Use of a high-Tc SQUID-based nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate tumors in rats, by characterizing the longitudinal relaxation rate

K. W. Huang, H. H. Chen, H. C. Yang, H. E. Horng, S. H. Liao, J. J. Chieh, Y. Yang

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    This study uses a sensitive, high-Tc SQUID-detected nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate liver tumors in rats, by characterizing the longitudinal relaxation rate, T1-1. The high-Tc SQUID-based spectrometer has a spectral line width of 0.9Hz in low magnetic fields. It was found that relaxation rate for tumor tissues is (3.6 ± 0.02) s -1 and the relaxation rate for normal tissues is (7.7 ± 0.02) s-1. The difference in the longitudinal relaxation rates suggests that water structures around the DNA of cancer cells are different from those of normal tissues. The optimized detection sensitivity for the established system is 0.21 g at the present stage. It is concluded that T1-1 can be used to distinguish cancerous tissues from normal tissues. The high-Tc, SQUID-detected NMR and MRI in magnetically unshielded environments may also be useful for discriminating other tumors.

    Original languageEnglish
    Article numberP06005
    JournalJournal of Instrumentation
    Volume7
    Issue number6
    DOIs
    Publication statusPublished - 2012 Jun

    Fingerprint

    Magnetic resonance spectrometers
    SQUID
    Nuclear Magnetic Resonance
    SQUIDs
    Spectrometer
    rats
    Rats
    Tumors
    Tumor
    tumors
    Nuclear magnetic resonance
    spectrometers
    Tissue
    nuclear magnetic resonance
    spectral line width
    Linewidth
    Liver
    Cancer
    liver
    Magnetic resonance imaging

    Keywords

    • Analysis and statistical methods
    • Control and monitor systems online
    • Cryogenic detectors

    ASJC Scopus subject areas

    • Instrumentation
    • Mathematical Physics

    Cite this

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    title = "Use of a high-Tc SQUID-based nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate tumors in rats, by characterizing the longitudinal relaxation rate",
    abstract = "This study uses a sensitive, high-Tc SQUID-detected nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate liver tumors in rats, by characterizing the longitudinal relaxation rate, T1-1. The high-Tc SQUID-based spectrometer has a spectral line width of 0.9Hz in low magnetic fields. It was found that relaxation rate for tumor tissues is (3.6 ± 0.02) s -1 and the relaxation rate for normal tissues is (7.7 ± 0.02) s-1. The difference in the longitudinal relaxation rates suggests that water structures around the DNA of cancer cells are different from those of normal tissues. The optimized detection sensitivity for the established system is 0.21 g at the present stage. It is concluded that T1-1 can be used to distinguish cancerous tissues from normal tissues. The high-Tc, SQUID-detected NMR and MRI in magnetically unshielded environments may also be useful for discriminating other tumors.",
    keywords = "Analysis and statistical methods, Control and monitor systems online, Cryogenic detectors",
    author = "Huang, {K. W.} and Chen, {H. H.} and Yang, {H. C.} and Horng, {H. E.} and Liao, {S. H.} and Chieh, {J. J.} and Y. Yang",
    year = "2012",
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    T1 - Use of a high-Tc SQUID-based nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate tumors in rats, by characterizing the longitudinal relaxation rate

    AU - Huang, K. W.

    AU - Chen, H. H.

    AU - Yang, H. C.

    AU - Horng, H. E.

    AU - Liao, S. H.

    AU - Chieh, J. J.

    AU - Yang, Y.

    PY - 2012/6

    Y1 - 2012/6

    N2 - This study uses a sensitive, high-Tc SQUID-detected nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate liver tumors in rats, by characterizing the longitudinal relaxation rate, T1-1. The high-Tc SQUID-based spectrometer has a spectral line width of 0.9Hz in low magnetic fields. It was found that relaxation rate for tumor tissues is (3.6 ± 0.02) s -1 and the relaxation rate for normal tissues is (7.7 ± 0.02) s-1. The difference in the longitudinal relaxation rates suggests that water structures around the DNA of cancer cells are different from those of normal tissues. The optimized detection sensitivity for the established system is 0.21 g at the present stage. It is concluded that T1-1 can be used to distinguish cancerous tissues from normal tissues. The high-Tc, SQUID-detected NMR and MRI in magnetically unshielded environments may also be useful for discriminating other tumors.

    AB - This study uses a sensitive, high-Tc SQUID-detected nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate liver tumors in rats, by characterizing the longitudinal relaxation rate, T1-1. The high-Tc SQUID-based spectrometer has a spectral line width of 0.9Hz in low magnetic fields. It was found that relaxation rate for tumor tissues is (3.6 ± 0.02) s -1 and the relaxation rate for normal tissues is (7.7 ± 0.02) s-1. The difference in the longitudinal relaxation rates suggests that water structures around the DNA of cancer cells are different from those of normal tissues. The optimized detection sensitivity for the established system is 0.21 g at the present stage. It is concluded that T1-1 can be used to distinguish cancerous tissues from normal tissues. The high-Tc, SQUID-detected NMR and MRI in magnetically unshielded environments may also be useful for discriminating other tumors.

    KW - Analysis and statistical methods

    KW - Control and monitor systems online

    KW - Cryogenic detectors

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