Zirconium-Based Metal-Organic Framework Nanocarrier for the Controlled Release of Ibuprofen

Hung Li Wang, Hsin Yeh, Bin Han Li, Chia Her Lin, Ta Chih Hsiao*, De Hao Tsai

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Electrospray-differential mobility analysis coupled with aerosol particle mass analysis (ES-DMA/APM) was demonstrated for the development of a metal-organic framework (MOF) nanocarrier system. A successful quantification of ibuprofen loading in UiO-66-NH2 (i.e., the representative drug molecule and MOF, respectively) achieved based on the aerosol particle mass of MOF measured by ES-DMA/APM (≈55 mg of ibuprofen/g of UiO-66-NH2). The structural stability of UiO-66-NH2 versus ibuprofen release was successfully quantified over a 7-day period in an acidic phosphate buffer solution. The methodology provides a proof-of-concept scheme for controlled release studies of different types of active pharmaceutical ingredients from a variety of MOF-based nanocarrier systems.

Original languageEnglish
Pages (from-to)3329-3334
Number of pages6
JournalACS Applied Nano Materials
Volume2
Issue number6
DOIs
Publication statusPublished - 2019 Jun 28
Externally publishedYes

Keywords

  • aerosol
  • colloid
  • drug
  • metal-organic framework
  • release

ASJC Scopus subject areas

  • Materials Science(all)

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