Tumor necrosis factor-α promoter polymorphism is associated with the risk of Parkinson's disease

Yih Ru Wu, I. Hsin Feng, Rong Kuo Lyu, Kuo Hsuan Chang, Yu Yun Lin, Huiling Chan, Fen Ju Hu, Guey-Jen Lee, Chiung Mei Chen

Research output: Contribution to journalArticle

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Abstract

Inflammatory events may contribute to the pathogenesis of Parkinson's disease (PD). We conducted a case-control study in a cohort of 369 PD cases and another cohort of 326 ethnically matched controls to investigate the association of tumor necrosis factor-α (TNF-α) promoter single nucleotide polymorphisms (SNPs) with the risk of PD. The overall genotype distribution at T-1031C and C-857T sites showed significant difference between PD cases and controls (P = 0.0082 and 0.0035, respectively). However, only the more frequent -1031 CC genotype was evidently associated with PD (P = 0.0085, odds ratio: 2.98; 95% CI: 1.38-7.09). Pairwise SNP linkage disequilibrium showed -1031 and -863 sites are in strong linkage disequilibrium (D′ = 0.93, Δ2 = 0.80). Pairwise haplotype analysis among the four sites showed that -1031C-863A may act as a risk haplotype among PD cases (P = 0.0028, odds ratio: 2.18; 95% CI: 1.33-3.69).

Original languageEnglish
Pages (from-to)300-304
Number of pages5
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume144
Issue number3
DOIs
Publication statusPublished - 2007 Apr 5

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Parkinson Disease
Tumor Necrosis Factor-alpha
Linkage Disequilibrium
Haplotypes
Single Nucleotide Polymorphism
Odds Ratio
Genotype
Case-Control Studies

Keywords

  • Disease association
  • Parkinson's disease
  • Promoter SNPs
  • TNF-α

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Tumor necrosis factor-α promoter polymorphism is associated with the risk of Parkinson's disease. / Wu, Yih Ru; Feng, I. Hsin; Lyu, Rong Kuo; Chang, Kuo Hsuan; Lin, Yu Yun; Chan, Huiling; Hu, Fen Ju; Lee, Guey-Jen; Chen, Chiung Mei.

In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol. 144, No. 3, 05.04.2007, p. 300-304.

Research output: Contribution to journalArticle

Wu, Yih Ru ; Feng, I. Hsin ; Lyu, Rong Kuo ; Chang, Kuo Hsuan ; Lin, Yu Yun ; Chan, Huiling ; Hu, Fen Ju ; Lee, Guey-Jen ; Chen, Chiung Mei. / Tumor necrosis factor-α promoter polymorphism is associated with the risk of Parkinson's disease. In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2007 ; Vol. 144, No. 3. pp. 300-304.
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