Versatile and Accessible Magnetic Diagnosis Platform with Different Types of Magnetic Particles for Liquid and Solid Biopsies

Ju Fang Liu, Jean Hong Chen, Shu Hsien Liao, Kuen Lin Chen, Wen Chun Wei, Ting Yuan Chen, Jen Jie Chieh*, Kai Wen Huang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The diagnosis of liquid and solid biopsies by different instruments makes the clinic loading difficult in many aspects. Given the compositions of magnetic particles (MPs) with diverse characterizations and the innovative acoustic type of vibration sample magnetometer (VSM), the versatile, accessible magnetic diagnosis platform was proposed to meet clinical demands, such as low loading for multiple biopsies. In liquid biopsies of alpha-fetoprotein (AFP) standard solutions and subject serums, molecular concentration was analyzed from saturation magnetization by the soft type of Fe3O4 MPs with AFP bioprobe coating. In the phantom mixture simulated as bounded MPs in tissue, the bounded MPs was evaluated from the area of the hysteresis loop by hard type of cobalt MPs without bio-probes coating. Not only a calibration curve was founded for many hepatic cell carcinoma stages, but also microscale images verified the Ms increase due to magnetic protein clusters, etc. Hence, its wide populations in clinics could be expected.

Original languageEnglish
Article number10363
JournalInternational journal of molecular sciences
Volume24
Issue number12
DOIs
Publication statusPublished - 2023 Jun

Keywords

  • acoustic type of vibration sample magnetometer
  • liquid and solid biopsy
  • magnetic particles
  • soft and hard magnetic types

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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