Synthesis of Multifunctional Alkenes from Substituted Acrylates and Aldehydes via Phosphine-Catalyzed Wittig Reaction

Yi Ling Tsai, Wenwei Lin

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

An efficient synthesis of multifunctional alkenes starting from substituted acrylates and aldehydes has been developed via phosphine-catalyzed Wittig reactions. The reactions proceed smoothly even under mild conditions (30-60°C) via a phosphine/phosphine oxide catalytic cycle using phenyl silane as the reducing agent. According to this simple protocol, the desired products are obtained in moderate to excellent yields as single stereoisomers.

Original languageEnglish
Pages (from-to)1040-1043
Number of pages4
JournalAsian Journal of Organic Chemistry
Volume4
Issue number10
DOIs
Publication statusPublished - 2015 Oct 1

Keywords

  • Acrylates
  • Alkenes
  • Wittig reaction
  • Ylides
  • Zwitterions

ASJC Scopus subject areas

  • Organic Chemistry

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