The bi-metallic MOF-919 (Fe-Cu) nanozyme capable of bifunctional enzyme-mimicking catalytic activity

Sivasankar Kulandaivel; Chia Her Lin; Yi Chun Yeh

doi:10.1039/d1cc05908d

The bi-metallic MOF-919 (Fe-Cu) nanozyme capable of bifunctional enzyme-mimicking catalytic activity

Sivasankar Kulandaivel, Chia Her Lin^*, Yi Chun Yeh^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

In this study, we report on a bi-metal organic framework, MOF-919 (Fe-Cu), capable of bifunctional-enzyme mimicking activity with oxidase- and peroxidase-like activities. The catalytic activities were examined by using o-phenylenediamine (OPD) as a chromogenic substrate to study oxidase- and peroxidase-like mimetics. Based on our findings, we developed a simple epinephrine colorimetric biosensor with a broad linear range (1-100 μM) and a low detection limit (0.298 μM). This approach provides evidence for transition metal-based pristine bi-metallic MOFs capable of reproducing both oxidase-peroxidase properties, which could be applied as new nanosensors.

Original language	English
Pages (from-to)	569-572
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	4
DOIs	https://doi.org/10.1039/d1cc05908d
Publication status	Published - 2022 Jan 14

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "In this study, we report on a bi-metal organic framework, MOF-919 (Fe-Cu), capable of bifunctional-enzyme mimicking activity with oxidase- and peroxidase-like activities. The catalytic activities were examined by using o-phenylenediamine (OPD) as a chromogenic substrate to study oxidase- and peroxidase-like mimetics. Based on our findings, we developed a simple epinephrine colorimetric biosensor with a broad linear range (1-100 μM) and a low detection limit (0.298 μM). This approach provides evidence for transition metal-based pristine bi-metallic MOFs capable of reproducing both oxidase-peroxidase properties, which could be applied as new nanosensors.",

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AU - Lin, Chia Her

AU - Yeh, Yi Chun

N1 - Publisher Copyright: © The Royal Society of Chemistry.

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N2 - In this study, we report on a bi-metal organic framework, MOF-919 (Fe-Cu), capable of bifunctional-enzyme mimicking activity with oxidase- and peroxidase-like activities. The catalytic activities were examined by using o-phenylenediamine (OPD) as a chromogenic substrate to study oxidase- and peroxidase-like mimetics. Based on our findings, we developed a simple epinephrine colorimetric biosensor with a broad linear range (1-100 μM) and a low detection limit (0.298 μM). This approach provides evidence for transition metal-based pristine bi-metallic MOFs capable of reproducing both oxidase-peroxidase properties, which could be applied as new nanosensors.

AB - In this study, we report on a bi-metal organic framework, MOF-919 (Fe-Cu), capable of bifunctional-enzyme mimicking activity with oxidase- and peroxidase-like activities. The catalytic activities were examined by using o-phenylenediamine (OPD) as a chromogenic substrate to study oxidase- and peroxidase-like mimetics. Based on our findings, we developed a simple epinephrine colorimetric biosensor with a broad linear range (1-100 μM) and a low detection limit (0.298 μM). This approach provides evidence for transition metal-based pristine bi-metallic MOFs capable of reproducing both oxidase-peroxidase properties, which could be applied as new nanosensors.

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The bi-metallic MOF-919 (Fe-Cu) nanozyme capable of bifunctional enzyme-mimicking catalytic activity

Abstract

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