To Transfer or Not to Transfer? Development of a Dinitrosyl Iron Complex as a Nitroxyl Donor for the Nitroxylation of an FeIII-Porphyrin Center

Yu Ting Tseng, Chien Hong Chen, Jing Yu Lin, Bing Han Li, Yu Huan Lu, Chia Her Lin, Hsin Tsung Chen, Tsu Chien Weng, Dimosthenes Sokaras, Huang Yeh Chen, Yun Liang Soo, Tsai Te Lu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

A positive myocardial inotropic effect achieved using HNO/NO-, compared with NO· triggered attempts to explore novel nitroxyl donors for use in clinical applications in vascular and myocardial pharmacology. To develop M-NO complexes for nitroxyl chemistry and biology, modulation of direct nitroxyl-transfer reactivity of dinitrosyl iron complexes (DNICs) is investigated in this study using a FeIII-porphyrin complex and proteins as a specific probe. Stable dinuclear {Fe(NO)2}9 DNIC [Fe(μ-MePyr)(NO)2]2 was discovered as a potent nitroxyl donor for nitroxylation of FeIII-heme centers through an associative mechanism. Beyond the efficient nitroxyl transfer, transformation of DNICs into a chemical biology probe for nitroxyl and for pharmaceutical applications demands further efforts using in vitro/in vivo studies. A dinitrosyl iron complex, DNIC [Fe(μ-MePyr)(NO)2]2, was found to be a potent nitroxyl donor for prospective clinical applications in vascular and myocardial pharmacology.

Original languageEnglish
Pages (from-to)17570-17573
Number of pages4
JournalChemistry - A European Journal
Volume21
Issue number49
DOIs
Publication statusPublished - 2015 Dec 1
Externally publishedYes

Keywords

  • bioinorganic chemistry
  • nitrosyl complexes
  • nitroxyl
  • X-ray emission spectroscopy

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'To Transfer or Not to Transfer? Development of a Dinitrosyl Iron Complex as a Nitroxyl Donor for the Nitroxylation of an Fe<sup>III</sup>-Porphyrin Center'. Together they form a unique fingerprint.

Cite this