Toxicokinetics/toxicodynamics with damage feedback improves risk assessment for tilapia and freshwater clam exposed to arsenic

Wei Yu Chen, Chung Min Liao, Yun Ru Ju, Sher Singh, Li John Jou, Bo Ching Chen, Jeng Wei Tsai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

It has been proposed that irreversible responses of organisms exposed to contaminants are due to a systemslevel feedback. Here we tested this hypothesis by reanalyzing the published data on toxicokinetics and survival probability based on a systems-level threshold damage model (TDM) incorporating with a positive damage feedback to explore the steady-state response and dynamic behavior of damage for tilapia and freshwater clam exposed to waterborne arsenic (As). We found that ultrasensitivity appeared in As-tilapia and freshwater clam systems with Hill coefficient n C 4, indicating that the positive damage feedback mechanism has been triggered. We confirmed that damage can trigger a positive feedback loop that together with As stressor increases irreversibility. This study also showed that TDM with positive feedback gave a much better predictability than that of TDM at As concentrations ranging from 100 to 500 mg l-1 for freshwater clam, whereas for tilapia, two models had nearly same performance on predictability. We suggested that mortality-time profile derived Hill coefficient could be used as a new risk indicator to assess the survival probability for species exposed to waterborne metals. We anticipated that the proposed toxicokinetics/toxicodynamics with a positive damage feedback may facilitate our understanding and manipulation of complex mechanisms of metal susceptibility among species and improve current risk assessment strategies.

Original languageEnglish
Pages (from-to)485-495
Number of pages11
JournalEcotoxicology
Volume21
Issue number2
DOIs
Publication statusPublished - 2012 Mar 1

Fingerprint

Tilapia
Bivalvia
Arsenic
Fresh Water
Risk assessment
arsenic
risk assessment
Feedback
damage
Coordination Complexes
Toxicokinetics
feedback mechanism
metal
Metals
Impurities
Mortality
mortality
pollutant

Keywords

  • Arsenic
  • Damage feedback
  • Ecotoxicology
  • Freshwater Clam
  • Tilapia
  • Toxicodynamics
  • Toxicokinetics

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Management, Monitoring, Policy and Law
  • Medicine(all)

Cite this

Toxicokinetics/toxicodynamics with damage feedback improves risk assessment for tilapia and freshwater clam exposed to arsenic. / Chen, Wei Yu; Liao, Chung Min; Ju, Yun Ru; Singh, Sher; Jou, Li John; Chen, Bo Ching; Tsai, Jeng Wei.

In: Ecotoxicology, Vol. 21, No. 2, 01.03.2012, p. 485-495.

Research output: Contribution to journalArticle

Chen, Wei Yu ; Liao, Chung Min ; Ju, Yun Ru ; Singh, Sher ; Jou, Li John ; Chen, Bo Ching ; Tsai, Jeng Wei. / Toxicokinetics/toxicodynamics with damage feedback improves risk assessment for tilapia and freshwater clam exposed to arsenic. In: Ecotoxicology. 2012 ; Vol. 21, No. 2. pp. 485-495.
@article{346df92eda39479cb0caeae7ffeae937,
title = "Toxicokinetics/toxicodynamics with damage feedback improves risk assessment for tilapia and freshwater clam exposed to arsenic",
abstract = "It has been proposed that irreversible responses of organisms exposed to contaminants are due to a systemslevel feedback. Here we tested this hypothesis by reanalyzing the published data on toxicokinetics and survival probability based on a systems-level threshold damage model (TDM) incorporating with a positive damage feedback to explore the steady-state response and dynamic behavior of damage for tilapia and freshwater clam exposed to waterborne arsenic (As). We found that ultrasensitivity appeared in As-tilapia and freshwater clam systems with Hill coefficient n C 4, indicating that the positive damage feedback mechanism has been triggered. We confirmed that damage can trigger a positive feedback loop that together with As stressor increases irreversibility. This study also showed that TDM with positive feedback gave a much better predictability than that of TDM at As concentrations ranging from 100 to 500 mg l-1 for freshwater clam, whereas for tilapia, two models had nearly same performance on predictability. We suggested that mortality-time profile derived Hill coefficient could be used as a new risk indicator to assess the survival probability for species exposed to waterborne metals. We anticipated that the proposed toxicokinetics/toxicodynamics with a positive damage feedback may facilitate our understanding and manipulation of complex mechanisms of metal susceptibility among species and improve current risk assessment strategies.",
keywords = "Arsenic, Damage feedback, Ecotoxicology, Freshwater Clam, Tilapia, Toxicodynamics, Toxicokinetics",
author = "Chen, {Wei Yu} and Liao, {Chung Min} and Ju, {Yun Ru} and Sher Singh and Jou, {Li John} and Chen, {Bo Ching} and Tsai, {Jeng Wei}",
year = "2012",
month = "3",
day = "1",
doi = "10.1007/s10646-011-0810-2",
language = "English",
volume = "21",
pages = "485--495",
journal = "Ecotoxicology",
issn = "0963-9292",
publisher = "Springer Netherlands",
number = "2",

}

TY - JOUR

T1 - Toxicokinetics/toxicodynamics with damage feedback improves risk assessment for tilapia and freshwater clam exposed to arsenic

AU - Chen, Wei Yu

AU - Liao, Chung Min

AU - Ju, Yun Ru

AU - Singh, Sher

AU - Jou, Li John

AU - Chen, Bo Ching

AU - Tsai, Jeng Wei

PY - 2012/3/1

Y1 - 2012/3/1

N2 - It has been proposed that irreversible responses of organisms exposed to contaminants are due to a systemslevel feedback. Here we tested this hypothesis by reanalyzing the published data on toxicokinetics and survival probability based on a systems-level threshold damage model (TDM) incorporating with a positive damage feedback to explore the steady-state response and dynamic behavior of damage for tilapia and freshwater clam exposed to waterborne arsenic (As). We found that ultrasensitivity appeared in As-tilapia and freshwater clam systems with Hill coefficient n C 4, indicating that the positive damage feedback mechanism has been triggered. We confirmed that damage can trigger a positive feedback loop that together with As stressor increases irreversibility. This study also showed that TDM with positive feedback gave a much better predictability than that of TDM at As concentrations ranging from 100 to 500 mg l-1 for freshwater clam, whereas for tilapia, two models had nearly same performance on predictability. We suggested that mortality-time profile derived Hill coefficient could be used as a new risk indicator to assess the survival probability for species exposed to waterborne metals. We anticipated that the proposed toxicokinetics/toxicodynamics with a positive damage feedback may facilitate our understanding and manipulation of complex mechanisms of metal susceptibility among species and improve current risk assessment strategies.

AB - It has been proposed that irreversible responses of organisms exposed to contaminants are due to a systemslevel feedback. Here we tested this hypothesis by reanalyzing the published data on toxicokinetics and survival probability based on a systems-level threshold damage model (TDM) incorporating with a positive damage feedback to explore the steady-state response and dynamic behavior of damage for tilapia and freshwater clam exposed to waterborne arsenic (As). We found that ultrasensitivity appeared in As-tilapia and freshwater clam systems with Hill coefficient n C 4, indicating that the positive damage feedback mechanism has been triggered. We confirmed that damage can trigger a positive feedback loop that together with As stressor increases irreversibility. This study also showed that TDM with positive feedback gave a much better predictability than that of TDM at As concentrations ranging from 100 to 500 mg l-1 for freshwater clam, whereas for tilapia, two models had nearly same performance on predictability. We suggested that mortality-time profile derived Hill coefficient could be used as a new risk indicator to assess the survival probability for species exposed to waterborne metals. We anticipated that the proposed toxicokinetics/toxicodynamics with a positive damage feedback may facilitate our understanding and manipulation of complex mechanisms of metal susceptibility among species and improve current risk assessment strategies.

KW - Arsenic

KW - Damage feedback

KW - Ecotoxicology

KW - Freshwater Clam

KW - Tilapia

KW - Toxicodynamics

KW - Toxicokinetics

UR - http://www.scopus.com/inward/record.url?scp=84861660608&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861660608&partnerID=8YFLogxK

U2 - 10.1007/s10646-011-0810-2

DO - 10.1007/s10646-011-0810-2

M3 - Article

C2 - 22045293

AN - SCOPUS:84861660608

VL - 21

SP - 485

EP - 495

JO - Ecotoxicology

JF - Ecotoxicology

SN - 0963-9292

IS - 2

ER -