Abstract
A Bu3P-mediated mild and efficient synthesis of multi-functional alkenes has been described starting from substituted acrylate with aldehydes. In situ generated zwitterionic intermediates underwent proton-exchange to afford ylide intermediates, which were trapped by corresponding aldehydes providing the products in up to 92% yield with complete E-stereoselectivity. Further derivatization of the products was performed to furnish functional pyridazinones.
Original language | English |
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Pages (from-to) | 5038-5045 |
Number of pages | 8 |
Journal | Tetrahedron |
Volume | 70 |
Issue number | 34 |
DOIs | |
Publication status | Published - 2014 Aug 26 |
Keywords
- Cyclopropane
- Multi-functional alkene
- Phosphorus ylide
- Pyridazinone
- Wittig reaction
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry