Tumor necrosis factor-α promoter polymorphism is associated with the risk of Parkinson's disease

Yih Ru Wu; I. Hsin Feng; Rong Kuo Lyu; Kuo Hsuan Chang; Yu Yun Lin; Huiling Chan; Fen Ju Hu; Guey Jen Lee-Chen; Chiung Mei Chen

doi:10.1002/ajmg.b.30435

Tumor necrosis factor-α promoter polymorphism is associated with the risk of Parkinson's disease

Yih Ru Wu, I. Hsin Feng, Rong Kuo Lyu, Kuo Hsuan Chang, Yu Yun Lin, Huiling Chan, Fen Ju Hu, Guey Jen Lee-Chen^*, Chiung Mei Chen

^*Corresponding author for this work

Department of Life Science

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Inflammatory events may contribute to the pathogenesis of Parkinson's disease (PD). We conducted a case-control study in a cohort of 369 PD cases and another cohort of 326 ethnically matched controls to investigate the association of tumor necrosis factor-α (TNF-α) promoter single nucleotide polymorphisms (SNPs) with the risk of PD. The overall genotype distribution at T-1031C and C-857T sites showed significant difference between PD cases and controls (P = 0.0082 and 0.0035, respectively). However, only the more frequent -1031 CC genotype was evidently associated with PD (P = 0.0085, odds ratio: 2.98; 95% CI: 1.38-7.09). Pairwise SNP linkage disequilibrium showed -1031 and -863 sites are in strong linkage disequilibrium (D′ = 0.93, Δ² = 0.80). Pairwise haplotype analysis among the four sites showed that -1031C-863A may act as a risk haplotype among PD cases (P = 0.0028, odds ratio: 2.18; 95% CI: 1.33-3.69).

Original language	English
Pages (from-to)	300-304
Number of pages	5
Journal	American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume	144
Issue number	3
DOIs	https://doi.org/10.1002/ajmg.b.30435
Publication status	Published - 2007 Apr 5

Keywords

Disease association
Parkinson's disease
Promoter SNPs
TNF-α

ASJC Scopus subject areas

Genetics(clinical)
Psychiatry and Mental health
Cellular and Molecular Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ajmg.b.30435

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title = "Tumor necrosis factor-α promoter polymorphism is associated with the risk of Parkinson's disease",

abstract = "Inflammatory events may contribute to the pathogenesis of Parkinson's disease (PD). We conducted a case-control study in a cohort of 369 PD cases and another cohort of 326 ethnically matched controls to investigate the association of tumor necrosis factor-α (TNF-α) promoter single nucleotide polymorphisms (SNPs) with the risk of PD. The overall genotype distribution at T-1031C and C-857T sites showed significant difference between PD cases and controls (P = 0.0082 and 0.0035, respectively). However, only the more frequent -1031 CC genotype was evidently associated with PD (P = 0.0085, odds ratio: 2.98; 95% CI: 1.38-7.09). Pairwise SNP linkage disequilibrium showed -1031 and -863 sites are in strong linkage disequilibrium (D′ = 0.93, Δ2 = 0.80). Pairwise haplotype analysis among the four sites showed that -1031C-863A may act as a risk haplotype among PD cases (P = 0.0028, odds ratio: 2.18; 95% CI: 1.33-3.69).",

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author = "Wu, {Yih Ru} and Feng, {I. Hsin} and Lyu, {Rong Kuo} and Chang, {Kuo Hsuan} and Lin, {Yu Yun} and Huiling Chan and Hu, {Fen Ju} and Lee-Chen, {Guey Jen} and Chen, {Chiung Mei}",

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AU - Feng, I. Hsin

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AU - Lin, Yu Yun

AU - Chan, Huiling

AU - Hu, Fen Ju

AU - Lee-Chen, Guey Jen

AU - Chen, Chiung Mei

PY - 2007/4/5

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N2 - Inflammatory events may contribute to the pathogenesis of Parkinson's disease (PD). We conducted a case-control study in a cohort of 369 PD cases and another cohort of 326 ethnically matched controls to investigate the association of tumor necrosis factor-α (TNF-α) promoter single nucleotide polymorphisms (SNPs) with the risk of PD. The overall genotype distribution at T-1031C and C-857T sites showed significant difference between PD cases and controls (P = 0.0082 and 0.0035, respectively). However, only the more frequent -1031 CC genotype was evidently associated with PD (P = 0.0085, odds ratio: 2.98; 95% CI: 1.38-7.09). Pairwise SNP linkage disequilibrium showed -1031 and -863 sites are in strong linkage disequilibrium (D′ = 0.93, Δ2 = 0.80). Pairwise haplotype analysis among the four sites showed that -1031C-863A may act as a risk haplotype among PD cases (P = 0.0028, odds ratio: 2.18; 95% CI: 1.33-3.69).

AB - Inflammatory events may contribute to the pathogenesis of Parkinson's disease (PD). We conducted a case-control study in a cohort of 369 PD cases and another cohort of 326 ethnically matched controls to investigate the association of tumor necrosis factor-α (TNF-α) promoter single nucleotide polymorphisms (SNPs) with the risk of PD. The overall genotype distribution at T-1031C and C-857T sites showed significant difference between PD cases and controls (P = 0.0082 and 0.0035, respectively). However, only the more frequent -1031 CC genotype was evidently associated with PD (P = 0.0085, odds ratio: 2.98; 95% CI: 1.38-7.09). Pairwise SNP linkage disequilibrium showed -1031 and -863 sites are in strong linkage disequilibrium (D′ = 0.93, Δ2 = 0.80). Pairwise haplotype analysis among the four sites showed that -1031C-863A may act as a risk haplotype among PD cases (P = 0.0028, odds ratio: 2.18; 95% CI: 1.33-3.69).

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Tumor necrosis factor-α promoter polymorphism is associated with the risk of Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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