Ultra-highly sensitive and wash-free bio-detection of H5N1 virus by immunomagnetic reduction assays

S. Y. Yang, J. J. Chieh, W. C. Wang, C. Y. Yu, C. B. Lan, J. H. Chen, H. E. Horng, Chin Yih Hong, H. C. Yang, Wilber Huang

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A platform for assaying avian influenza H5N1 viruses that involves measuring the ac immunomagnetic reduction of a magnetic reagent mixed with a detected sample is developed. The magnetic reagent contained magnetic nanoparticles coated with antibodies. To achieve an ultra-high sensitivity assay, a system utilizing a high-transition-temperature superconducting quantum interference device was used to sense the immunomagnetic reduction of the reagents. The results confirmed the ultra-high sensitivity of the immunomagnetic reduction assay on H5N1.

Original languageEnglish
Pages (from-to)250-252
Number of pages3
JournalJournal of Virological Methods
Issue number2
Publication statusPublished - 2008 Nov 1



  • H5N1
  • Immunomagnetic reduction
  • Magnetic nanoparticles

ASJC Scopus subject areas

  • Virology

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