The indole compound NC009-1 inhibits aggregation and promotes neurite outgrowth through enhancement of HSPB1 in SCA17 cells and ameliorates the behavioral deficits in SCA17 mice

Medicine & Life Sciences

• NC009-1 compound 100%
• Spinocerebellar Ataxia 17 79%
• TATA-Box Binding Protein 60%
• indole 54%
• Neuronal Outgrowth 48%
• polyglutamine 34%
• Death Domain 7%
• Molecular Chaperones 6%
• Purkinje Cells 5%
• Cytochromes c 5%
• Neuroprotection 5%
• Heat-Shock Proteins 5%
• Neuroprotective Agents 5%
• Transgenic Mice 4%
• Caspase 3 4%
• Reactive Oxygen Species 4%
• Cell Death 4%
• Proteins 3%
• Apoptosis 3%
• Genes 2%
• Therapeutics 1%

Chemical Compounds

• Indole 39%
• Protein 17%
• Neuroprotective 5%
• Cell Death 4%
• Agonist 4%
• Reactive Oxygen Metabolite 3%
• Cytochrome 3%
• Heat 3%