Synthesis of pyrrole derivatives mediated by dicobalthexacarbonyl

Jeng Long Wang*, Chuen Her Ueng, Ming Chang P. Yeh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Addition of α- and β-amino acid derivatives to the cobalt stabilized propargylic cation 2 gives dicobalthexacarbonyl complexes with an amino acid derivative at the propargyl position. Oxidation of the resulting complexes with Fe(III) produces propargyl amines 4. Intramolecular cyclization of 4 with LDA followed by oxidation of the crude product with DDQ affords pyrrole derivatives as the major products.

Original languageEnglish
Pages (from-to)2823-2826
Number of pages4
JournalTetrahedron Letters
Issue number16
Publication statusPublished - 1995 Apr 17

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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