Ultrasound-Induced Magnetic Imaging of Tumors Targeted by Biofunctional Magnetic Nanoparticles

Kai Wen Huang, Jen-Je Chieh, Chih Kuang Yeh, Shu-Hsien Liao, Yi Yan Lee, Pei Yi Hsiao, Wen Chun Wei, Hong Chang Yang, Herng-Er Horng

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    Biofunctional magnetic nanoparticles (MNPs) have been widely applied in biomedical engineering. MNPs are used as a contrast medium in magnetic imaging. Current methods of magnetic imaging, such as magnetic particle imaging and magnetic relaxometry, use small amounts of MNPs at target points far from the surface of the patient's body; these methods always consume considerable power to produce magnetic fields of high uniformity or gradient excitations. Some drawbacks, such as a limited imaging region, imaging system shielding, and complex algorithms based on assumptions of MNP properties or environmental factors, also limit the application of MNP methods in clinics. Therefore, this work proposes an interdisciplinary methodology of ultrasound-induced magnetic imaging that lacks these drawbacks. In the proposed imaging method, magnet sets were designed with uniform magnetic fields to magnetize MNPs. Besides, magnetized MNPs are subjected to ultrasound vibrations; the motion of the MNPs induces weak induction voltages at the imaging pickup coils. The highly sensitive scanning superconducting quantum interference device biosusceptometry with three sets of ultrasound focus chips was developed to construct magnetic tomography at three depths. A phantom test showed favorable consistency between the visual photos and the magnetic images of alpha-fetoprotein antibody (anti-AFP) MNP distribution on gauzes. In animal tests, rats with liver tumors were imaged at the pre-injection and post-injection of anti-AFP MNPs. The consistent results of magnetic images and ultrasound images implied that the proposed method has high clinical potential.

    Original languageEnglish
    Pages (from-to)3030-3037
    Number of pages8
    JournalACS Nano
    Volume11
    Issue number3
    DOIs
    Publication statusPublished - 2017 Mar 28

    Fingerprint

    Tumors
    tumors
    Ultrasonics
    Nanoparticles
    Imaging techniques
    nanoparticles
    gauze
    injection
    Magnetic fields
    Contrast media
    Biomedical engineering
    Pickups
    SQUIDs
    alpha-Fetoproteins
    antibodies
    liver
    magnetic fields
    Antibodies
    Liver
    Imaging systems

    Keywords

    • alpha-fetoprotein
    • magnetic nanoparticles
    • superconducting quantum interference device
    • tumors
    • ultrasound-induced magnetic imaging

    ASJC Scopus subject areas

    • Materials Science(all)
    • Engineering(all)
    • Physics and Astronomy(all)

    Cite this

    Ultrasound-Induced Magnetic Imaging of Tumors Targeted by Biofunctional Magnetic Nanoparticles. / Huang, Kai Wen; Chieh, Jen-Je; Yeh, Chih Kuang; Liao, Shu-Hsien; Lee, Yi Yan; Hsiao, Pei Yi; Wei, Wen Chun; Yang, Hong Chang; Horng, Herng-Er.

    In: ACS Nano, Vol. 11, No. 3, 28.03.2017, p. 3030-3037.

    Research output: Contribution to journalArticle

    Huang, Kai Wen ; Chieh, Jen-Je ; Yeh, Chih Kuang ; Liao, Shu-Hsien ; Lee, Yi Yan ; Hsiao, Pei Yi ; Wei, Wen Chun ; Yang, Hong Chang ; Horng, Herng-Er. / Ultrasound-Induced Magnetic Imaging of Tumors Targeted by Biofunctional Magnetic Nanoparticles. In: ACS Nano. 2017 ; Vol. 11, No. 3. pp. 3030-3037.
    @article{2d6e408cd4544005b75b847a02337000,
    title = "Ultrasound-Induced Magnetic Imaging of Tumors Targeted by Biofunctional Magnetic Nanoparticles",
    abstract = "Biofunctional magnetic nanoparticles (MNPs) have been widely applied in biomedical engineering. MNPs are used as a contrast medium in magnetic imaging. Current methods of magnetic imaging, such as magnetic particle imaging and magnetic relaxometry, use small amounts of MNPs at target points far from the surface of the patient's body; these methods always consume considerable power to produce magnetic fields of high uniformity or gradient excitations. Some drawbacks, such as a limited imaging region, imaging system shielding, and complex algorithms based on assumptions of MNP properties or environmental factors, also limit the application of MNP methods in clinics. Therefore, this work proposes an interdisciplinary methodology of ultrasound-induced magnetic imaging that lacks these drawbacks. In the proposed imaging method, magnet sets were designed with uniform magnetic fields to magnetize MNPs. Besides, magnetized MNPs are subjected to ultrasound vibrations; the motion of the MNPs induces weak induction voltages at the imaging pickup coils. The highly sensitive scanning superconducting quantum interference device biosusceptometry with three sets of ultrasound focus chips was developed to construct magnetic tomography at three depths. A phantom test showed favorable consistency between the visual photos and the magnetic images of alpha-fetoprotein antibody (anti-AFP) MNP distribution on gauzes. In animal tests, rats with liver tumors were imaged at the pre-injection and post-injection of anti-AFP MNPs. The consistent results of magnetic images and ultrasound images implied that the proposed method has high clinical potential.",
    keywords = "alpha-fetoprotein, magnetic nanoparticles, superconducting quantum interference device, tumors, ultrasound-induced magnetic imaging",
    author = "Huang, {Kai Wen} and Jen-Je Chieh and Yeh, {Chih Kuang} and Shu-Hsien Liao and Lee, {Yi Yan} and Hsiao, {Pei Yi} and Wei, {Wen Chun} and Yang, {Hong Chang} and Herng-Er Horng",
    year = "2017",
    month = "3",
    day = "28",
    doi = "10.1021/acsnano.6b08730",
    language = "English",
    volume = "11",
    pages = "3030--3037",
    journal = "ACS Nano",
    issn = "1936-0851",
    publisher = "American Chemical Society",
    number = "3",

    }

    TY - JOUR

    T1 - Ultrasound-Induced Magnetic Imaging of Tumors Targeted by Biofunctional Magnetic Nanoparticles

    AU - Huang, Kai Wen

    AU - Chieh, Jen-Je

    AU - Yeh, Chih Kuang

    AU - Liao, Shu-Hsien

    AU - Lee, Yi Yan

    AU - Hsiao, Pei Yi

    AU - Wei, Wen Chun

    AU - Yang, Hong Chang

    AU - Horng, Herng-Er

    PY - 2017/3/28

    Y1 - 2017/3/28

    N2 - Biofunctional magnetic nanoparticles (MNPs) have been widely applied in biomedical engineering. MNPs are used as a contrast medium in magnetic imaging. Current methods of magnetic imaging, such as magnetic particle imaging and magnetic relaxometry, use small amounts of MNPs at target points far from the surface of the patient's body; these methods always consume considerable power to produce magnetic fields of high uniformity or gradient excitations. Some drawbacks, such as a limited imaging region, imaging system shielding, and complex algorithms based on assumptions of MNP properties or environmental factors, also limit the application of MNP methods in clinics. Therefore, this work proposes an interdisciplinary methodology of ultrasound-induced magnetic imaging that lacks these drawbacks. In the proposed imaging method, magnet sets were designed with uniform magnetic fields to magnetize MNPs. Besides, magnetized MNPs are subjected to ultrasound vibrations; the motion of the MNPs induces weak induction voltages at the imaging pickup coils. The highly sensitive scanning superconducting quantum interference device biosusceptometry with three sets of ultrasound focus chips was developed to construct magnetic tomography at three depths. A phantom test showed favorable consistency between the visual photos and the magnetic images of alpha-fetoprotein antibody (anti-AFP) MNP distribution on gauzes. In animal tests, rats with liver tumors were imaged at the pre-injection and post-injection of anti-AFP MNPs. The consistent results of magnetic images and ultrasound images implied that the proposed method has high clinical potential.

    AB - Biofunctional magnetic nanoparticles (MNPs) have been widely applied in biomedical engineering. MNPs are used as a contrast medium in magnetic imaging. Current methods of magnetic imaging, such as magnetic particle imaging and magnetic relaxometry, use small amounts of MNPs at target points far from the surface of the patient's body; these methods always consume considerable power to produce magnetic fields of high uniformity or gradient excitations. Some drawbacks, such as a limited imaging region, imaging system shielding, and complex algorithms based on assumptions of MNP properties or environmental factors, also limit the application of MNP methods in clinics. Therefore, this work proposes an interdisciplinary methodology of ultrasound-induced magnetic imaging that lacks these drawbacks. In the proposed imaging method, magnet sets were designed with uniform magnetic fields to magnetize MNPs. Besides, magnetized MNPs are subjected to ultrasound vibrations; the motion of the MNPs induces weak induction voltages at the imaging pickup coils. The highly sensitive scanning superconducting quantum interference device biosusceptometry with three sets of ultrasound focus chips was developed to construct magnetic tomography at three depths. A phantom test showed favorable consistency between the visual photos and the magnetic images of alpha-fetoprotein antibody (anti-AFP) MNP distribution on gauzes. In animal tests, rats with liver tumors were imaged at the pre-injection and post-injection of anti-AFP MNPs. The consistent results of magnetic images and ultrasound images implied that the proposed method has high clinical potential.

    KW - alpha-fetoprotein

    KW - magnetic nanoparticles

    KW - superconducting quantum interference device

    KW - tumors

    KW - ultrasound-induced magnetic imaging

    UR - http://www.scopus.com/inward/record.url?scp=85016406300&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=85016406300&partnerID=8YFLogxK

    U2 - 10.1021/acsnano.6b08730

    DO - 10.1021/acsnano.6b08730

    M3 - Article

    C2 - 28276684

    AN - SCOPUS:85016406300

    VL - 11

    SP - 3030

    EP - 3037

    JO - ACS Nano

    JF - ACS Nano

    SN - 1936-0851

    IS - 3

    ER -