The influence of sex on cognitive insight and neurocognitive functioning in schizophrenia

Yu Chen Kao, Yia Ping Liu, Yin Ju Lien, Shwu Jon Lin, Chien Wen Lu, Tzong Shi Wang, Ching Hui Loh

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Both impaired insight and cognitive deficits in schizophrenia are core features of this disorder. Previous studies have demonstrated the complex relationships between neurocognition and cognitive insight, as well as the contribution of neurocognition in explaining cognitive insight. However, there is lack of research regarding the influences of sex on the relation of neurocognition and cognitive insight. The present study sought to elucidate sex differences in cognitive insight and neurocognition in schizophrenia. Seventy three outpatients (male= 39) with DSM-IV diagnosis of schizophrenia or schizoaffective disorder were enrolled in the cross-sectional study. The participants were assessed with cognitive insight using the Beck Cognitive Insight Scale, executive functions using the Wisconsin Card Sorting Test, sustained attention using the Conner's Continuous Performance Test (Second Edition), and intelligence using the Wechsler Adult Intelligence Scale-Third version, respectively. Sex differences in demographic and clinical variables were small; nevertheless, female patients had significantly later age of illness onset and higher levels of formal education than males (p. <. 0.05). Poor cognitive insight was attributed to impairment in performance of executive function and sustained attention. Results from hierarchical regression analyses indicated sex as a moderator only in the association between cognitive insight and executive function. Our findings support an association between poor cognitive insight and neurocognitive impairment in outpatients with schizophrenia and suggest that the relationship may be sex-specific. This study highlights potential targets for effective intervention and rehabilitation in improving patients' insight toward mental illness.

Original languageEnglish
Pages (from-to)193-200
Number of pages8
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume44
DOIs
Publication statusPublished - 2013 Jul 1

Fingerprint

Schizophrenia
Executive Function
Intelligence
Sex Characteristics
Outpatients
Age of Onset
Diagnostic and Statistical Manual of Mental Disorders
Psychotic Disorders
Cognition
Rehabilitation
Cross-Sectional Studies
Regression Analysis
Demography
Education
Research

Keywords

  • Beck Cognitive Insight Scale
  • Continuous Performance Test
  • Intelligence Scale-Third version
  • Moderator
  • Wisconsin Card Sorting Test

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

Cite this

The influence of sex on cognitive insight and neurocognitive functioning in schizophrenia. / Kao, Yu Chen; Liu, Yia Ping; Lien, Yin Ju; Lin, Shwu Jon; Lu, Chien Wen; Wang, Tzong Shi; Loh, Ching Hui.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 44, 01.07.2013, p. 193-200.

Research output: Contribution to journalArticle

Kao, Yu Chen ; Liu, Yia Ping ; Lien, Yin Ju ; Lin, Shwu Jon ; Lu, Chien Wen ; Wang, Tzong Shi ; Loh, Ching Hui. / The influence of sex on cognitive insight and neurocognitive functioning in schizophrenia. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2013 ; Vol. 44. pp. 193-200.
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