Zirconium-Based Metal-Organic Framework Nanocarrier for the Controlled Release of Ibuprofen

Hung Li Wang; Hsin Yeh; Bin Han Li; Chia Her Lin; Ta Chih Hsiao; De Hao Tsai

doi:10.1021/acsanm.9b00834

Zirconium-Based Metal-Organic Framework Nanocarrier for the Controlled Release of Ibuprofen

Hung Li Wang, Hsin Yeh, Bin Han Li, Chia Her Lin, Ta Chih Hsiao^*, De Hao Tsai

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Electrospray-differential mobility analysis coupled with aerosol particle mass analysis (ES-DMA/APM) was demonstrated for the development of a metal-organic framework (MOF) nanocarrier system. A successful quantification of ibuprofen loading in UiO-66-NH₂ (i.e., the representative drug molecule and MOF, respectively) achieved based on the aerosol particle mass of MOF measured by ES-DMA/APM (≈55 mg of ibuprofen/g of UiO-66-NH₂). The structural stability of UiO-66-NH₂ versus ibuprofen release was successfully quantified over a 7-day period in an acidic phosphate buffer solution. The methodology provides a proof-of-concept scheme for controlled release studies of different types of active pharmaceutical ingredients from a variety of MOF-based nanocarrier systems.

Original language	English
Pages (from-to)	3329-3334
Number of pages	6
Journal	ACS Applied Nano Materials
Volume	2
Issue number	6
DOIs	https://doi.org/10.1021/acsanm.9b00834
Publication status	Published - 2019 Jun 28
Externally published	Yes

Keywords

aerosol
colloid
drug
metal-organic framework
release

ASJC Scopus subject areas

General Materials Science

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10.1021/acsanm.9b00834

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title = "Zirconium-Based Metal-Organic Framework Nanocarrier for the Controlled Release of Ibuprofen",

abstract = "Electrospray-differential mobility analysis coupled with aerosol particle mass analysis (ES-DMA/APM) was demonstrated for the development of a metal-organic framework (MOF) nanocarrier system. A successful quantification of ibuprofen loading in UiO-66-NH2 (i.e., the representative drug molecule and MOF, respectively) achieved based on the aerosol particle mass of MOF measured by ES-DMA/APM (≈55 mg of ibuprofen/g of UiO-66-NH2). The structural stability of UiO-66-NH2 versus ibuprofen release was successfully quantified over a 7-day period in an acidic phosphate buffer solution. The methodology provides a proof-of-concept scheme for controlled release studies of different types of active pharmaceutical ingredients from a variety of MOF-based nanocarrier systems.",

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author = "Wang, {Hung Li} and Hsin Yeh and Li, {Bin Han} and Lin, {Chia Her} and Hsiao, {Ta Chih} and Tsai, {De Hao}",

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doi = "10.1021/acsanm.9b00834",

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AU - Wang, Hung Li

AU - Yeh, Hsin

AU - Li, Bin Han

AU - Lin, Chia Her

AU - Hsiao, Ta Chih

AU - Tsai, De Hao

PY - 2019/6/28

Y1 - 2019/6/28

N2 - Electrospray-differential mobility analysis coupled with aerosol particle mass analysis (ES-DMA/APM) was demonstrated for the development of a metal-organic framework (MOF) nanocarrier system. A successful quantification of ibuprofen loading in UiO-66-NH2 (i.e., the representative drug molecule and MOF, respectively) achieved based on the aerosol particle mass of MOF measured by ES-DMA/APM (≈55 mg of ibuprofen/g of UiO-66-NH2). The structural stability of UiO-66-NH2 versus ibuprofen release was successfully quantified over a 7-day period in an acidic phosphate buffer solution. The methodology provides a proof-of-concept scheme for controlled release studies of different types of active pharmaceutical ingredients from a variety of MOF-based nanocarrier systems.

AB - Electrospray-differential mobility analysis coupled with aerosol particle mass analysis (ES-DMA/APM) was demonstrated for the development of a metal-organic framework (MOF) nanocarrier system. A successful quantification of ibuprofen loading in UiO-66-NH2 (i.e., the representative drug molecule and MOF, respectively) achieved based on the aerosol particle mass of MOF measured by ES-DMA/APM (≈55 mg of ibuprofen/g of UiO-66-NH2). The structural stability of UiO-66-NH2 versus ibuprofen release was successfully quantified over a 7-day period in an acidic phosphate buffer solution. The methodology provides a proof-of-concept scheme for controlled release studies of different types of active pharmaceutical ingredients from a variety of MOF-based nanocarrier systems.

KW - aerosol

KW - colloid

KW - drug

KW - metal-organic framework

KW - release

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Zirconium-Based Metal-Organic Framework Nanocarrier for the Controlled Release of Ibuprofen

Abstract

Keywords

ASJC Scopus subject areas

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