Zerumbet Ginger Extract Attenuates Chemotherapy-Induced Toxicity and Promotes Tumor Suppression in a Murine Breast Cancer Model

Li Yu Su; Liang Chuan Lai; Chi Feng Cheng; Chia Ying Lien; Ming Chung Lee; Wu Chang Chuang; Chung Hsin Wu

doi:10.1002/fsn3.71273

Zerumbet Ginger Extract Attenuates Chemotherapy-Induced Toxicity and Promotes Tumor Suppression in a Murine Breast Cancer Model

Li Yu Su
, Liang Chuan Lai^*
, Chi Feng Cheng
, Chia Ying Lien
, Ming Chung Lee
, Wu Chang Chuang
, Chung Hsin Wu^*

^*Corresponding author for this work

Department of Life Science

Research output: Contribution to journal › Article › peer-review

Abstract

Zerumbet ginger extract (ZGE) shows strong anticancer potential and enhances doxorubicin (DOX) efficacy against breast cancer while reducing its systemic toxicity. GC–MS identified zerumbone as a key bioactive. ZGE inhibited 4 T1 cell growth and tumor progression in mice and improved antioxidant activity. Combined ZGE + DOX treatment boosted antitumor effects and alleviated DOX-induced cardiotoxicity, hepatotoxicity, and nephrotoxicity, as reflected in biochemical markers. Mechanistically, ZGE suppressed TRPM2 and calcium signaling, promoting ROS-mediated apoptosis. These findings support ZGE as a promising adjuvant in breast cancer therapy.

Original language	English
Article number	e71273
Journal	Food Science and Nutrition
Volume	13
Issue number	12
DOIs	https://doi.org/10.1002/fsn3.71273
Publication status	Published - 2025 Dec

Keywords

TRPM2 channel
antioxidant activity
breast cancer
chemotherapy
doxorubicin
zerumbet ginger extract

ASJC Scopus subject areas

Food Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/fsn3.71273

Cite this

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title = "Zerumbet Ginger Extract Attenuates Chemotherapy-Induced Toxicity and Promotes Tumor Suppression in a Murine Breast Cancer Model",

abstract = "Zerumbet ginger extract (ZGE) shows strong anticancer potential and enhances doxorubicin (DOX) efficacy against breast cancer while reducing its systemic toxicity. GC–MS identified zerumbone as a key bioactive. ZGE inhibited 4 T1 cell growth and tumor progression in mice and improved antioxidant activity. Combined ZGE + DOX treatment boosted antitumor effects and alleviated DOX-induced cardiotoxicity, hepatotoxicity, and nephrotoxicity, as reflected in biochemical markers. Mechanistically, ZGE suppressed TRPM2 and calcium signaling, promoting ROS-mediated apoptosis. These findings support ZGE as a promising adjuvant in breast cancer therapy.",

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author = "Su, \{Li Yu\} and Lai, \{Liang Chuan\} and Cheng, \{Chi Feng\} and Lien, \{Chia Ying\} and Lee, \{Ming Chung\} and Chuang, \{Wu Chang\} and Wu, \{Chung Hsin\}",

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year = "2025",

month = dec,

doi = "10.1002/fsn3.71273",

language = "English",

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journal = "Food Science and Nutrition",

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T1 - Zerumbet Ginger Extract Attenuates Chemotherapy-Induced Toxicity and Promotes Tumor Suppression in a Murine Breast Cancer Model

AU - Su, Li Yu

AU - Lai, Liang Chuan

AU - Cheng, Chi Feng

AU - Lien, Chia Ying

AU - Lee, Ming Chung

AU - Chuang, Wu Chang

AU - Wu, Chung Hsin

PY - 2025/12

Y1 - 2025/12

N2 - Zerumbet ginger extract (ZGE) shows strong anticancer potential and enhances doxorubicin (DOX) efficacy against breast cancer while reducing its systemic toxicity. GC–MS identified zerumbone as a key bioactive. ZGE inhibited 4 T1 cell growth and tumor progression in mice and improved antioxidant activity. Combined ZGE + DOX treatment boosted antitumor effects and alleviated DOX-induced cardiotoxicity, hepatotoxicity, and nephrotoxicity, as reflected in biochemical markers. Mechanistically, ZGE suppressed TRPM2 and calcium signaling, promoting ROS-mediated apoptosis. These findings support ZGE as a promising adjuvant in breast cancer therapy.

AB - Zerumbet ginger extract (ZGE) shows strong anticancer potential and enhances doxorubicin (DOX) efficacy against breast cancer while reducing its systemic toxicity. GC–MS identified zerumbone as a key bioactive. ZGE inhibited 4 T1 cell growth and tumor progression in mice and improved antioxidant activity. Combined ZGE + DOX treatment boosted antitumor effects and alleviated DOX-induced cardiotoxicity, hepatotoxicity, and nephrotoxicity, as reflected in biochemical markers. Mechanistically, ZGE suppressed TRPM2 and calcium signaling, promoting ROS-mediated apoptosis. These findings support ZGE as a promising adjuvant in breast cancer therapy.

KW - TRPM2 channel

KW - antioxidant activity

KW - breast cancer

KW - chemotherapy

KW - doxorubicin

KW - zerumbet ginger extract

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UR - https://www.scopus.com/pages/publications/105022852288#tab=citedBy

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DO - 10.1002/fsn3.71273

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JO - Food Science and Nutrition

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ER -

Zerumbet Ginger Extract Attenuates Chemotherapy-Induced Toxicity and Promotes Tumor Suppression in a Murine Breast Cancer Model

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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