for Aβ aggregation reduction, antioxidation, and neuroprotection

Lee, S. Y., Chiu, Y. J., Yang, S. M., Chen, C. M., Huang, C. C., Lee-Chen, G. J., Lin, W. & Chang, K. H., 2018 12月, 於: CNS Neuroscience and Therapeutics. 24, 12, p. 1286-1298 13 p.

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26 引文斯高帕斯（Scopus）

The indole compound NC009-1 inhibits aggregation and promotes neurite outgrowth through enhancement of HSPB1 in SCA17 cells and ameliorates the behavioral deficits in SCA17 mice

Chen, C. M., Chen, W. L., Hung, C. T., Lin, T. H., Chao, C. Y., Lin, C. H., Wu, Y. R., Chang, K. H., Yao, C. F., Lee-Chen, G. J., Su, M. T. & Hsieh-Li, H. M., 2018 7月, 於: NeuroToxicology. 67, p. 259-269 11 p.

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15 引文斯高帕斯（Scopus）

2017

Functional properties of LRRK2 mutations in Taiwanese Parkinson disease

Chang, K. H., Chen, C. M., Lin, C. H., Chang, W. T., Jiang, P. R., Hsiao, Y. C., Wu, Y. R. & Lee-Chen, G. J., 2017 3月 1, 於: Journal of the Formosan Medical Association. 116, 3, p. 197-204 8 p.

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1 引文斯高帕斯（Scopus）

Investigation of the bindings of a class of inhibitors with GSK3β kinase using thermodynamic integration MD simulation and kinase assay

Hsu, C. J., Hsu, W. C., Lee, D. J., Liu, A. L., Chang, C. M., Shih, H. J., Huang, W. H., Lee-Chen, G. J., Hsieh-Li, H. M., Lee, G-C. & Sun, Y. C., 2017 8月 1, 於: Chemical Biology and Drug Design. 90, 2, p. 272-281 10 p.

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5 引文斯高帕斯（Scopus）

The Potential of Indole/Indolylquinoline Compounds in Tau Misfolding Reduction by Enhancement of HSPB1

Chang, K. H., Lin, C. H., Chen, H. C., Huang, H. Y., Chen, S. L., Lin, T. H., Ramesh, C., Huang, C. C., Fung, H. C., Wu, Y. R., Huang, H. J., Lee-Chen, G. J., Hsieh-Li, H. M. & Yao, C. F., 2017 1月 1, 於: CNS Neuroscience and Therapeutics. 23, 1, p. 45-56 12 p.

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17 引文斯高帕斯（Scopus）

2016

Association of GCH1 and MIR4697, but not SIPA1L2 and VPS13C polymorphisms, with Parkinson's disease in Taiwan

Chen, C. M., Chen, Y. C., Chiang, M. C., Fung, H. C., Chang, K. H., Lee-Chen, G. J. & Wu, Y. R., 2016 3月 1, 於: Neurobiology of Aging. 39, p. 221.e1-221.e5

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12 引文斯高帕斯（Scopus）

Identifying GSK-3β kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays

Lin, C. H., Hsieh, Y. S., Wu, Y. R., Hsu, C. J., Chen, H. C., Huang, W. H., Chang, K. H., Hsieh-Li, H. M., Su, M. T., Sun, Y. C., Lee, G-C. & Lee-Chen, G. J., 2016 6月 30, 於: European Journal of Pharmaceutical Sciences. 89, p. 11-19 9 p.

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24 引文斯高帕斯（Scopus）

Impairment of proteasome and anti-oxidative pathways in the induced pluripotent stem cell model for sporadic Parkinson's disease

Chang, K. H., Lee-Chen, G. J., Wu, Y. R., Chen, Y. J., Lin, J. L., Li, M., Chen, I. C., Lo, Y. S., Wu, H. C. & Chen, C. M., 2016 3月 1, 於: Parkinsonism and Related Disorders. 24, p. 81-88 8 p.

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29 引文斯高帕斯（Scopus）

Medicinal herbs Oenanthe javanica (Blume) DC., Casuarina equisetifolia L. and Sorghum bicolor (L.) Moench protect human cells from MPP⁺ damage via inducing FBXO7 expression

Chen, C. M., Chen, I. C., Chen, Y. L., Lin, T. H., Chen, W. L., Chao, C. Y., Wu, Y. R., Lu, Y. T., Lee, C. Y., Chien, H. C., Chen, T. S., Lee-Chen, G. J. & Lee, C. M., 2016 11月 15, 於: Phytomedicine. 23, 12, p. 1422-1433 12 p.

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5 引文斯高帕斯（Scopus）

Novel lactulose and melibiose targeting autophagy to reduce polyQ aggregation in cell models of spinocerebellar ataxia

Lin, C. H., Wu, Y. R., Yang, J. M., Chen, W. L., Chao, C. Y., Chen, I. C., Lin, T. H., Wu, Y. C., Hsu, K. C., Chen, C. M., Lee, G. C., Hsieh-Li, H. M., Lee, C. M. & Lee-Chen, G. J., 2016 4月 1, 於: CNS and Neurological Disorders - Drug Targets. 15, 3, p. 351-359 9 p.

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15 引文斯高帕斯（Scopus）

Targeting the prodromal stage of spinocerebellar ataxia type 17 mice: G-CSF in the prevention of motor deficits via upregulating chaperone and autophagy levels

Chang, Y. C., Lin, C. W., Hsu, C. M., Lee-Chen, G. J., Su, M. T., Ro, L. S., Chen, C. M., Huang, H. J. & Hsieh-Li, H. M., 2016, 於: Brain Research. 1639, p. 132-148 17 p.

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12 引文斯高帕斯（Scopus）

The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer’s disease

Chang, K. H., Chen, I. C., Lin, H. Y., Chen, H. C., Lin, C. H., Lin, T. H., Weng, Y. T., Chao, C. Y., Wu, Y. R., Lin, J. Y., Lee-Chen, G. J. & Chen, C. M., 2016 2月 29, 於: Drug Design, Development and Therapy. 10, p. 885-896 12 p.

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22 引文斯高帕斯（Scopus）

The potential of synthetic indolylquinoline derivatives for Aβ aggregation reduction by chemical chaperone activity

Chang, K. H., Chiu, Y. J., Chen, S. L., Huang, C. H., Lin, C. H., Lin, T. H., Lee, C. M., Ramesh, C., Wu, C. H., Huang, C. C., Fung, H. C., Chen, Y. C., Lin, J. Y., Yao, C. F., Huang, H. J., Lee-Chen, G. J., Lee, M. C. & Hsieh-Li, H. M., 2016 2月 1, 於: Neuropharmacology. 101, p. 309-319 11 p.

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17 引文斯高帕斯（Scopus）

Treatment with a Ginkgo biloba extract, EGb 761, inhibits excitotoxicity in an animal model of spinocerebellar ataxia type 17

Huang, D. S., Lin, H. Y., Lee-Chen, G. J., Hsieh-Li, H. M., Wu, C. H. & Lin, J. Y., 2016 2月 18, 於: Drug Design, Development and Therapy. 10, p. 723-731 9 p.

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12 引文斯高帕斯（Scopus）

2015

Protein kinase Cη polymorphism and the susceptibility to ischemic stroke in the Taiwan population

Chen, Y. C., Huang, C. J., Chen, P., Wu, Y. R., Shie, S. S., Chen, S. T., Lee-Chen, G. J. & Chen, C. M., 2015 9月 1, 於: Biomedical Journal. 38, 5, p. 433-438 6 p.

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3 引文斯高帕斯（Scopus）

李 桂楨

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李桂楨