Uncoupling of upper airway motor activity from phrenic bursting by positive end-expired pressure in the rat

Kun Ze Lee, David D. Fuller, Li Chu Tung, I. Jung Lu, Li Chi Ku, Ji Chuu Hwang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Phasic bursting in the hypoglossal nerve can be uncoupled from phrenic bursting by application of positive end-expired pressure (PEEP). We wished to determine whether similar uncoupling can also be induced in other respiratory-modulated upper airway (UAW) motor outputs. Discharge of the facial, hypoglossal, superior laryngeal, recurrent laryngeal, and phrenic nerves was recorded in anesthetized, ventilated rats during stepwise changes in PEEP with a normocapnic, hyperoxic background. Application of 3- to 6-cmH2O PEEP caused the onset inspiratory (I) UAW nerve bursting to precede the phrenic burst but did not uncouple bursting. In contrast, application of 9- to 12-cmH2O PEEP uncoupled UAW neurograms such that rhythmic bursting occurred during periods of phrenic quiescence. Single-fiber recording experiments were conducted to determine whether a specific population of UAW motoneurons is recruited during uncoupled bursting. The data indicate that expiratory-inspiratory (EI) motoneurons remained active, while I motoneurons did not fire during uncoupled UAW bursting. Finally, we examined the relationship between motoneuron discharge rate and PEEP during coupled UAW and phrenic bursting. EI discharge rate was linearly related to PEEP during preinspiration, but showed no relationship to PEEP during inspiration. Our results demonstrate that multiple UAW motor outputs can be uncoupled from phrenic bursting, and this response is associated with bursting of EI nerve fibers. The relationship between PEEP and EI motoneuron discharge rate differs during preinspiratory and I periods; this may indicate that bursting during these phases of the respiratory cycle is controlled by distinct neuronal outputs.

Original languageEnglish
Pages (from-to)878-889
Number of pages12
JournalJournal of Applied Physiology
Volume102
Issue number3
DOIs
Publication statusPublished - 2007 Mar 1

Fingerprint

Diaphragm
Motor Activity
Motor Neurons
Pressure
Hypoglossal Nerve
Recurrent Laryngeal Nerve
Phrenic Nerve
Positive-Pressure Respiration
Nerve Fibers
Population

Keywords

  • Expiratory-inspiratory
  • Motoneurons
  • Preinspiratory
  • Uncoupled activity

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Uncoupling of upper airway motor activity from phrenic bursting by positive end-expired pressure in the rat. / Lee, Kun Ze; Fuller, David D.; Tung, Li Chu; Lu, I. Jung; Ku, Li Chi; Hwang, Ji Chuu.

In: Journal of Applied Physiology, Vol. 102, No. 3, 01.03.2007, p. 878-889.

Research output: Contribution to journalArticle

Lee, Kun Ze ; Fuller, David D. ; Tung, Li Chu ; Lu, I. Jung ; Ku, Li Chi ; Hwang, Ji Chuu. / Uncoupling of upper airway motor activity from phrenic bursting by positive end-expired pressure in the rat. In: Journal of Applied Physiology. 2007 ; Vol. 102, No. 3. pp. 878-889.
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