Traditional Chinese herbal formula relieves snoring by modulating activities of upper airway related nerves in aged rats

Kou Toung Chung, Chih Hsiang Hsu, Ching Lung Lin, Sheue Er Wang, Chung Hsin Wu

Research output: Contribution to journalArticle

Abstract

Aim: The present study investigated whether intraperitoneal treatment with the herbal formula B210 ([B210]; a herbal composition of Gastrodia elata and Cinnamomum cassia) can reduce snoring in aged rats. Also, we studied possible neural mechanisms involved in B210 treatment and subsequent reduced snoring in rats. Methods and result: We compared pressure and frequency of snoring, activities of phrenic nerve (PNA), activities of recurrent laryngeal nerve (RLNA) and activities of hypoglossal nerve (HNA), inspiratory time (TI) and expiratory time (TE) of PNA, and pre-inspiratory time (Pre-TI) of HNA in aged rats between sham and B210 treatment groups (30 mg/mL dissolved in DMSO). We found that aged rats that received B210 treatment had significantly reduced pressure and frequency of snoring than rats who received sham treatment. Also, we observed that aged rats that received B210 treatment had significantly increased PNA, RLNA, and HNA, extended TI and TE of PNA, and prolonged Pre-TI of HNA compared to rats that received sham treatment. In other words, B210 treatment may relieve snoring through modulating activities and breathing time of upper airway related nerves in aged rats. Conclusion: We suggested that the B210 might be a potential herbal formula for snoring remission.

Original languageEnglish
Pages (from-to)1165-1171
Number of pages7
JournalDrug Design, Development and Therapy
Volume12
DOIs
Publication statusPublished - 2018 May 8

Keywords

  • Chinese herbal medicine
  • Hypoglossal nerve
  • Phrenic nerve
  • Recurrent laryngeal nerve
  • Snoring remission
  • Upper airway

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

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