Universal behavior for characteristic curve of immunomagnetic reduction assay with aid of biofunctionalized magnetic nanoparticles

Chin Yih Hong; Shieh Yueh Yang; Herng Er Horng; Jen Jie Chieh; Hong Chang Yang

doi:10.1115/DETC2009-86436

Universal behavior for characteristic curve of immunomagnetic reduction assay with aid of biofunctionalized magnetic nanoparticles

Chin Yih Hong^*, Shieh Yueh Yang, Herng Er Horng, Jen Jie Chieh, Hong Chang Yang

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

By biofunctionalizing magnetic nanoparticles with bioprobes, magnetic nanoparticles are able to specifically label bio-molecules. With the association between magnetic nanoparticles and bio-molecules, the mixed-frequency AC magnetic susceptibility generated with the physical rotation of individual magnetic nanoparticles under external AC magnetic fields is reduced. This detection technology is so-called immunomagnetic reduction (IMR) assay. In the experiment, several kinds of proteins and small-molecule chemicals were detected via IMR. The characteristic curves, i.e. the reduction versus the concentration of protein/chemical, for these proteins or chemicals can be scaled to one universal curve.

Original language	English
Title of host publication	ASME 2009 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE2009
Pages	397-400
Number of pages	4
DOIs	https://doi.org/10.1115/DETC2009-86436
Publication status	Published - 2009
Event	ASME 2009 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE2009 - San Diego, CA, United States Duration: 2009 Aug 30 → 2009 Sept 2

Publication series

Name	Proceedings of the ASME Design Engineering Technical Conference
Volume	6

Other

Other	ASME 2009 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE2009
Country/Territory	United States
City	San Diego, CA
Period	2009/08/30 → 2009/09/02

ASJC Scopus subject areas

Modelling and Simulation
Mechanical Engineering
Computer Science Applications
Computer Graphics and Computer-Aided Design

Access to Document

10.1115/DETC2009-86436

Cite this

Hong, C. Y., Yang, S. Y., Horng, H. E., Chieh, J. J., & Yang, H. C. (2009). Universal behavior for characteristic curve of immunomagnetic reduction assay with aid of biofunctionalized magnetic nanoparticles. In ASME 2009 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE2009 (pp. 397-400). (Proceedings of the ASME Design Engineering Technical Conference; Vol. 6). https://doi.org/10.1115/DETC2009-86436

Universal behavior for characteristic curve of immunomagnetic reduction assay with aid of biofunctionalized magnetic nanoparticles. / Hong, Chin Yih; Yang, Shieh Yueh; Horng, Herng Er et al.
ASME 2009 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE2009. 2009. p. 397-400 (Proceedings of the ASME Design Engineering Technical Conference; Vol. 6).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Hong, CY, Yang, SY, Horng, HE , Chieh, JJ & Yang, HC 2009, Universal behavior for characteristic curve of immunomagnetic reduction assay with aid of biofunctionalized magnetic nanoparticles. in ASME 2009 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE2009. Proceedings of the ASME Design Engineering Technical Conference, vol. 6, pp. 397-400, ASME 2009 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE2009, San Diego, CA, United States, 2009/08/30. https://doi.org/10.1115/DETC2009-86436

Hong CY, Yang SY, Horng HE , Chieh JJ, Yang HC. Universal behavior for characteristic curve of immunomagnetic reduction assay with aid of biofunctionalized magnetic nanoparticles. In ASME 2009 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE2009. 2009. p. 397-400. (Proceedings of the ASME Design Engineering Technical Conference). doi: 10.1115/DETC2009-86436

Hong, Chin Yih ; Yang, Shieh Yueh ; Horng, Herng Er et al. / Universal behavior for characteristic curve of immunomagnetic reduction assay with aid of biofunctionalized magnetic nanoparticles. ASME 2009 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE2009. 2009. pp. 397-400 (Proceedings of the ASME Design Engineering Technical Conference).

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abstract = "By biofunctionalizing magnetic nanoparticles with bioprobes, magnetic nanoparticles are able to specifically label bio-molecules. With the association between magnetic nanoparticles and bio-molecules, the mixed-frequency AC magnetic susceptibility generated with the physical rotation of individual magnetic nanoparticles under external AC magnetic fields is reduced. This detection technology is so-called immunomagnetic reduction (IMR) assay. In the experiment, several kinds of proteins and small-molecule chemicals were detected via IMR. The characteristic curves, i.e. the reduction versus the concentration of protein/chemical, for these proteins or chemicals can be scaled to one universal curve.",

author = "Hong, {Chin Yih} and Yang, {Shieh Yueh} and Horng, {Herng Er} and Chieh, {Jen Jie} and Yang, {Hong Chang}",

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AB - By biofunctionalizing magnetic nanoparticles with bioprobes, magnetic nanoparticles are able to specifically label bio-molecules. With the association between magnetic nanoparticles and bio-molecules, the mixed-frequency AC magnetic susceptibility generated with the physical rotation of individual magnetic nanoparticles under external AC magnetic fields is reduced. This detection technology is so-called immunomagnetic reduction (IMR) assay. In the experiment, several kinds of proteins and small-molecule chemicals were detected via IMR. The characteristic curves, i.e. the reduction versus the concentration of protein/chemical, for these proteins or chemicals can be scaled to one universal curve.

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Universal behavior for characteristic curve of immunomagnetic reduction assay with aid of biofunctionalized magnetic nanoparticles

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