Synthesis of novel spiro-tetrahydroquinoline derivatives and evaluation of their pharmacological effects on wound healing

Yan Cheng Liou, Yan An Lin, Ke Wang, Juan Cheng Yang, Yeong Jiunn Jang, Wenwei Lin, Yang Chang Wu

Research output: Contribution to journalArticlepeer-review

Abstract

A highly diastereoselective method for the synthesis of novel spiro-tetrahydroquinoline derivatives is reported here, using a one-pot reaction method. All compounds were characterized by1 H-nuclear magnetic resonance (NMR) and mass spectroscopy, and their stereo configurations were confirmed by X-ray analysis. These activities of these derivatives were then tested in human keratocyte cells. The responses of cells to treatment with selected compounds were studied using scratch analysis, and the compounds were tested in a mouse excision wound model. Three of the derivatives demonstrated significant wound-healing activities.

Original languageEnglish
Article number6251
JournalInternational journal of molecular sciences
Volume22
Issue number12
DOIs
Publication statusPublished - 2021 Jun 2

Keywords

  • 1,3-indandione
  • One-pot reaction
  • Spiro-tetrahydroquinoline
  • Tetrahydroquinoline
  • Wound healing

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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