Wash-free immunomagnetic detection for serum through magnetic susceptibility reduction

Chin Yih Hong; W. S. Chen; Z. F. Jian; S. Y. Yang; H. E. Horng; L. C. Yang; H. C. Yang

doi:10.1063/1.2536127

Wash-free immunomagnetic detection for serum through magnetic susceptibility reduction

Chin Yih Hong
, W. S. Chen
, Z. F. Jian
, S. Y. Yang
, H. E. Horng^*
, L. C. Yang
, H. C. Yang

^*Corresponding author for this work

Undergraduate Program of Electro-Optical Engineering

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

In this study, a platform for wash-free immunomagnetic detections is discussed. The reagent is a magnetic fluid composed of biofunctionalized magnetic particles dispersed in water. The assay instrument is a mixed-frequency magnetosusceptometer. The mixed-frequency ac magnetic susceptibility ac of the magnetic reagent is reduced, as a result of the formation of magnetic clusters via the association among magnetic nanoparticles and a specific biotarget. The immunoassay detection of proteins in water, such as aqueous c-reactive protein, is characterized and is compared to that in serum. These observations demonstrate the advantages of high convenience, high sensitivity, and high specificity for ac -reduction immunomagnetic detection.

Original language	English
Article number	074105
Journal	Applied Physics Letters
Volume	90
Issue number	7
DOIs	https://doi.org/10.1063/1.2536127
Publication status	Published - 2007

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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10.1063/1.2536127

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title = "Wash-free immunomagnetic detection for serum through magnetic susceptibility reduction",

abstract = "In this study, a platform for wash-free immunomagnetic detections is discussed. The reagent is a magnetic fluid composed of biofunctionalized magnetic particles dispersed in water. The assay instrument is a mixed-frequency magnetosusceptometer. The mixed-frequency ac magnetic susceptibility ac of the magnetic reagent is reduced, as a result of the formation of magnetic clusters via the association among magnetic nanoparticles and a specific biotarget. The immunoassay detection of proteins in water, such as aqueous c-reactive protein, is characterized and is compared to that in serum. These observations demonstrate the advantages of high convenience, high sensitivity, and high specificity for ac -reduction immunomagnetic detection.",

author = "Hong, \{Chin Yih\} and Chen, \{W. S.\} and Jian, \{Z. F.\} and Yang, \{S. Y.\} and Horng, \{H. E.\} and Yang, \{L. C.\} and Yang, \{H. C.\}",

year = "2007",

doi = "10.1063/1.2536127",

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volume = "90",

journal = "Applied Physics Letters",

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T1 - Wash-free immunomagnetic detection for serum through magnetic susceptibility reduction

AU - Hong, Chin Yih

AU - Chen, W. S.

AU - Jian, Z. F.

AU - Yang, S. Y.

AU - Horng, H. E.

AU - Yang, L. C.

AU - Yang, H. C.

PY - 2007

Y1 - 2007

N2 - In this study, a platform for wash-free immunomagnetic detections is discussed. The reagent is a magnetic fluid composed of biofunctionalized magnetic particles dispersed in water. The assay instrument is a mixed-frequency magnetosusceptometer. The mixed-frequency ac magnetic susceptibility ac of the magnetic reagent is reduced, as a result of the formation of magnetic clusters via the association among magnetic nanoparticles and a specific biotarget. The immunoassay detection of proteins in water, such as aqueous c-reactive protein, is characterized and is compared to that in serum. These observations demonstrate the advantages of high convenience, high sensitivity, and high specificity for ac -reduction immunomagnetic detection.

AB - In this study, a platform for wash-free immunomagnetic detections is discussed. The reagent is a magnetic fluid composed of biofunctionalized magnetic particles dispersed in water. The assay instrument is a mixed-frequency magnetosusceptometer. The mixed-frequency ac magnetic susceptibility ac of the magnetic reagent is reduced, as a result of the formation of magnetic clusters via the association among magnetic nanoparticles and a specific biotarget. The immunoassay detection of proteins in water, such as aqueous c-reactive protein, is characterized and is compared to that in serum. These observations demonstrate the advantages of high convenience, high sensitivity, and high specificity for ac -reduction immunomagnetic detection.

UR - https://www.scopus.com/pages/publications/33847158802

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M3 - Article

AN - SCOPUS:33847158802

SN - 0003-6951

VL - 90

JO - Applied Physics Letters

JF - Applied Physics Letters

IS - 7

M1 - 074105

ER -

Wash-free immunomagnetic detection for serum through magnetic susceptibility reduction

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