Synthesis of Pyrido[2,3-b]indoles via Brønsted-Acid-Promoted Decarboxylative Annulation of 3-Bromopropenals and Ethyl 2-Amino-1H-indole-3-carboxylates

Tang Hao Yang; Veerababurao Kavala; Chun Wei Kuo; Ching Fa Yao

doi:10.1002/ajoc.202000175

Synthesis of Pyrido[2,3-b]indoles via Brønsted-Acid-Promoted Decarboxylative Annulation of 3-Bromopropenals and Ethyl 2-Amino-1H-indole-3-carboxylates

Tang Hao Yang
, Veerababurao Kavala
, Chun Wei Kuo
, Ching Fa Yao^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The present methodology describes a versatile pathway to furnish α-carbolines from relatively stable 2-amino indole derivatives and 3-bromopropenal. High substrate tolerance, nonmetallic, more efficient, and mild reaction conditions are important aspects.

Original language	English
Pages (from-to)	1053-1058
Number of pages	6
Journal	Asian Journal of Organic Chemistry
Volume	9
Issue number	7
DOIs	https://doi.org/10.1002/ajoc.202000175
Publication status	Published - 2020 Jul 1

Keywords

3-bromopropenal
Brønsted
decarboxylative annulation
pyrido[2,3-b]indoles

ASJC Scopus subject areas

Organic Chemistry

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10.1002/ajoc.202000175

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@article{22754afbc9714a0d985615373ad5a6a9,

title = "Synthesis of Pyrido[2,3-b]indoles via Br{\o}nsted-Acid-Promoted Decarboxylative Annulation of 3-Bromopropenals and Ethyl 2-Amino-1H-indole-3-carboxylates",

abstract = "The present methodology describes a versatile pathway to furnish α-carbolines from relatively stable 2-amino indole derivatives and 3-bromopropenal. High substrate tolerance, nonmetallic, more efficient, and mild reaction conditions are important aspects.",

keywords = "3-bromopropenal, Br{\o}nsted, decarboxylative annulation, pyrido[2,3-b]indoles",

author = "Yang, \{Tang Hao\} and Veerababurao Kavala and Kuo, \{Chun Wei\} and Yao, \{Ching Fa\}",

note = "Publisher Copyright: {\textcopyright} 2020 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2020",

month = jul,

day = "1",

doi = "10.1002/ajoc.202000175",

language = "English",

volume = "9",

pages = "1053--1058",

journal = "Asian Journal of Organic Chemistry",

issn = "2193-5807",

publisher = "John Wiley and Sons Inc.",

number = "7",

}

TY - JOUR

T1 - Synthesis of Pyrido[2,3-b]indoles via Brønsted-Acid-Promoted Decarboxylative Annulation of 3-Bromopropenals and Ethyl 2-Amino-1H-indole-3-carboxylates

AU - Yang, Tang Hao

AU - Kavala, Veerababurao

AU - Kuo, Chun Wei

AU - Yao, Ching Fa

PY - 2020/7/1

Y1 - 2020/7/1

N2 - The present methodology describes a versatile pathway to furnish α-carbolines from relatively stable 2-amino indole derivatives and 3-bromopropenal. High substrate tolerance, nonmetallic, more efficient, and mild reaction conditions are important aspects.

AB - The present methodology describes a versatile pathway to furnish α-carbolines from relatively stable 2-amino indole derivatives and 3-bromopropenal. High substrate tolerance, nonmetallic, more efficient, and mild reaction conditions are important aspects.

KW - 3-bromopropenal

KW - Brønsted

KW - decarboxylative annulation

KW - pyrido[2,3-b]indoles

UR - https://www.scopus.com/pages/publications/85085004519

UR - https://www.scopus.com/pages/publications/85085004519#tab=citedBy

U2 - 10.1002/ajoc.202000175

DO - 10.1002/ajoc.202000175

M3 - Article

AN - SCOPUS:85085004519

SN - 2193-5807

VL - 9

SP - 1053

EP - 1058

JO - Asian Journal of Organic Chemistry

JF - Asian Journal of Organic Chemistry

IS - 7

ER -

Synthesis of Pyrido[2,3-b]indoles via Brønsted-Acid-Promoted Decarboxylative Annulation of 3-Bromopropenals and Ethyl 2-Amino-1H-indole-3-carboxylates

Abstract

Keywords

ASJC Scopus subject areas

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