Wash-free immunomagnetic detection for serum through magnetic susceptibility reduction

Chin Yih Hong, W. S. Chen, Z. F. Jian, S. Y. Yang, H. E. Horng*, L. C. Yang, H. C. Yang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

In this study, a platform for wash-free immunomagnetic detections is discussed. The reagent is a magnetic fluid composed of biofunctionalized magnetic particles dispersed in water. The assay instrument is a mixed-frequency magnetosusceptometer. The mixed-frequency ac magnetic susceptibility ac of the magnetic reagent is reduced, as a result of the formation of magnetic clusters via the association among magnetic nanoparticles and a specific biotarget. The immunoassay detection of proteins in water, such as aqueous c-reactive protein, is characterized and is compared to that in serum. These observations demonstrate the advantages of high convenience, high sensitivity, and high specificity for ac -reduction immunomagnetic detection.

Original languageEnglish
Article number074105
JournalApplied Physics Letters
Volume90
Issue number7
DOIs
Publication statusPublished - 2007
Externally publishedYes

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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