Synthesis of perhydroisoquinoline derivatives mediated by (η6-arene)Cr(CO)3 complexes

Ming Chang P. Yeh, Chong Nan Chuang, Chun Hsiang Yiu

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Reaction of lithium hexamethyldisilazide (LHMDS) with (η6-arene)Cr(CO)3 complexes bearing a β-alaninenitrile moiety gives tetrahydroisoquinoline derivatives as the major products after oxidation of the reaction intermediate, whereas protonation of the reaction intermediates produces hexahydroisoquinoline as the major products.

Original languageEnglish
Pages (from-to)7387-7390
Number of pages4
JournalTetrahedron Letters
Issue number42
Publication statusPublished - 1997 Oct 20

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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