The aqueous extract of Prunella vulgaris suppresses cell invasion and migration in human liver cancer cells by attenuating matrix metalloproteinases

Seung Hum Kim, Chung Yueh Huang, Cheng Yu Tsai, Shu Yi Lu, Chien Chih Chiu, Kang Fang

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The mechanism of action of Prunella vulgaris L. (PV) affecting cell migration and invasion of human liver cancer cells remains unknown. In this work we showed that the aqueous extract of PV affected migration and invasion of human liver carcinoma cells by inhibiting activities of metalloproteases, MMP-2 and MMP-9, without affecting cell viabilities. We further showed that PV suppressed migration through attenuation of enzymatic activities of MMP-9 and MMP-2 at transcriptional levels and the effects can be correlated with the status of p53 in hepatocarcinoma cells. This work provides a new dimension of understanding on Prunella vulgaris in restraining migration and invasion in human liver cancer cells.

Original languageEnglish
Pages (from-to)643-656
Number of pages14
JournalAmerican Journal of Chinese Medicine
Volume40
Issue number3
DOIs
Publication statusPublished - 2012 May 31

Fingerprint

Prunella
Liver Neoplasms
Matrix Metalloproteinases
Cell Movement
Metalloproteases
Hepatocellular Carcinoma
Cell Survival

Keywords

  • Human Hepatocarcinoma Cells
  • Invasion and Metastasis
  • Prunella vulgaris

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

The aqueous extract of Prunella vulgaris suppresses cell invasion and migration in human liver cancer cells by attenuating matrix metalloproteinases. / Kim, Seung Hum; Huang, Chung Yueh; Tsai, Cheng Yu; Lu, Shu Yi; Chiu, Chien Chih; Fang, Kang.

In: American Journal of Chinese Medicine, Vol. 40, No. 3, 31.05.2012, p. 643-656.

Research output: Contribution to journalArticle

@article{c64aba26f21847cf93b4dbf25ce7c948,
title = "The aqueous extract of Prunella vulgaris suppresses cell invasion and migration in human liver cancer cells by attenuating matrix metalloproteinases",
abstract = "The mechanism of action of Prunella vulgaris L. (PV) affecting cell migration and invasion of human liver cancer cells remains unknown. In this work we showed that the aqueous extract of PV affected migration and invasion of human liver carcinoma cells by inhibiting activities of metalloproteases, MMP-2 and MMP-9, without affecting cell viabilities. We further showed that PV suppressed migration through attenuation of enzymatic activities of MMP-9 and MMP-2 at transcriptional levels and the effects can be correlated with the status of p53 in hepatocarcinoma cells. This work provides a new dimension of understanding on Prunella vulgaris in restraining migration and invasion in human liver cancer cells.",
keywords = "Human Hepatocarcinoma Cells, Invasion and Metastasis, Prunella vulgaris",
author = "Kim, {Seung Hum} and Huang, {Chung Yueh} and Tsai, {Cheng Yu} and Lu, {Shu Yi} and Chiu, {Chien Chih} and Kang Fang",
year = "2012",
month = "5",
day = "31",
doi = "10.1142/S0192415X12500486",
language = "English",
volume = "40",
pages = "643--656",
journal = "American Journal of Chinese Medicine",
issn = "0192-415X",
publisher = "World Scientific Publishing Co. Pte Ltd",
number = "3",

}

TY - JOUR

T1 - The aqueous extract of Prunella vulgaris suppresses cell invasion and migration in human liver cancer cells by attenuating matrix metalloproteinases

AU - Kim, Seung Hum

AU - Huang, Chung Yueh

AU - Tsai, Cheng Yu

AU - Lu, Shu Yi

AU - Chiu, Chien Chih

AU - Fang, Kang

PY - 2012/5/31

Y1 - 2012/5/31

N2 - The mechanism of action of Prunella vulgaris L. (PV) affecting cell migration and invasion of human liver cancer cells remains unknown. In this work we showed that the aqueous extract of PV affected migration and invasion of human liver carcinoma cells by inhibiting activities of metalloproteases, MMP-2 and MMP-9, without affecting cell viabilities. We further showed that PV suppressed migration through attenuation of enzymatic activities of MMP-9 and MMP-2 at transcriptional levels and the effects can be correlated with the status of p53 in hepatocarcinoma cells. This work provides a new dimension of understanding on Prunella vulgaris in restraining migration and invasion in human liver cancer cells.

AB - The mechanism of action of Prunella vulgaris L. (PV) affecting cell migration and invasion of human liver cancer cells remains unknown. In this work we showed that the aqueous extract of PV affected migration and invasion of human liver carcinoma cells by inhibiting activities of metalloproteases, MMP-2 and MMP-9, without affecting cell viabilities. We further showed that PV suppressed migration through attenuation of enzymatic activities of MMP-9 and MMP-2 at transcriptional levels and the effects can be correlated with the status of p53 in hepatocarcinoma cells. This work provides a new dimension of understanding on Prunella vulgaris in restraining migration and invasion in human liver cancer cells.

KW - Human Hepatocarcinoma Cells

KW - Invasion and Metastasis

KW - Prunella vulgaris

UR - http://www.scopus.com/inward/record.url?scp=84861486757&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861486757&partnerID=8YFLogxK

U2 - 10.1142/S0192415X12500486

DO - 10.1142/S0192415X12500486

M3 - Article

VL - 40

SP - 643

EP - 656

JO - American Journal of Chinese Medicine

JF - American Journal of Chinese Medicine

SN - 0192-415X

IS - 3

ER -