Theory for the bending rigidity of protein-coated lipid membranes

C. M. Chen

doi:10.1016/S0378-4371(00)00037-6

Theory for the bending rigidity of protein-coated lipid membranes

C. M. Chen^*

^*Corresponding author for this work

Department of Physics

Research output: Contribution to journal › Conference article › peer-review

13 Citations (Scopus)

Abstract

We study the bending rigidity of protein-coated lipid bilayer membranes by a continuum Landau theory. For up-down symmetric membrane proteins, the bending rigidity (κ) of the membrane is found to increase linearly with protein fraction (φ) and coupling strength (λ) due to the coupling between membrane curvature and local protein fraction. We estimate the coupling strength as λ ∝ κa_p²/a_l², where a_p and a_l are the lateral sizes of proteins and lipids, respectively. Estimated values of λ/κ are given for various combinations of membrane proteins and lipids. We show that the presence of membrane proteins leads to thinning of the effective membrane thickness and reduces the mean layer spacing of a stack of bilayers.

Original language	English
Pages (from-to)	41-50
Number of pages	10
Journal	Physica A: Statistical Mechanics and its Applications
Volume	281
Issue number	1
DOIs	https://doi.org/10.1016/S0378-4371(00)00037-6
Publication status	Published - 2000 Jun 15
Event	5th Taiwan International Symposium on Statistical Physics (StatPhys-Taiwan-1999) - Taipei, Taiwan Duration: 1999 Aug 9 → 1999 Aug 12

ASJC Scopus subject areas

Statistics and Probability
Condensed Matter Physics

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10.1016/S0378-4371(00)00037-6

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title = "Theory for the bending rigidity of protein-coated lipid membranes",

abstract = "We study the bending rigidity of protein-coated lipid bilayer membranes by a continuum Landau theory. For up-down symmetric membrane proteins, the bending rigidity (κ) of the membrane is found to increase linearly with protein fraction (φ) and coupling strength (λ) due to the coupling between membrane curvature and local protein fraction. We estimate the coupling strength as λ ∝ κap2/al2, where ap and al are the lateral sizes of proteins and lipids, respectively. Estimated values of λ/κ are given for various combinations of membrane proteins and lipids. We show that the presence of membrane proteins leads to thinning of the effective membrane thickness and reduces the mean layer spacing of a stack of bilayers.",

author = "Chen, \{C. M.\}",

note = "Funding Information: We thank P.G. Higgs, F.C. MacKintosh, and P.D. Olmsted for stimulating interactions. This work was supported by National Science Council of ROC under grant number NSC 89-2112-M-003-001.; 5th Taiwan International Symposium on Statistical Physics (StatPhys-Taiwan-1999) ; Conference date: 09-08-1999 Through 12-08-1999",

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TY - JOUR

T1 - Theory for the bending rigidity of protein-coated lipid membranes

AU - Chen, C. M.

N1 - Funding Information: We thank P.G. Higgs, F.C. MacKintosh, and P.D. Olmsted for stimulating interactions. This work was supported by National Science Council of ROC under grant number NSC 89-2112-M-003-001.

PY - 2000/6/15

Y1 - 2000/6/15

N2 - We study the bending rigidity of protein-coated lipid bilayer membranes by a continuum Landau theory. For up-down symmetric membrane proteins, the bending rigidity (κ) of the membrane is found to increase linearly with protein fraction (φ) and coupling strength (λ) due to the coupling between membrane curvature and local protein fraction. We estimate the coupling strength as λ ∝ κap2/al2, where ap and al are the lateral sizes of proteins and lipids, respectively. Estimated values of λ/κ are given for various combinations of membrane proteins and lipids. We show that the presence of membrane proteins leads to thinning of the effective membrane thickness and reduces the mean layer spacing of a stack of bilayers.

AB - We study the bending rigidity of protein-coated lipid bilayer membranes by a continuum Landau theory. For up-down symmetric membrane proteins, the bending rigidity (κ) of the membrane is found to increase linearly with protein fraction (φ) and coupling strength (λ) due to the coupling between membrane curvature and local protein fraction. We estimate the coupling strength as λ ∝ κap2/al2, where ap and al are the lateral sizes of proteins and lipids, respectively. Estimated values of λ/κ are given for various combinations of membrane proteins and lipids. We show that the presence of membrane proteins leads to thinning of the effective membrane thickness and reduces the mean layer spacing of a stack of bilayers.

UR - https://www.scopus.com/pages/publications/0033686372

UR - https://www.scopus.com/pages/publications/0033686372#tab=citedBy

U2 - 10.1016/S0378-4371(00)00037-6

DO - 10.1016/S0378-4371(00)00037-6

M3 - Conference article

AN - SCOPUS:0033686372

SN - 0378-4371

VL - 281

SP - 41

EP - 50

JO - Physica A: Statistical Mechanics and its Applications

JF - Physica A: Statistical Mechanics and its Applications

IS - 1

T2 - 5th Taiwan International Symposium on Statistical Physics (StatPhys-Taiwan-1999)

Y2 - 9 August 1999 through 12 August 1999

ER -

Theory for the bending rigidity of protein-coated lipid membranes

Abstract

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