Synthesis of multi-functional alkenes via Wittig reaction with a new-type of phosphorus ylides

Yi Ling Tsai, Siang En Syu, Shu Mei Yang, Utpal Das, Yu Shiou Fan, Chia Jui Lee, Wenwei Lin

Research output: Contribution to journalArticle

10 Citations (Scopus)


A Bu3P-mediated mild and efficient synthesis of multi-functional alkenes has been described starting from substituted acrylate with aldehydes. In situ generated zwitterionic intermediates underwent proton-exchange to afford ylide intermediates, which were trapped by corresponding aldehydes providing the products in up to 92% yield with complete E-stereoselectivity. Further derivatization of the products was performed to furnish functional pyridazinones.

Original languageEnglish
Pages (from-to)5038-5045
Number of pages8
Issue number34
Publication statusPublished - 2014 Aug 26



  • Cyclopropane
  • Multi-functional alkene
  • Phosphorus ylide
  • Pyridazinone
  • Wittig reaction

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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