The PdCl2-catalyzed sequential heterocyclization/Michael addition cascade in the synthesis of 2,3-disubstituted indoles

Donala Janreddy, Veerababurao Kavala, Chun Wei Kuo, Ting Shen Kuo, Chiu Hui He, Ching Fa Yao

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A cascade reaction of 2-N-unprotected-2-alkynylanilines and various electron-deficient alkenes in the presence of PdCl2 provided 2,3-disubstituted indole derivatives, whereas, in the presence of Pd(OAc) 2, the same reaction resulted in the production of N-alkylated-2-alkynylaniline derivatives.

Original languageEnglish
Pages (from-to)3323-3330
Number of pages8
JournalTetrahedron
Volume69
Issue number15
DOIs
Publication statusPublished - 2013 Apr 15

Keywords

  • 2,3-Disubstituted indoles
  • 2-Alkynylanilines
  • Cascade reaction
  • PdCl
  • α,β-Unsaturated ketones

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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