The Changes of Cerebral Morphology Related to Aging in Taiwanese Population

Hsiao Lan Sharon Wang, Rongjun Yu, Yu Tzu Wu, Wen Yuan Lee, Ming Fan Lin, Chia Yuan Chen, Ein Yiao Shen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A cross-sectional study with the 3-dimensional (3D) MRI reconstruction technique was conducted to investigate cerebral complexity changes related to age differences in native Taiwanese population. In our sample of 85 participants aged between 25 and 81, age was associated with gradual ventricular expansion. A nonlinear quadratic relationship between white matter volume and age was found overall in the brain. Widespread age-related reduction in white matter was detected from late adulthood onwards. However, no significant age-related changes in the cortex and whole brain volume were determined throughout adulthood. These findings provided information in describing brain structural complexity, which might in the future serve as an objective diagnostic index or as a predictive parameter for neurological diseases. Our method then may be used for cross-cultural longitudinal studies to evaluate the effect of disease, environment and aging on the brain.

Original languageEnglish
Article numbere55241
JournalPLoS ONE
Volume8
Issue number1
DOIs
Publication statusPublished - 2013 Jan 30

Fingerprint

Brain
Aging of materials
brain
Population
adulthood
Magnetic resonance imaging
Longitudinal Studies
longitudinal studies
cross-sectional studies
Cross-Sectional Studies
cortex
methodology
White Matter
sampling

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

The Changes of Cerebral Morphology Related to Aging in Taiwanese Population. / Wang, Hsiao Lan Sharon; Yu, Rongjun; Wu, Yu Tzu; Lee, Wen Yuan; Lin, Ming Fan; Chen, Chia Yuan; Shen, Ein Yiao.

In: PLoS ONE, Vol. 8, No. 1, e55241, 30.01.2013.

Research output: Contribution to journalArticle

Wang, Hsiao Lan Sharon ; Yu, Rongjun ; Wu, Yu Tzu ; Lee, Wen Yuan ; Lin, Ming Fan ; Chen, Chia Yuan ; Shen, Ein Yiao. / The Changes of Cerebral Morphology Related to Aging in Taiwanese Population. In: PLoS ONE. 2013 ; Vol. 8, No. 1.
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