Synthesis of perhydroisoquinoline derivatives mediated by (η6-arene)Cr(CO)3 complexes

Ming Chang P. Yeh; Chong Nan Chuang; Chun Hsiang Yiu

doi:10.1016/S0040-4039(97)01731-0

Synthesis of perhydroisoquinoline derivatives mediated by (η⁶-arene)Cr(CO)₃ complexes

Ming Chang P. Yeh, Chong Nan Chuang, Chun Hsiang Yiu

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Reaction of lithium hexamethyldisilazide (LHMDS) with (η⁶-arene)Cr(CO)₃ complexes bearing a β-alaninenitrile moiety gives tetrahydroisoquinoline derivatives as the major products after oxidation of the reaction intermediate, whereas protonation of the reaction intermediates produces hexahydroisoquinoline as the major products.

Original language	English
Pages (from-to)	7387-7390
Number of pages	4
Journal	Tetrahedron Letters
Volume	38
Issue number	42
DOIs	https://doi.org/10.1016/S0040-4039(97)01731-0
Publication status	Published - 1997 Oct 20

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(97)01731-0

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title = "Synthesis of perhydroisoquinoline derivatives mediated by (η6-arene)Cr(CO)3 complexes",

abstract = "Reaction of lithium hexamethyldisilazide (LHMDS) with (η6-arene)Cr(CO)3 complexes bearing a β-alaninenitrile moiety gives tetrahydroisoquinoline derivatives as the major products after oxidation of the reaction intermediate, whereas protonation of the reaction intermediates produces hexahydroisoquinoline as the major products.",

author = "Yeh, {Ming Chang P.} and Chuang, {Chong Nan} and Yiu, {Chun Hsiang}",

note = "Funding Information: Acknowledgements: This research was supported by a grant from the National Science Council of Republic of China (Grant No. NSC 84-2113-M-003-005).",

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T1 - Synthesis of perhydroisoquinoline derivatives mediated by (η6-arene)Cr(CO)3 complexes

AU - Yeh, Ming Chang P.

AU - Chuang, Chong Nan

AU - Yiu, Chun Hsiang

N1 - Funding Information: Acknowledgements: This research was supported by a grant from the National Science Council of Republic of China (Grant No. NSC 84-2113-M-003-005).

PY - 1997/10/20

Y1 - 1997/10/20

N2 - Reaction of lithium hexamethyldisilazide (LHMDS) with (η6-arene)Cr(CO)3 complexes bearing a β-alaninenitrile moiety gives tetrahydroisoquinoline derivatives as the major products after oxidation of the reaction intermediate, whereas protonation of the reaction intermediates produces hexahydroisoquinoline as the major products.

AB - Reaction of lithium hexamethyldisilazide (LHMDS) with (η6-arene)Cr(CO)3 complexes bearing a β-alaninenitrile moiety gives tetrahydroisoquinoline derivatives as the major products after oxidation of the reaction intermediate, whereas protonation of the reaction intermediates produces hexahydroisoquinoline as the major products.

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U2 - 10.1016/S0040-4039(97)01731-0

DO - 10.1016/S0040-4039(97)01731-0

M3 - Article

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VL - 38

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EP - 7390

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 42

ER -

Synthesis of perhydroisoquinoline derivatives mediated by (η⁶-arene)Cr(CO)₃ complexes

Abstract

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