The PdCl2-catalyzed sequential heterocyclization/Michael addition cascade in the synthesis of 2,3-disubstituted indoles

Donala Janreddy, Veerababurao Kavala, Chun Wei Kuo, Ting Shen Kuo, Chiu Hui He, Ching-Fa Yao

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A cascade reaction of 2-N-unprotected-2-alkynylanilines and various electron-deficient alkenes in the presence of PdCl2 provided 2,3-disubstituted indole derivatives, whereas, in the presence of Pd(OAc) 2, the same reaction resulted in the production of N-alkylated-2-alkynylaniline derivatives.

Original languageEnglish
Pages (from-to)3323-3330
Number of pages8
JournalTetrahedron
Volume69
Issue number15
DOIs
Publication statusPublished - 2013 Apr 15

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Indoles
Alkenes
Electrons
Derivatives
indole
palladium(II) acetate
palladium chloride

Keywords

  • 2,3-Disubstituted indoles
  • 2-Alkynylanilines
  • Cascade reaction
  • PdCl
  • α,β-Unsaturated ketones

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

The PdCl2-catalyzed sequential heterocyclization/Michael addition cascade in the synthesis of 2,3-disubstituted indoles. / Janreddy, Donala; Kavala, Veerababurao; Kuo, Chun Wei; Kuo, Ting Shen; He, Chiu Hui; Yao, Ching-Fa.

In: Tetrahedron, Vol. 69, No. 15, 15.04.2013, p. 3323-3330.

Research output: Contribution to journalArticle

Janreddy, Donala ; Kavala, Veerababurao ; Kuo, Chun Wei ; Kuo, Ting Shen ; He, Chiu Hui ; Yao, Ching-Fa. / The PdCl2-catalyzed sequential heterocyclization/Michael addition cascade in the synthesis of 2,3-disubstituted indoles. In: Tetrahedron. 2013 ; Vol. 69, No. 15. pp. 3323-3330.
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AU - He, Chiu Hui

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