The aqueous extract of Prunella vulgaris suppresses cell invasion and migration in human liver cancer cells by attenuating matrix metalloproteinases

Seung Hum Kim; Chung Yueh Huang; Cheng Yu Tsai; Shu Yi Lu; Chien Chih Chiu; Kang Fang

doi:10.1142/S0192415X12500486

The aqueous extract of Prunella vulgaris suppresses cell invasion and migration in human liver cancer cells by attenuating matrix metalloproteinases

Seung Hum Kim, Chung Yueh Huang, Cheng Yu Tsai, Shu Yi Lu, Chien Chih Chiu, Kang Fang^*

^*Corresponding author for this work

Department of Life Science

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

The mechanism of action of Prunella vulgaris L. (PV) affecting cell migration and invasion of human liver cancer cells remains unknown. In this work we showed that the aqueous extract of PV affected migration and invasion of human liver carcinoma cells by inhibiting activities of metalloproteases, MMP-2 and MMP-9, without affecting cell viabilities. We further showed that PV suppressed migration through attenuation of enzymatic activities of MMP-9 and MMP-2 at transcriptional levels and the effects can be correlated with the status of p53 in hepatocarcinoma cells. This work provides a new dimension of understanding on Prunella vulgaris in restraining migration and invasion in human liver cancer cells.

Original language	English
Pages (from-to)	643-656
Number of pages	14
Journal	American Journal of Chinese Medicine
Volume	40
Issue number	3
DOIs	https://doi.org/10.1142/S0192415X12500486
Publication status	Published - 2012

Keywords

Human Hepatocarcinoma Cells
Invasion and Metastasis
Prunella vulgaris

ASJC Scopus subject areas

Complementary and alternative medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1142/S0192415X12500486

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title = "The aqueous extract of Prunella vulgaris suppresses cell invasion and migration in human liver cancer cells by attenuating matrix metalloproteinases",

abstract = "The mechanism of action of Prunella vulgaris L. (PV) affecting cell migration and invasion of human liver cancer cells remains unknown. In this work we showed that the aqueous extract of PV affected migration and invasion of human liver carcinoma cells by inhibiting activities of metalloproteases, MMP-2 and MMP-9, without affecting cell viabilities. We further showed that PV suppressed migration through attenuation of enzymatic activities of MMP-9 and MMP-2 at transcriptional levels and the effects can be correlated with the status of p53 in hepatocarcinoma cells. This work provides a new dimension of understanding on Prunella vulgaris in restraining migration and invasion in human liver cancer cells.",

keywords = "Human Hepatocarcinoma Cells, Invasion and Metastasis, Prunella vulgaris",

author = "Kim, {Seung Hum} and Huang, {Chung Yueh} and Tsai, {Cheng Yu} and Lu, {Shu Yi} and Chiu, {Chien Chih} and Kang Fang",

note = "Funding Information: The work was supported in parts by grants from the Committee of Chinese Medicine and Pharmacy, Department of Health, Executive Yuan (CCMP96-RD-205) and National Taiwan Normal University (99D3-1), Taipei, Taiwan, ROC.",

year = "2012",

doi = "10.1142/S0192415X12500486",

language = "English",

volume = "40",

pages = "643--656",

journal = "American Journal of Chinese Medicine",

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T1 - The aqueous extract of Prunella vulgaris suppresses cell invasion and migration in human liver cancer cells by attenuating matrix metalloproteinases

AU - Kim, Seung Hum

AU - Huang, Chung Yueh

AU - Tsai, Cheng Yu

AU - Lu, Shu Yi

AU - Chiu, Chien Chih

AU - Fang, Kang

N1 - Funding Information: The work was supported in parts by grants from the Committee of Chinese Medicine and Pharmacy, Department of Health, Executive Yuan (CCMP96-RD-205) and National Taiwan Normal University (99D3-1), Taipei, Taiwan, ROC.

PY - 2012

Y1 - 2012

N2 - The mechanism of action of Prunella vulgaris L. (PV) affecting cell migration and invasion of human liver cancer cells remains unknown. In this work we showed that the aqueous extract of PV affected migration and invasion of human liver carcinoma cells by inhibiting activities of metalloproteases, MMP-2 and MMP-9, without affecting cell viabilities. We further showed that PV suppressed migration through attenuation of enzymatic activities of MMP-9 and MMP-2 at transcriptional levels and the effects can be correlated with the status of p53 in hepatocarcinoma cells. This work provides a new dimension of understanding on Prunella vulgaris in restraining migration and invasion in human liver cancer cells.

AB - The mechanism of action of Prunella vulgaris L. (PV) affecting cell migration and invasion of human liver cancer cells remains unknown. In this work we showed that the aqueous extract of PV affected migration and invasion of human liver carcinoma cells by inhibiting activities of metalloproteases, MMP-2 and MMP-9, without affecting cell viabilities. We further showed that PV suppressed migration through attenuation of enzymatic activities of MMP-9 and MMP-2 at transcriptional levels and the effects can be correlated with the status of p53 in hepatocarcinoma cells. This work provides a new dimension of understanding on Prunella vulgaris in restraining migration and invasion in human liver cancer cells.

KW - Human Hepatocarcinoma Cells

KW - Invasion and Metastasis

KW - Prunella vulgaris

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DO - 10.1142/S0192415X12500486

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JO - American Journal of Chinese Medicine

JF - American Journal of Chinese Medicine

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The aqueous extract of Prunella vulgaris suppresses cell invasion and migration in human liver cancer cells by attenuating matrix metalloproteinases

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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