Enterprises must use human resource management to create the difference in the fierce competition of today’s business environment. Employees are an enterprise’s most important assets, and it is important for administrators to grasp the psychology of their staff. Modern technology provided by mobile instant messaging (IM) has created a communication revolution, creating a culture of “texting rather than talking” through the use of smart phone mobile applications, such as WhatsApp, Line, and WeChat. Therefore, it is important for researchers to consider the influence of IM on work relationships and communication. This study explores the relationships between organizational trust, organizational justice, and organizational spirituality in the context of IM communication. Structural equation modeling was used to analyze questionnaire data, showing that organizational spirituality predicted organizational trust and organizational justice. The findings suggested that organizations should utilize the benefits of IM, create an organizational justice strategy, offer better human resource management, and create an environment in which employees’ organizational spirituality can be enhanced.