Vescalagin from pink wax apple [Syzygium samarangense (Blume) Merrill and Perry] alleviates hepatic insulin resistance and ameliorates glycemic metabolism abnormality in rats fed a high-fructose diet

Da Wei Huang, Wen Chang Chang, James Swi Bea Wu, Rui Wen Shih, Szu Chuan Shen*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)

    Abstract

    This study investigates the ameliorative effect of vescalagin (VES) isolated from Pink wax apple fruit on hepatic insulin resistance and abnormal carbohydrate metabolism in high-fructose diet (HFD)-induced hyperglycemic rats. The results show that in HFD rats, VES significantly reduced the values of the area under the curve for glucose in an oral glucose tolerance test and the homeostasis model assessment of insulin resistance index. VES significantly enhanced the activity of hepatic antioxidant enzymes while reducing thiobarbituric acid-reactive substances in HFD rats. Western blot assay revealed that VES reduced hepatic protein expression involved in inflammation pathways while up-regulating expression of hepatic insulin signaling-related proteins. Moreover, VES up-regulated the expression of hepatic glycogen synthase and hepatic glycolysis-related proteins while down-regulating hepatic gluconeogenesis-related proteins in HFD rats. This study suggests some therapeutic potential of VES in preventing the progression of diabetes mellitus.

    Original languageEnglish
    Pages (from-to)1122-1129
    Number of pages8
    JournalJournal of Agricultural and Food Chemistry
    Volume64
    Issue number5
    DOIs
    Publication statusPublished - 2016 Feb 10

    Keywords

    • carbohydrate metabolism
    • diabetes mellitus
    • inflammation
    • insulin resistance
    • vescalagin

    ASJC Scopus subject areas

    • General Chemistry
    • General Agricultural and Biological Sciences

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