The interaction between acute oligomer Aβ1-40 and stress severely impaired spatial learning and memory

Hei Jen Huang, Keng Chen Liang, Yen Yu Chang, Hsing Chieh Ke, Jia Yu Lin, Hsiu Mei Hsieh

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In this study, we investigated whether stress can enhance the toxicity of oligomer Aβ1-40 in the mouse brain. Stress was applied to the animals, consisting of a 2-day inescapable foot shock followed by 3-weekly situation reminders (SRs). We found that stress significantly affected not only the amygdala-dependent (anxiety) but also the hippocampal-dependent (spatial learning and memory) behaviors through the oxidative damage caused in these two regions. However, oligomer Aβ1-40 treatment alone did not induce behavioral impairment. In addition, combined oligomer Aβ1-40 and stress treatment increased the glucocorticoid receptor (GR)/mineralocorticoid receptor (MR) ratio and the expression of corticotrophin releasing factor 1 (CRF-1) receptor in the hippocampus. Changes in the components of the hypothalamic-pituitary-adrenal (HPA) axis, such as the GR/MR ratio and CRF-1 level, were observed, accompanied by increasing Aβ accumulation, oxidative stress, nuclear transcription factor (NF-κB) hypoactivity, and apoptotic signaling in the hippocampus, and decreasing calbindin D28K and NMDA receptor 2A/2B (NR2A/2B) in the hippocampus, along with alteration of the cholinergic neurons (ChAT) in the medium septum/diagnoid band (MS/DB), noradrenergic neurons (TH) in the locus coeruleus (LC), and serotonergic neurons (5-HT) in the Raphe nucleus. Therefore, apoptosis and synaptic dysfunction in the hippocampus severely induced the impairment of spatial learning and memory. These results suggest that stress may play an important role in the early stages of Alzheimer's disease (AD), and an antioxidant strategy might be a potential therapeutic approach for stress-mediated disorders.

Original languageEnglish
Pages (from-to)8-18
Number of pages11
JournalNeurobiology of Learning and Memory
Volume93
Issue number1
DOIs
Publication statusPublished - 2010 Jan 1

Fingerprint

Hippocampus
Mineralocorticoid Receptors
Glucocorticoid Receptors
Calbindin 1
Serotonergic Neurons
Adrenergic Neurons
Cholinergic Neurons
Raphe Nuclei
Locus Coeruleus
Corticotropin-Releasing Hormone
Amygdala
Foot
Shock
Serotonin
Alzheimer Disease
Oxidative Stress
Transcription Factors
Anxiety
Antioxidants
Apoptosis

Keywords

  • GR/MR ratio
  • Olgomer Aβ
  • Oxidative stress
  • Spatial learning and memory
  • Stress

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

Cite this

The interaction between acute oligomer Aβ1-40 and stress severely impaired spatial learning and memory. / Huang, Hei Jen; Liang, Keng Chen; Chang, Yen Yu; Ke, Hsing Chieh; Lin, Jia Yu; Hsieh, Hsiu Mei.

In: Neurobiology of Learning and Memory, Vol. 93, No. 1, 01.01.2010, p. 8-18.

Research output: Contribution to journalArticle

Huang, Hei Jen ; Liang, Keng Chen ; Chang, Yen Yu ; Ke, Hsing Chieh ; Lin, Jia Yu ; Hsieh, Hsiu Mei. / The interaction between acute oligomer Aβ1-40 and stress severely impaired spatial learning and memory. In: Neurobiology of Learning and Memory. 2010 ; Vol. 93, No. 1. pp. 8-18.
@article{fc68d88fa3ed4790acc68cb221d2c9e9,
title = "The interaction between acute oligomer Aβ1-40 and stress severely impaired spatial learning and memory",
abstract = "In this study, we investigated whether stress can enhance the toxicity of oligomer Aβ1-40 in the mouse brain. Stress was applied to the animals, consisting of a 2-day inescapable foot shock followed by 3-weekly situation reminders (SRs). We found that stress significantly affected not only the amygdala-dependent (anxiety) but also the hippocampal-dependent (spatial learning and memory) behaviors through the oxidative damage caused in these two regions. However, oligomer Aβ1-40 treatment alone did not induce behavioral impairment. In addition, combined oligomer Aβ1-40 and stress treatment increased the glucocorticoid receptor (GR)/mineralocorticoid receptor (MR) ratio and the expression of corticotrophin releasing factor 1 (CRF-1) receptor in the hippocampus. Changes in the components of the hypothalamic-pituitary-adrenal (HPA) axis, such as the GR/MR ratio and CRF-1 level, were observed, accompanied by increasing Aβ accumulation, oxidative stress, nuclear transcription factor (NF-κB) hypoactivity, and apoptotic signaling in the hippocampus, and decreasing calbindin D28K and NMDA receptor 2A/2B (NR2A/2B) in the hippocampus, along with alteration of the cholinergic neurons (ChAT) in the medium septum/diagnoid band (MS/DB), noradrenergic neurons (TH) in the locus coeruleus (LC), and serotonergic neurons (5-HT) in the Raphe nucleus. Therefore, apoptosis and synaptic dysfunction in the hippocampus severely induced the impairment of spatial learning and memory. These results suggest that stress may play an important role in the early stages of Alzheimer's disease (AD), and an antioxidant strategy might be a potential therapeutic approach for stress-mediated disorders.",
keywords = "GR/MR ratio, Olgomer Aβ, Oxidative stress, Spatial learning and memory, Stress",
author = "Huang, {Hei Jen} and Liang, {Keng Chen} and Chang, {Yen Yu} and Ke, {Hsing Chieh} and Lin, {Jia Yu} and Hsieh, {Hsiu Mei}",
year = "2010",
month = "1",
day = "1",
doi = "10.1016/j.nlm.2009.07.010",
language = "English",
volume = "93",
pages = "8--18",
journal = "Neurobiology of Learning and Memory",
issn = "1074-7427",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - The interaction between acute oligomer Aβ1-40 and stress severely impaired spatial learning and memory

AU - Huang, Hei Jen

AU - Liang, Keng Chen

AU - Chang, Yen Yu

AU - Ke, Hsing Chieh

AU - Lin, Jia Yu

AU - Hsieh, Hsiu Mei

PY - 2010/1/1

Y1 - 2010/1/1

N2 - In this study, we investigated whether stress can enhance the toxicity of oligomer Aβ1-40 in the mouse brain. Stress was applied to the animals, consisting of a 2-day inescapable foot shock followed by 3-weekly situation reminders (SRs). We found that stress significantly affected not only the amygdala-dependent (anxiety) but also the hippocampal-dependent (spatial learning and memory) behaviors through the oxidative damage caused in these two regions. However, oligomer Aβ1-40 treatment alone did not induce behavioral impairment. In addition, combined oligomer Aβ1-40 and stress treatment increased the glucocorticoid receptor (GR)/mineralocorticoid receptor (MR) ratio and the expression of corticotrophin releasing factor 1 (CRF-1) receptor in the hippocampus. Changes in the components of the hypothalamic-pituitary-adrenal (HPA) axis, such as the GR/MR ratio and CRF-1 level, were observed, accompanied by increasing Aβ accumulation, oxidative stress, nuclear transcription factor (NF-κB) hypoactivity, and apoptotic signaling in the hippocampus, and decreasing calbindin D28K and NMDA receptor 2A/2B (NR2A/2B) in the hippocampus, along with alteration of the cholinergic neurons (ChAT) in the medium septum/diagnoid band (MS/DB), noradrenergic neurons (TH) in the locus coeruleus (LC), and serotonergic neurons (5-HT) in the Raphe nucleus. Therefore, apoptosis and synaptic dysfunction in the hippocampus severely induced the impairment of spatial learning and memory. These results suggest that stress may play an important role in the early stages of Alzheimer's disease (AD), and an antioxidant strategy might be a potential therapeutic approach for stress-mediated disorders.

AB - In this study, we investigated whether stress can enhance the toxicity of oligomer Aβ1-40 in the mouse brain. Stress was applied to the animals, consisting of a 2-day inescapable foot shock followed by 3-weekly situation reminders (SRs). We found that stress significantly affected not only the amygdala-dependent (anxiety) but also the hippocampal-dependent (spatial learning and memory) behaviors through the oxidative damage caused in these two regions. However, oligomer Aβ1-40 treatment alone did not induce behavioral impairment. In addition, combined oligomer Aβ1-40 and stress treatment increased the glucocorticoid receptor (GR)/mineralocorticoid receptor (MR) ratio and the expression of corticotrophin releasing factor 1 (CRF-1) receptor in the hippocampus. Changes in the components of the hypothalamic-pituitary-adrenal (HPA) axis, such as the GR/MR ratio and CRF-1 level, were observed, accompanied by increasing Aβ accumulation, oxidative stress, nuclear transcription factor (NF-κB) hypoactivity, and apoptotic signaling in the hippocampus, and decreasing calbindin D28K and NMDA receptor 2A/2B (NR2A/2B) in the hippocampus, along with alteration of the cholinergic neurons (ChAT) in the medium septum/diagnoid band (MS/DB), noradrenergic neurons (TH) in the locus coeruleus (LC), and serotonergic neurons (5-HT) in the Raphe nucleus. Therefore, apoptosis and synaptic dysfunction in the hippocampus severely induced the impairment of spatial learning and memory. These results suggest that stress may play an important role in the early stages of Alzheimer's disease (AD), and an antioxidant strategy might be a potential therapeutic approach for stress-mediated disorders.

KW - GR/MR ratio

KW - Olgomer Aβ

KW - Oxidative stress

KW - Spatial learning and memory

KW - Stress

UR - http://www.scopus.com/inward/record.url?scp=74649087306&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74649087306&partnerID=8YFLogxK

U2 - 10.1016/j.nlm.2009.07.010

DO - 10.1016/j.nlm.2009.07.010

M3 - Article

C2 - 19660564

AN - SCOPUS:74649087306

VL - 93

SP - 8

EP - 18

JO - Neurobiology of Learning and Memory

JF - Neurobiology of Learning and Memory

SN - 1074-7427

IS - 1

ER -