Abstract
A simple and efficient trifluoromethanesulfonic acid-catalyzed cycloisomerization of arylpropagylsulfonamide-tethered 2,3-epoxycyclohexan-1-ols is described. The cyclization proceeds via tandem semi-pinacol rearrangement/alkyne-aldehyde metathesis to afford spiropiperidines under mild reaction conditions.
| Original language | English |
|---|---|
| Pages (from-to) | 3290-3294 |
| Number of pages | 5 |
| Journal | Advanced Synthesis and Catalysis |
| Volume | 353 |
| Issue number | 18 |
| DOIs | |
| Publication status | Published - 2011 Dec |
Keywords
- alkyne/aldehyde metathesis
- semi-pinacol rearrangement
- spiropiperidines
- tandem reactions
- triflic acid
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry
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Dive into the research topics of 'Trifluoromethanesulfonic acid-catalyzed tandem semi-pinacol rearrangement/alkyne-aldehyde metathesis reaction of arylpropagylsulfonamide- tethered 2,3-epoxycyclohexan-1-ols to spiropiperidines'. Together they form a unique fingerprint.Datasets
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CCDC 835097: Experimental Crystal Structure Determination
Lin, M. (Creator), Wu, S. (Creator) & Yeh, M. P. (Creator), Unknown Publisher, 2012
DOI: 10.5517/ccx0zmh, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccx0zmh&sid=DataCite
Dataset
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CCDC 835096: Experimental Crystal Structure Determination
Lin, M. (Creator), Wu, S. (Creator) & Yeh, M. P. (Creator), Unknown Publisher, 2012
DOI: 10.5517/ccx0zlg, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccx0zlg&sid=DataCite
Dataset