Universal behavior for characteristic curve of immunomagnetic reduction assay with aid of biofunctionalized magnetic nanoparticles

Chin Yih Hong*, Shieh Yueh Yang, Herng Er Horng, Jen Jie Chieh, Hong Chang Yang

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    By biofunctionalizing magnetic nanoparticles with bioprobes, magnetic nanoparticles are able to specifically label bio-molecules. With the association between magnetic nanoparticles and bio-molecules, the mixed-frequency AC magnetic susceptibility generated with the physical rotation of individual magnetic nanoparticles under external AC magnetic fields is reduced. This detection technology is so-called immunomagnetic reduction (IMR) assay. In the experiment, several kinds of proteins and small-molecule chemicals were detected via IMR. The characteristic curves, i.e. the reduction versus the concentration of protein/chemical, for these proteins or chemicals can be scaled to one universal curve.

    Original languageEnglish
    Title of host publicationASME 2009 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE2009
    Pages397-400
    Number of pages4
    DOIs
    Publication statusPublished - 2009 Dec 1
    EventASME 2009 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE2009 - San Diego, CA, United States
    Duration: 2009 Aug 302009 Sep 2

    Publication series

    NameProceedings of the ASME Design Engineering Technical Conference
    Volume6

    Other

    OtherASME 2009 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE2009
    Country/TerritoryUnited States
    CitySan Diego, CA
    Period2009/08/302009/09/02

    ASJC Scopus subject areas

    • Modelling and Simulation
    • Mechanical Engineering
    • Computer Science Applications
    • Computer Graphics and Computer-Aided Design

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