Using the pleiotropic characteristics of curcumin to validate the potential application of a novel gene expression screening platform

Se Chun Liao, Hsiu Wen Hsu, Kun Lin Chuang, Zi Yi Huang, Kuan Ting Lin, Wei Hsiang Hsu, Kai Hsun Chang, Chi Yin F. Huang, Chun Li Su

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Curcumin is a polyphenol derived from curcumin longa that exhibits anticancer and anti-inflammatory properties. The consumption of foods at supernutritional levels to obtain health benefits may paradoxically result in negative health outcomes. In the present study, multiple targeting characteristics of curcumin were analyzed using our gene expression screening system, which utilized the gene expression signatures of curcumin from human hepatocellular carcinoma and colorectal cancer cells to query gene expression databases and effectively identify the molecular actions of curcumin. In agreement with prediction, curcumin inhibited NF-κB and Aurora-A, and induced G2/Marrest and apoptosis. Curcumin-suppressed NF-κB was identified through inhibition of PLCG1, PIK3R1, and MALT1 in the CD4-T-cell-receptor-signaling NF-κB cascade pathway. The results suggest that our novel gene expression screening platform is an effective method of rapidly identifying unknown biological functions and side effects of compounds with potential nutraceutical benefits.

Original languageEnglish
Article number1397
JournalNutrients
Volume11
Issue number6
DOIs
Publication statusPublished - 2019 Jun

Fingerprint

Curcumin
curcumin
screening
Gene Expression
gene expression
Polyphenols
Insurance Benefits
hepatoma
Liver Neoplasms
Dietary Supplements
T-Cell Antigen Receptor
anti-inflammatory activity
colorectal neoplasms
Transcriptome
food consumption
functional foods
Hepatocellular Carcinoma
Colorectal Neoplasms
polyphenols
Anti-Inflammatory Agents

Keywords

  • C-Map and LINCS unified environment
  • Connectivity map
  • ConsensusPathDB
  • Curcumin
  • NF-κB
  • library of integrated network-based cellular signatures

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Using the pleiotropic characteristics of curcumin to validate the potential application of a novel gene expression screening platform. / Liao, Se Chun; Hsu, Hsiu Wen; Chuang, Kun Lin; Huang, Zi Yi; Lin, Kuan Ting; Hsu, Wei Hsiang; Chang, Kai Hsun; Huang, Chi Yin F.; Su, Chun Li.

In: Nutrients, Vol. 11, No. 6, 1397, 06.2019.

Research output: Contribution to journalArticle

Liao, Se Chun ; Hsu, Hsiu Wen ; Chuang, Kun Lin ; Huang, Zi Yi ; Lin, Kuan Ting ; Hsu, Wei Hsiang ; Chang, Kai Hsun ; Huang, Chi Yin F. ; Su, Chun Li. / Using the pleiotropic characteristics of curcumin to validate the potential application of a novel gene expression screening platform. In: Nutrients. 2019 ; Vol. 11, No. 6.
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