Use of a high-Tc SQUID-based nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate tumors in rats, by characterizing the longitudinal relaxation rate

K. W. Huang, H. H. Chen, Hong-Chang Yang, Herng-Er Horng, Shu-Hsien Liao, Jen-Je Chieh, Y. Yang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

This study uses a sensitive, high-Tc SQUID-detected nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate liver tumors in rats, by characterizing the longitudinal relaxation rate, T1-1. The high-Tc SQUID-based spectrometer has a spectral line width of 0.9Hz in low magnetic fields. It was found that relaxation rate for tumor tissues is (3.6 ± 0.02) s -1 and the relaxation rate for normal tissues is (7.7 ± 0.02) s-1. The difference in the longitudinal relaxation rates suggests that water structures around the DNA of cancer cells are different from those of normal tissues. The optimized detection sensitivity for the established system is 0.21 g at the present stage. It is concluded that T1-1 can be used to distinguish cancerous tissues from normal tissues. The high-Tc, SQUID-detected NMR and MRI in magnetically unshielded environments may also be useful for discriminating other tumors.

Original languageEnglish
Article numberP06005
JournalJournal of Instrumentation
Volume7
Issue number6
DOIs
Publication statusPublished - 2012 Jun 1

Fingerprint

Magnetic resonance spectrometers
SQUID
Nuclear Magnetic Resonance
SQUIDs
Spectrometer
rats
Rats
Tumors
Tumor
tumors
Nuclear magnetic resonance
spectrometers
Tissue
nuclear magnetic resonance
spectral line width
Linewidth
Liver
Cancer
liver
Magnetic resonance imaging

Keywords

  • Analysis and statistical methods
  • Control and monitor systems online
  • Cryogenic detectors

ASJC Scopus subject areas

  • Mathematical Physics
  • Instrumentation

Cite this

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abstract = "This study uses a sensitive, high-Tc SQUID-detected nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate liver tumors in rats, by characterizing the longitudinal relaxation rate, T1-1. The high-Tc SQUID-based spectrometer has a spectral line width of 0.9Hz in low magnetic fields. It was found that relaxation rate for tumor tissues is (3.6 ± 0.02) s -1 and the relaxation rate for normal tissues is (7.7 ± 0.02) s-1. The difference in the longitudinal relaxation rates suggests that water structures around the DNA of cancer cells are different from those of normal tissues. The optimized detection sensitivity for the established system is 0.21 g at the present stage. It is concluded that T1-1 can be used to distinguish cancerous tissues from normal tissues. The high-Tc, SQUID-detected NMR and MRI in magnetically unshielded environments may also be useful for discriminating other tumors.",
keywords = "Analysis and statistical methods, Control and monitor systems online, Cryogenic detectors",
author = "Huang, {K. W.} and Chen, {H. H.} and Hong-Chang Yang and Herng-Er Horng and Shu-Hsien Liao and Jen-Je Chieh and Y. Yang",
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AU - Huang, K. W.

AU - Chen, H. H.

AU - Yang, Hong-Chang

AU - Horng, Herng-Er

AU - Liao, Shu-Hsien

AU - Chieh, Jen-Je

AU - Yang, Y.

PY - 2012/6/1

Y1 - 2012/6/1

N2 - This study uses a sensitive, high-Tc SQUID-detected nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate liver tumors in rats, by characterizing the longitudinal relaxation rate, T1-1. The high-Tc SQUID-based spectrometer has a spectral line width of 0.9Hz in low magnetic fields. It was found that relaxation rate for tumor tissues is (3.6 ± 0.02) s -1 and the relaxation rate for normal tissues is (7.7 ± 0.02) s-1. The difference in the longitudinal relaxation rates suggests that water structures around the DNA of cancer cells are different from those of normal tissues. The optimized detection sensitivity for the established system is 0.21 g at the present stage. It is concluded that T1-1 can be used to distinguish cancerous tissues from normal tissues. The high-Tc, SQUID-detected NMR and MRI in magnetically unshielded environments may also be useful for discriminating other tumors.

AB - This study uses a sensitive, high-Tc SQUID-detected nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate liver tumors in rats, by characterizing the longitudinal relaxation rate, T1-1. The high-Tc SQUID-based spectrometer has a spectral line width of 0.9Hz in low magnetic fields. It was found that relaxation rate for tumor tissues is (3.6 ± 0.02) s -1 and the relaxation rate for normal tissues is (7.7 ± 0.02) s-1. The difference in the longitudinal relaxation rates suggests that water structures around the DNA of cancer cells are different from those of normal tissues. The optimized detection sensitivity for the established system is 0.21 g at the present stage. It is concluded that T1-1 can be used to distinguish cancerous tissues from normal tissues. The high-Tc, SQUID-detected NMR and MRI in magnetically unshielded environments may also be useful for discriminating other tumors.

KW - Analysis and statistical methods

KW - Control and monitor systems online

KW - Cryogenic detectors

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