To Transfer or Not to Transfer? Development of a Dinitrosyl Iron Complex as a Nitroxyl Donor for the Nitroxylation of an FeIII-Porphyrin Center

Yu Ting Tseng; Chien Hong Chen; Jing Yu Lin; Bing Han Li; Yu Huan Lu; Chia Her Lin; Hsin Tsung Chen; Tsu Chien Weng; Dimosthenes Sokaras; Huang Yeh Chen; Yun Liang Soo; Tsai Te Lu

doi:10.1002/chem.201503176

To Transfer or Not to Transfer? Development of a Dinitrosyl Iron Complex as a Nitroxyl Donor for the Nitroxylation of an Fe^III-Porphyrin Center

Yu Ting Tseng, Chien Hong Chen, Jing Yu Lin, Bing Han Li, Yu Huan Lu, Chia Her Lin, Hsin Tsung Chen, Tsu Chien Weng, Dimosthenes Sokaras, Huang Yeh Chen, Yun Liang Soo, Tsai Te Lu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

A positive myocardial inotropic effect achieved using HNO/NO^-, compared with NO· triggered attempts to explore novel nitroxyl donors for use in clinical applications in vascular and myocardial pharmacology. To develop M-NO complexes for nitroxyl chemistry and biology, modulation of direct nitroxyl-transfer reactivity of dinitrosyl iron complexes (DNICs) is investigated in this study using a Fe^III-porphyrin complex and proteins as a specific probe. Stable dinuclear {Fe(NO)₂}⁹ DNIC [Fe(μ-^MePyr)(NO)₂]₂ was discovered as a potent nitroxyl donor for nitroxylation of Fe^III-heme centers through an associative mechanism. Beyond the efficient nitroxyl transfer, transformation of DNICs into a chemical biology probe for nitroxyl and for pharmaceutical applications demands further efforts using in vitro/in vivo studies. A dinitrosyl iron complex, DNIC [Fe(μ-^MePyr)(NO)₂]₂, was found to be a potent nitroxyl donor for prospective clinical applications in vascular and myocardial pharmacology.

Original language	English
Pages (from-to)	17570-17573
Number of pages	4
Journal	Chemistry - A European Journal
Volume	21
Issue number	49
DOIs	https://doi.org/10.1002/chem.201503176
Publication status	Published - 2015 Dec 1
Externally published	Yes

Keywords

X-ray emission spectroscopy
bioinorganic chemistry
nitrosyl complexes
nitroxyl

ASJC Scopus subject areas

Catalysis
Organic Chemistry

Access to Document

10.1002/chem.201503176

Cite this

Tseng, Y. T., Chen, C. H., Lin, J. Y., Li, B. H., Lu, Y. H., Lin, C. H., Chen, H. T., Weng, T. C., Sokaras, D., Chen, H. Y., Soo, Y. L., & Lu, T. T. (2015). To Transfer or Not to Transfer? Development of a Dinitrosyl Iron Complex as a Nitroxyl Donor for the Nitroxylation of an Fe^III-Porphyrin Center. Chemistry - A European Journal, 21(49), 17570-17573. https://doi.org/10.1002/chem.201503176

Tseng, YT, Chen, CH, Lin, JY, Li, BH, Lu, YH, Lin, CH, Chen, HT, Weng, TC, Sokaras, D, Chen, HY, Soo, YL & Lu, TT 2015, 'To Transfer or Not to Transfer? Development of a Dinitrosyl Iron Complex as a Nitroxyl Donor for the Nitroxylation of an Fe^III-Porphyrin Center', Chemistry - A European Journal, vol. 21, no. 49, pp. 17570-17573. https://doi.org/10.1002/chem.201503176

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abstract = "A positive myocardial inotropic effect achieved using HNO/NO-, compared with NO· triggered attempts to explore novel nitroxyl donors for use in clinical applications in vascular and myocardial pharmacology. To develop M-NO complexes for nitroxyl chemistry and biology, modulation of direct nitroxyl-transfer reactivity of dinitrosyl iron complexes (DNICs) is investigated in this study using a FeIII-porphyrin complex and proteins as a specific probe. Stable dinuclear {Fe(NO)2}9 DNIC [Fe(μ-MePyr)(NO)2]2 was discovered as a potent nitroxyl donor for nitroxylation of FeIII-heme centers through an associative mechanism. Beyond the efficient nitroxyl transfer, transformation of DNICs into a chemical biology probe for nitroxyl and for pharmaceutical applications demands further efforts using in vitro/in vivo studies. A dinitrosyl iron complex, DNIC [Fe(μ-MePyr)(NO)2]2, was found to be a potent nitroxyl donor for prospective clinical applications in vascular and myocardial pharmacology.",

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