Abstract
Copper catalyzed C-terminal and N-terminal attack of 2-alkynylanilines to 2-iodobenzamides afforded isoindolinones and 1,2-disubstituted indoles, respectively. Further, the isoindolinone derivatives were converted to spiro fused isoindolinone-indolines utilizing a halonium ion mediated strategy using NBS/TCC in the presence of acetic anhydride. Also, the ortho effect of the amide group in 2-iodobenzamide has been successfully applied for the synthesis of 1,2-disubstituted indoles.
| Original language | English |
|---|---|
| Pages (from-to) | 74845-74858 |
| Number of pages | 14 |
| Journal | RSC Advances |
| Volume | 6 |
| Issue number | 78 |
| DOIs | |
| Publication status | Published - 2016 Jan 1 |
ASJC Scopus subject areas
- Chemistry(all)
- Chemical Engineering(all)
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Villuri, B. K., Kotipalli, T., Kavala, V., Ichake, S. S., Bandi, V., Kuo, C. W., & Yao, C. F. (2016). Synthesis of spiro isoindolinone-indolines and 1,2-disubstituted indoles from 2-iodobenzamide derivatives. RSC Advances, 6(78), 74845-74858. https://doi.org/10.1039/c6ra15002k