The effect of covalent immobilization of sialic acid on the removal of lipopolysaccharide and reactive oxygen species for polyethylene terephthalate

Jung Jhih Chang, Po Ju Lin, Yen Hsien Lee, Ming Chien Yang, Chiang-Ting Chien

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Polyethylene terephthalate (PET) was aminolyzed with 1,6-diaminohexane (DAH) and then sialic acid (NANA) was immobilized via amidation onto the surface. The surface concentration of NANA was determined by 2-thiobarbituric acid (TBA) test. The hemocompatibility of the resulting PET fabrics was evaluated based on complete blood count (CBC), coagulating times, and protein adsorption. The ability to remove lipopolysaccharide (LPS) was also determined. In addition, the effect of contacting NANA-immobilizing PET on the suppression of reactive oxygen species (ROS) production was measured by the chemiluminescence (CL) method. The results show that by immobilizing NANA onto PET, the adhesion of platelet (PLt) was reduced, and oxidative stress was suppressed. The level of LPS was also greatly reduced.

Original languageEnglish
Pages (from-to)1872-1878
Number of pages7
JournalPolymers for Advanced Technologies
Volume22
Issue number12
DOIs
Publication statusPublished - 2011 Dec 1

Keywords

  • Hemocompatibility
  • Lipopolysaccharide
  • Polyethylene terephthalate
  • Reactive oxygen species (ROS)
  • Sialic acid

ASJC Scopus subject areas

  • Polymers and Plastics

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