Toward synthetic analogues of linked redox and catalytic multimetal sites in proteins: A model of the histidine-cysteine bridged dicopper array

Way Zen Lee, William B. Tolman

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22 Citations (Scopus)

Abstract

Contiguous HisCys residues link a type 1 Cu electron-transfer site to a catalytic Cu-containing site in nitrite reductase and the multicopper oxidases. In efforts to understand the role of the linker in these multimetallic arrays and to design new catalysts, a mixed-valent dicopper complex comprising a bridging thiolate/N-donor ligand that models the CuHisCysCu motif was prepared and characterized by X-ray crystallography. Comparison of spectroscopic and cyclic voltammetry data to those of the mononuclear analogues of each portion of the complex, LCuSCPh3 and LCu-(py) (L = β-diketiminate, py = pyridyl), confirmed retention of the dicopper structure in solution.

Original languageEnglish
Pages (from-to)5656-5658
Number of pages3
JournalInorganic Chemistry
Volume41
Issue number22
DOIs
Publication statusPublished - 2002 Nov 4

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ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

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