The stability of source localization in a whole-head magnetoencephalography system demonstrated by auditory evoked field measurements

Kuen Lin Chen, Hong Chang Yang, Sung Ying Tsai, Yu Wei Liu, Shu Hsien Liao, Herng Er Horng, Yong Ho Lee, Hyukchan Kwon

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Superconducting quantum interference device (SQUID), which is a very sensitive magnetic sensor, has been widely used to detect the ultra-small magnetic signals in many different territories, especially in the biomagnetic measurement. In this study, a 128-channel SQUID first-order axial gradiometer system for whole-head magnetoencephalography (MEG) measurements was setup to characterize the auditory evoked magnetic fields (AEFs). A 500 Hz monaural pure tone persisting 425 ms with the sound pressure level of 80 dB was randomly applied to the left ear of subject with the inter-stimulus interval of 1.5 ∼ 2.8 s to prevent fatigue of nerves. We demonstrated the characteristic waveforms of AEFs can be accurately recorded and analyzed. Using source localization processes, the origins of AEFs were successfully calculated to be at the auditory cortices which are brain areas known for responsive to sound stimulus. A phantom experiment also proved the good localization accuracy of the established MEG system and measurement procedures. The validated performance of the SQUID system suggests that this technique can also be employed in other brain research.

Original languageEnglish
Article number074702
JournalJournal of Applied Physics
Volume110
Issue number7
DOIs
Publication statusPublished - 2011 Oct 1

Fingerprint

interference
stimuli
brain
magnetic fields
magnetic signals
gradiometers
cortexes
nerves
ear
sound pressure
waveforms
intervals
acoustics
sensors

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

The stability of source localization in a whole-head magnetoencephalography system demonstrated by auditory evoked field measurements. / Chen, Kuen Lin; Yang, Hong Chang; Tsai, Sung Ying; Liu, Yu Wei; Liao, Shu Hsien; Horng, Herng Er; Lee, Yong Ho; Kwon, Hyukchan.

In: Journal of Applied Physics, Vol. 110, No. 7, 074702, 01.10.2011.

Research output: Contribution to journalArticle

Chen, Kuen Lin ; Yang, Hong Chang ; Tsai, Sung Ying ; Liu, Yu Wei ; Liao, Shu Hsien ; Horng, Herng Er ; Lee, Yong Ho ; Kwon, Hyukchan. / The stability of source localization in a whole-head magnetoencephalography system demonstrated by auditory evoked field measurements. In: Journal of Applied Physics. 2011 ; Vol. 110, No. 7.
@article{42e4d156347346199fbe0840abe1fb0c,
title = "The stability of source localization in a whole-head magnetoencephalography system demonstrated by auditory evoked field measurements",
abstract = "Superconducting quantum interference device (SQUID), which is a very sensitive magnetic sensor, has been widely used to detect the ultra-small magnetic signals in many different territories, especially in the biomagnetic measurement. In this study, a 128-channel SQUID first-order axial gradiometer system for whole-head magnetoencephalography (MEG) measurements was setup to characterize the auditory evoked magnetic fields (AEFs). A 500 Hz monaural pure tone persisting 425 ms with the sound pressure level of 80 dB was randomly applied to the left ear of subject with the inter-stimulus interval of 1.5 ∼ 2.8 s to prevent fatigue of nerves. We demonstrated the characteristic waveforms of AEFs can be accurately recorded and analyzed. Using source localization processes, the origins of AEFs were successfully calculated to be at the auditory cortices which are brain areas known for responsive to sound stimulus. A phantom experiment also proved the good localization accuracy of the established MEG system and measurement procedures. The validated performance of the SQUID system suggests that this technique can also be employed in other brain research.",
author = "Chen, {Kuen Lin} and Yang, {Hong Chang} and Tsai, {Sung Ying} and Liu, {Yu Wei} and Liao, {Shu Hsien} and Horng, {Herng Er} and Lee, {Yong Ho} and Hyukchan Kwon",
year = "2011",
month = "10",
day = "1",
doi = "10.1063/1.3641991",
language = "English",
volume = "110",
journal = "Journal of Applied Physics",
issn = "0021-8979",
publisher = "American Institute of Physics Publising LLC",
number = "7",

}

TY - JOUR

T1 - The stability of source localization in a whole-head magnetoencephalography system demonstrated by auditory evoked field measurements

AU - Chen, Kuen Lin

AU - Yang, Hong Chang

AU - Tsai, Sung Ying

AU - Liu, Yu Wei

AU - Liao, Shu Hsien

AU - Horng, Herng Er

AU - Lee, Yong Ho

AU - Kwon, Hyukchan

PY - 2011/10/1

Y1 - 2011/10/1

N2 - Superconducting quantum interference device (SQUID), which is a very sensitive magnetic sensor, has been widely used to detect the ultra-small magnetic signals in many different territories, especially in the biomagnetic measurement. In this study, a 128-channel SQUID first-order axial gradiometer system for whole-head magnetoencephalography (MEG) measurements was setup to characterize the auditory evoked magnetic fields (AEFs). A 500 Hz monaural pure tone persisting 425 ms with the sound pressure level of 80 dB was randomly applied to the left ear of subject with the inter-stimulus interval of 1.5 ∼ 2.8 s to prevent fatigue of nerves. We demonstrated the characteristic waveforms of AEFs can be accurately recorded and analyzed. Using source localization processes, the origins of AEFs were successfully calculated to be at the auditory cortices which are brain areas known for responsive to sound stimulus. A phantom experiment also proved the good localization accuracy of the established MEG system and measurement procedures. The validated performance of the SQUID system suggests that this technique can also be employed in other brain research.

AB - Superconducting quantum interference device (SQUID), which is a very sensitive magnetic sensor, has been widely used to detect the ultra-small magnetic signals in many different territories, especially in the biomagnetic measurement. In this study, a 128-channel SQUID first-order axial gradiometer system for whole-head magnetoencephalography (MEG) measurements was setup to characterize the auditory evoked magnetic fields (AEFs). A 500 Hz monaural pure tone persisting 425 ms with the sound pressure level of 80 dB was randomly applied to the left ear of subject with the inter-stimulus interval of 1.5 ∼ 2.8 s to prevent fatigue of nerves. We demonstrated the characteristic waveforms of AEFs can be accurately recorded and analyzed. Using source localization processes, the origins of AEFs were successfully calculated to be at the auditory cortices which are brain areas known for responsive to sound stimulus. A phantom experiment also proved the good localization accuracy of the established MEG system and measurement procedures. The validated performance of the SQUID system suggests that this technique can also be employed in other brain research.

UR - http://www.scopus.com/inward/record.url?scp=80054983126&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054983126&partnerID=8YFLogxK

U2 - 10.1063/1.3641991

DO - 10.1063/1.3641991

M3 - Article

AN - SCOPUS:80054983126

VL - 110

JO - Journal of Applied Physics

JF - Journal of Applied Physics

SN - 0021-8979

IS - 7

M1 - 074702

ER -