TY - JOUR
T1 - The bi-metallic MOF-919 (Fe-Cu) nanozyme capable of bifunctional enzyme-mimicking catalytic activity
AU - Kulandaivel, Sivasankar
AU - Lin, Chia Her
AU - Yeh, Yi Chun
N1 - Funding Information:
The authors would like to thank the Ministry of Science and Technology, Taiwan for the financial support through grants MOST 107-2113-M-003-013-MY3, 110-2113-M-003-009-, and 110-2113-M-003-011-MY3. Dr Sivasankar Kulandaivel gratefully acknowledges the Ministry of Science and Technology, Taiwan for the postdoctoral fellowship and MOST grant 110-2811-M-003-512. The financial support from the National Taiwan Normal University (NTNU) within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan is gratefully acknowledged.
Publisher Copyright:
© The Royal Society of Chemistry.
PY - 2022/1/14
Y1 - 2022/1/14
N2 - In this study, we report on a bi-metal organic framework, MOF-919 (Fe-Cu), capable of bifunctional-enzyme mimicking activity with oxidase- and peroxidase-like activities. The catalytic activities were examined by using o-phenylenediamine (OPD) as a chromogenic substrate to study oxidase- and peroxidase-like mimetics. Based on our findings, we developed a simple epinephrine colorimetric biosensor with a broad linear range (1-100 μM) and a low detection limit (0.298 μM). This approach provides evidence for transition metal-based pristine bi-metallic MOFs capable of reproducing both oxidase-peroxidase properties, which could be applied as new nanosensors.
AB - In this study, we report on a bi-metal organic framework, MOF-919 (Fe-Cu), capable of bifunctional-enzyme mimicking activity with oxidase- and peroxidase-like activities. The catalytic activities were examined by using o-phenylenediamine (OPD) as a chromogenic substrate to study oxidase- and peroxidase-like mimetics. Based on our findings, we developed a simple epinephrine colorimetric biosensor with a broad linear range (1-100 μM) and a low detection limit (0.298 μM). This approach provides evidence for transition metal-based pristine bi-metallic MOFs capable of reproducing both oxidase-peroxidase properties, which could be applied as new nanosensors.
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U2 - 10.1039/d1cc05908d
DO - 10.1039/d1cc05908d
M3 - Article
C2 - 34913054
AN - SCOPUS:85122928804
SN - 1359-7345
VL - 58
SP - 569
EP - 572
JO - Chemical Communications
JF - Chemical Communications
IS - 4
ER -