This study was conducted to explore the relationships among science-related major students' information commitment, mental load and mental effort. The sample included 314 college students in Taiwan. The correlation analysis revealed the obvious relationships between ICs and mental load. Students who have sophisticated information commitment tended to experience low mental load. On the other hand, students who have superficial information commitment experienced more mental load. The finding was suggested that students may need an appropriate training for learning in the web-based environment with information seeking activities indispensably. Educators could help students develop superior searching strategy and the ability of information commitment to reduce the experience of cognitive load.