Therapeutic potential of traditional chinese medicine on inflammatory diseases

Wen Hsin Tsai, Chih Ching Yang, Ping Chia Li, Wang Chuan Chen, Chiang Ting Chien

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Increased oxidative stress induces inflammation to several tissues/organs leading to cell death and long-term injury. Traditional Chinese Medicine (TCM) with antioxidant, anti-inflammatory, anti-apoptotic, and autophagic regulatory functions has been widely used as preventive or therapeutic strategy in modern medicine. Oxidative stress and inflammation have been widely reported to contribute to cigarette smoke-induced lung inflammation, hepatotoxicity, or sympathetic activation-induced liver inflammation, lipopolysaccharide-induced renal inflammation, and substance P-mediated neurogenic hyperactive bladder based on clinical findings. In this review, we introduce several evidences for TCM treatment including Monascus adlay (MA) produced by inoculating adlay (Cois lachrymal-jobi L. var. ma-yuen Stapf) with Monascus purpureus on lung injury, Amla (Emblica officinalis Gaertn. of Euphorbiaceae family) on hepatotoxin-induced liver inflammation, Virgate Wormwood Decoction (Yīn Chén Hāo tāng) and its active component genipin on sympathetic activation-induced liver inflammation, and green tea extract and its active components, catechins, or a modified TCM formula Five Stranguries Powder (Wǔ Lín Sǎn) plus Crataegi Fructus (Shān Zhā) on hyperactive bladder. The pathophysiologic and molecular mechanisms of TCM on ameliorating inflammatory diseases are discussed in the review.

Original languageEnglish
Pages (from-to)142-151
Number of pages10
JournalJournal of Traditional and Complementary Medicine
Volume3
Issue number3
DOIs
Publication statusPublished - 2013 Jan 1

Keywords

  • Apoptosis
  • Autophagy
  • Endoplasmic reticulum stress
  • Inflammation
  • Oxidative stress
  • Traditional Chinese Medicine

ASJC Scopus subject areas

  • Complementary and alternative medicine

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