• 1592 引文
  • 20 h-指數
19992020

每年研究成果

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研究成果

  • 1592 引文
  • 20 h-指數
  • 45 文章
  • 3 综述文章
篩選
文章
2020

Targeting Inflammation, PHA-767491 Shows a Broad Spectrum in Protein Aggregation Diseases

Chung, Y. H., Lin, C. W., Huang, H. Y., Chen, S. L., Huang, H. J., Sun, Y. C., Lee, G. C., Lee-Chen, G. J., Chang, Y. C. & Hsieh-Li, H. M., 2020 一月 1, (接受/付印) 於 : Journal of Molecular Neuroscience. 70, 7, p. 1140-1152 13 p.

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)
2019

Chronic low dose of AM404 ameliorates the cognitive impairment and pathological features in hyperglycemic 3xTg-AD mice

Huang, H. J., Chen, S. L., Huang, H. Y., Sun, Y. C., Lee, G. C., Lee-Chen, G. J., Hsieh-Li, H. M. & Su, M. T., 2019 二月 14, 於 : Psychopharmacology. 236, 2, p. 763-773 11 p.

研究成果: 雜誌貢獻文章

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5 引文 斯高帕斯(Scopus)
2 引文 斯高帕斯(Scopus)
2018

Genetic and functional characters of GRN p.T487I mutation in Taiwanese patients with atypical parkinsonian disorders

Chang, K. H., Lee, G. C., Huang, C. C., Kuo, H. C., Chen, C. M., Hsiao, Y. C., Hsu, H. C., Hsu, K. J., Lin, C. H., Chang, C. W., Lee-Chen, G. J. & Wu, Y. R., 2018 六月, 於 : Parkinsonism and Related Disorders. 51, p. 61-66 6 p.

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)
2017

Investigation of the bindings of a class of inhibitors with GSK3β kinase using thermodynamic integration MD simulation and kinase assay

Hsu, C. J., Hsu, W. C., Lee, D. J., Liu, A. L., Chang, C. M., Shih, H. J., Huang, W. H., Lee-Chen, G. J., Hsieh-Li, H. M., Lee, G. C. & Sun, Y. C., 2017 八月 1, 於 : Chemical Biology and Drug Design. 90, 2, p. 272-281 10 p.

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)

The N253F mutant structure of trehalose synthase from Deinococcus radiodurans reveals an open active-site topology

Chow, S. Y., Wang, Y. L., Hsieh, Y. C., Lee, G. C. & Liaw, S. H., 2017 十一月, 於 : Acta Crystallographica Section F:Structural Biology Communications. 73, 11, p. 588-594 7 p.

研究成果: 雜誌貢獻文章

2016

Constitutive expression of recombinant human hyaluronidase PH20 by Pichia pastoris

Chen, K. J., Sabrina, S., El-Safory, N. S., Lee, G. C. & Lee, C. K., 2016 十二月 1, 於 : Journal of Bioscience and Bioengineering. 122, 6, p. 673-678 6 p.

研究成果: 雜誌貢獻文章

4 引文 斯高帕斯(Scopus)

Identifying GSK-3β kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays

Lin, C. H., Hsieh, Y. S., Wu, Y. R., Hsu, C. J., Chen, H. C., Huang, W. H., Chang, K. H., Hsieh-Li, H. M., Su, M. T., Sun, Y. C., Lee, G. C. & Lee-Chen, G. J., 2016 六月 30, 於 : European Journal of Pharmaceutical Sciences. 89, p. 11-19 9 p.

研究成果: 雜誌貢獻文章

14 引文 斯高帕斯(Scopus)

Novel lactulose and melibiose targeting autophagy to reduce polyQ aggregation in cell models of spinocerebellar ataxia

Lin, C. H., Wu, Y. R., Yang, J. M., Chen, W. L., Chao, C. Y., Chen, I. C., Lin, T. H., Wu, Y. C., Hsu, K. C., Chen, C. M., Lee, G. C., Hsieh-Li, H. M., Lee, C. M. & Lee-Chen, G. J., 2016 四月 1, 於 : CNS and Neurological Disorders - Drug Targets. 15, 3, p. 351-359 9 p.

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)
2015

Conversion of crude Jatropha curcas seed oil into biodiesel using liquid recombinant Candida rugosa lipase isozymes

Kuo, T. C., Shaw, J. F. & Lee, G-C., 2015 九月 1, 於 : Bioresource Technology. 192, p. 54-59 6 p.

研究成果: 雜誌貢獻文章

32 引文 斯高帕斯(Scopus)

Improvement in the secretory expression of recombinant Candida rugosa lipase in Pichia pastoris

Kuo, T. C., Shaw, J. F. & Lee, G. C., 2015 十二月 1, 於 : Process Biochemistry. 50, 12, p. 2137-2143 7 p.

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)

The potential of lactulose and melibiose, two novel trehalase-indigestible and autophagy-inducing disaccharides, for polyQ-mediated neurodegenerative disease treatment

Lee, G. C., Lin, C. H., Tao, Y. C., Yang, J. M., Hsu, K. C., Huang, Y. J., Huang, S. H., Kung, P. J., Chen, W. L., Wang, C. M., Wu, Y. R., Chen, C. M., Lin, J. Y., Hsieh-Li, H. M. & Lee-Chen, G. J., 2015 五月 1, 於 : NeuroToxicology. 48, p. 120-130 11 p.

研究成果: 雜誌貢獻文章

9 引文 斯高帕斯(Scopus)

Trehalose Attenuates the Gait Ataxia and Gliosis of Spinocerebellar Ataxia Type 17 Mice

Chen, Z. Z., Wang, C. M., Lee, G. C., Hsu, H. C., Wu, T. L., Lin, C. W., Ma, C. K., Lee-Chen, G. J., Huang, H. J. & Hsieh-Li, H. M., 2015 一月 1, 於 : Neurochemical Research. 40, 4, p. 800-810 11 p.

研究成果: 雜誌貢獻文章

19 引文 斯高帕斯(Scopus)
2014

Structures of trehalose synthase from Deinococcus radiodurans reveal that a closed conformation is involved in catalysis of the intramolecular isomerization

Wang, Y. L., Chow, S. Y., Lin, Y. T., Hsieh, Y. C., Lee, G. C. & Liaw, S. H., 2014 十二月 1, 於 : Acta Crystallographica Section D: Biological Crystallography. 70, 12, p. 3144-3154 11 p.

研究成果: 雜誌貢獻文章

10 引文 斯高帕斯(Scopus)
2013

Interaction Analysis Between Polyglutamine-expanded TATA Box Binding Protein (TBP) and High Mobility Group Box 1 (HMGB1)

楊淑婷(Shu-Ting Y, 陳襄銘(Hsiang-Ming C, 李麗卿(Li-Ching L, 黃詩涵(Shih-Han H, 林志信(Chih-Hsin L, 李冠群(Guan-Chiun L, 李振綱(Cheng-Kang L & 李桂楨(Guey-Jen L-C, 2013, 於 : Bio Formosa. 48, p. 17-26 10 p.

研究成果: 雜誌貢獻文章

2012

Role of the CCAAT-binding protein NFY in SCA17 pathogenesis

Lee, L. C., Chen, C. M., Wang, H. C., Hsieh, H. H., Chiu, I. S., Su, M. T., Hsieh-Li, H. M., Wu, C. H., Lee, G. C., Lee-Chen, G. J. & Lin, J. Y., 2012 四月 17, 於 : PloS one. 7, 4, e35302.

研究成果: 雜誌貢獻文章

22 引文 斯高帕斯(Scopus)

建立高重組蛋白表達之酵母菌Pichia Pastoris系統

郭亭君(Ting-Chun K, 張瀞文(Jing-Wen C, 李振綱 & 李冠群(Guan-Chun L, 2012, 於 : Bio Formosa. 47, p. 43-49 7 p.

研究成果: 雜誌貢獻文章

2011

Characterization of codon-optimized recombinant Candida rugosa Lipase 5 (LIP5)

Lee, L. C., Yen, C. C., Malmis, C. C., Chen, L. F., Chen, J. C., Lee, G-C. & Shaw, J. F., 2011 十月 12, 於 : Journal of Agricultural and Food Chemistry. 59, 19, p. 10693-10698 6 p.

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)

Characterization of hyaluronate lyase from Streptococcus pyogenes bacteriophage H4489A

El-Safory, N. S., Lee, G. C. & Lee, C. K., 2011 三月 17, 於 : Carbohydrate Polymers. 84, 3, p. 1182-1191 10 p.

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)
11 引文 斯高帕斯(Scopus)
2010

Genes and biochemical characterization of three novel chlorophyllase isozymes from Brassica oleracea

Lee, G. C., Chepyshko, H., Chen, H. H., Chu, C. C., Chou, Y. F., Akoh, C. C. & Shaw, J. F., 2010 八月 11, 於 : Journal of Agricultural and Food Chemistry. 58, 15, p. 8651-8657 7 p.

研究成果: 雜誌貢獻文章

16 引文 斯高帕斯(Scopus)

Site-directed mutagenesis improves the thermostability of a recombinant Picrophilus torridus trehalose synthase and efficiency for the production of trehalose from sweet potato starch

Chou, H. H., Chang, S. W., Lee, G. C., Chen, Y. S., Yeh, T., Akoh, C. C. & Shaw, J. F., 2010 四月 1, 於 : Food Chemistry. 119, 3, p. 1017-1022 6 p.

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)
15 引文 斯高帕斯(Scopus)
2009

Altered expression of HSPA5, HSPA8 and PARK7 in spinocerebellar ataxia type 17 identified by 2-dimensional fluorescence difference in gel electrophoresis

Lee, L. C., Chen, C. M., Chen, F. L., Lin, P. Y., Hsiao, Y. C., Wang, P. R., Su, M. T., Hsieh-Li, H. M., Hwang, J. C., Wu, C. H., Lee, G. C., Singh, S., Lin, Y., Hsieh, S. Y., Lee-Chen, G. J. & Lin, J. Y., 2009 二月 1, 於 : Clinica Chimica Acta. 400, 1-2, p. 56-62 7 p.

研究成果: 雜誌貢獻文章

18 引文 斯高帕斯(Scopus)

Structure of the Alkalohyperthermophilic Archaeoglobus fulgidus Lipase Contains a Unique C-Terminal Domain Essential for Long-Chain Substrate Binding

Chen, C. K. M., Lee, G. C., Ko, T. P., Guo, R. T., Huang, L. M., Liu, H. J., Ho, Y. F., Shaw, J. F. & Wang, A. H. J., 2009 七月 24, 於 : Journal of Molecular Biology. 390, 4, p. 672-685 14 p.

研究成果: 雜誌貢獻文章

20 引文 斯高帕斯(Scopus)
2008
16 引文 斯高帕斯(Scopus)
2007

Altering the substrate specificity of Candida rugosa LIP4 by engineering the substrate-binding sites

Lee, L. C., Chen, Y. T., Yen, C. C., Chiang, T. C. Y., Tang, S. J., Lee, G-C. & Shaw, J. F., 2007 六月 27, 於 : Journal of Agricultural and Food Chemistry. 55, 13, p. 5103-5108 6 p.

研究成果: 雜誌貢獻文章

18 引文 斯高帕斯(Scopus)
29 引文 斯高帕斯(Scopus)

Enzymatic approach to biodiesel production

Akoh, C. C., Chang, S. W., Lee, G. C. & Shaw, J. F., 2007 十月 31, 於 : Journal of Agricultural and Food Chemistry. 55, 22, p. 8995-9005 11 p.

研究成果: 雜誌貢獻文章

256 引文 斯高帕斯(Scopus)

Gene cloning and characterization of a novel recombinant antifungal chitinase from papaya (carica papaya)

Chen, Y. T., Hsu, L. H., Huang, I. P., Tsai, T. C., Lee, G. C. & Shaw, J. F., 2007 二月 7, 於 : Journal of Agricultural and Food Chemistry. 55, 3, p. 714-722 9 p.

研究成果: 雜誌貢獻文章

25 引文 斯高帕斯(Scopus)

Role of the C-terminal domain of Thermus thermophilus trehalose synthase in the thermophilicity, thermostability, and efficient production of trehalose

Wang, J. H., Tsai, M. Y., Chen, J. J., Lee, G. C. & Shaw, J. F., 2007 五月 2, 於 : Journal of Agricultural and Food Chemistry. 55, 9, p. 3435-3443 9 p.

研究成果: 雜誌貢獻文章

26 引文 斯高帕斯(Scopus)

Synthesis and characterization of canola oil-stearic acid-based trans-free structured lipids for possible margarine application

Lumor, S. E., Jones, K. C., Ashby, R., Strahan, G. D., Byung, H. K., Lee, G-C., Shaw, J. F., Kays, S. E., Chang, S. W., Foglia, T. A. & Akoh, C. C., 2007 十二月 26, 於 : Journal of Agricultural and Food Chemistry. 55, 26, p. 10692-10702 11 p.

研究成果: 雜誌貢獻文章

22 引文 斯高帕斯(Scopus)
2006

Candida rugosa lipase LIP1-catalyzed transesterification to produce human milk fat substitute

Srivastava, A., Akoh, C. C., Chang, S. W., Lee, G. C. & Shaw, J. F., 2006 七月 12, 於 : Journal of Agricultural and Food Chemistry. 54, 14, p. 5175-5181 7 p.

研究成果: 雜誌貢獻文章

44 引文 斯高帕斯(Scopus)
69 引文 斯高帕斯(Scopus)
30 引文 斯高帕斯(Scopus)
56 引文 斯高帕斯(Scopus)

Optimized growth kinetics of Pichia pastoris and recombinant Candida rugosa LIP1 production by RSM

Chang, S. W., Shieh, C. J., Lee, G-C., Akoh, C. C. & Shaw, J. F., 2006 七月 1, 於 : Journal of Molecular Microbiology and Biotechnology. 11, 1-2, p. 28-40 13 p.

研究成果: 雜誌貢獻文章

8 引文 斯高帕斯(Scopus)
2005

Multiple mutagenesis of the Candida rugosa LIP1 gene and optimum production of recombinant LIP1 expressed in Pichia pastoris

Chang, S. W., Shieh, C. J., Lee, G-C. & Shaw, J. F., 2005 四月 1, 於 : Applied Microbiology and Biotechnology. 67, 2, p. 215-224 10 p.

研究成果: 雜誌貢獻文章

22 引文 斯高帕斯(Scopus)
2004

Lipase-catalyzed alcoholysis of triglycerides for short-chain monoglyceride production

Lee, G. C., Wang, D. L., Ho, Y. F. & Shaw, J. F., 2004 六月, 於 : JAOCS, Journal of the American Oil Chemists' Society. 81, 6, p. 533-536 4 p.

研究成果: 雜誌貢獻文章

18 引文 斯高帕斯(Scopus)
2003

A transformation system for the nonuniversal CUGSer codon usage species Candida rugosa

Tang, S. J., Sun, K. H., Sun, G. H., Chang, T. Y., Wu, W. L. & Lee, G. C., 2003 二月 1, 於 : Journal of Microbiological Methods. 52, 2, p. 231-238 8 p.

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)
2002

Factors affecting the resolution of dl-menthol by immobilized lipase-catalyzed esterification in organic solvent

Wang, D. L., Nag, A., Lee, G-C. & Shaw, J. F., 2002 一月 16, 於 : Journal of Agricultural and Food Chemistry. 50, 2, p. 262-265 4 p.

研究成果: 雜誌貢獻文章

39 引文 斯高帕斯(Scopus)
41 引文 斯高帕斯(Scopus)
2001

Recombinant expression and characterization of the Candida rugosa lip4 lipase in Pichia pastoris: Comparison of glycosylation, activity, and stability

Tang, S. J., Shaw, J. F., Sun, K. H., Sun, G. H., Chang, T. Y., Lin, C. K., Lo, Y. C. & Lee, G. C., 2001 三月 1, 於 : Archives of Biochemistry and Biophysics. 387, 1, p. 93-98 6 p.

研究成果: 雜誌貢獻文章

59 引文 斯高帕斯(Scopus)
2000

Recombinant expression of the Candida rugosa lip4 lipase in Escherichia coli

Tang, S. J., Sun, K. H., Sun, G. H., Chang, T. Y. & Lee, G-C., 2000 一月 1, 於 : Protein Expression and Purification. 20, 2, p. 308-313 6 p.

研究成果: 雜誌貢獻文章

23 引文 斯高帕斯(Scopus)
1999

Analysis of the gene family encoding lipases in Candida rugosa by competitive reverse transcription-PCR

Lee, G. C., Tang, S. J., Sun, K. H. & Shaw, J. F., 1999 九月, 於 : Applied and Environmental Microbiology. 65, 9, p. 3888-3895 8 p.

研究成果: 雜誌貢獻文章

開啟存取
36 引文 斯高帕斯(Scopus)