A highly diastereoselective method for the synthesis of novel spiro-tetrahydroquinoline derivatives is reported here, using a one-pot reaction method. All compounds were characterized by1 H-nuclear magnetic resonance (NMR) and mass spectroscopy, and their stereo configurations were confirmed by X-ray analysis. These activities of these derivatives were then tested in human keratocyte cells. The responses of cells to treatment with selected compounds were studied using scratch analysis, and the compounds were tested in a mouse excision wound model. Three of the derivatives demonstrated significant wound-healing activities.
- One-pot reaction
- Wound healing
ASJC Scopus subject areas
- Molecular Biology
- Computer Science Applications
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry
FingerprintDive into the research topics of 'Synthesis of novel spiro-tetrahydroquinoline derivatives and evaluation of their pharmacological effects on wound healing'. Together they form a unique fingerprint.
Liou, Y. (Contributor), Lin, Y. (Contributor), Wang, K. (Contributor), Yang, J. (Contributor), Jang, Y. (Contributor), Lin, W. (Contributor), Wu, Y. (Contributor) & Wang, K. (Contributor), Cambridge Crystallographic Data Centre, 2021