Theoretical study of the impact of ion acceleration parameters on the mass resolving power in linear MALDI time-of-flight mass spectrometry

Yi Hong Cai, Cheng Huang Lin, Yi Sheng Wang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

This work examines how ion acceleration parameters affect the mass resolving power (Rm) of linear time-of-flight (TOF) mass spectrometry (MS). Ion acceleration parameters have been considered as playing a minor role in determining the Rm in TOF MS. Based on results in two-dimensional topological space calculated in this work, we demonstrate that the length and electrical potential of the ion acceleration region critically affect Rm. The flight-time distribution of ions of m/z 3000 in a 3-m long linear TOF mass spectrometer is analyzed using the coupled space-velocity focusing method. Big data analysis reveals that four types of flight-time distribution are available by adjusting ion acceleration length. The coefficients in the equation of flight-time spread can be used to predict the best length for achieving highest performance. The results show an 18-fold increase in Rm when increasing the length of the ion acceleration region by a factor of ∼35 with respect to conventional design. Adjusting ion extraction parameters cannot provide the same magnitude of improvement. Correlation between Rm and critical experimental parameters are discussed.

Original languageEnglish
Article number116756
JournalInternational Journal of Mass Spectrometry
Volume471
DOIs
Publication statusPublished - 2022 Jan

Keywords

  • Comprehensive calculation
  • Flight-time distribution
  • Flight-time topology
  • Ion acceleration
  • Linear TOF
  • Mass resolving power

ASJC Scopus subject areas

  • Instrumentation
  • Condensed Matter Physics
  • Spectroscopy
  • Physical and Theoretical Chemistry

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