Wash-free immunomagnetic detection for serum through magnetic susceptibility reduction

Chin Yih Hong, W. S. Chen, Z. F. Jian, S. Y. Yang, H. E. Horng, L. C. Yang, H. C. Yang

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    Abstract

    In this study, a platform for wash-free immunomagnetic detections is discussed. The reagent is a magnetic fluid composed of biofunctionalized magnetic particles dispersed in water. The assay instrument is a mixed-frequency magnetosusceptometer. The mixed-frequency ac magnetic susceptibility ac of the magnetic reagent is reduced, as a result of the formation of magnetic clusters via the association among magnetic nanoparticles and a specific biotarget. The immunoassay detection of proteins in water, such as aqueous c-reactive protein, is characterized and is compared to that in serum. These observations demonstrate the advantages of high convenience, high sensitivity, and high specificity for ac -reduction immunomagnetic detection.

    Original languageEnglish
    Article number074105
    JournalApplied Physics Letters
    Volume90
    Issue number7
    DOIs
    Publication statusPublished - 2007

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    ASJC Scopus subject areas

    • Physics and Astronomy (miscellaneous)

    Cite this

    Hong, C. Y., Chen, W. S., Jian, Z. F., Yang, S. Y., Horng, H. E., Yang, L. C., & Yang, H. C. (2007). Wash-free immunomagnetic detection for serum through magnetic susceptibility reduction. Applied Physics Letters, 90(7), [074105]. https://doi.org/10.1063/1.2536127