Synthesis of isoxazoline N -oxides via [hydroxy(tosyloxy)iodo]benzene (HTIB)-mediated oxidative N-O coupling

Mustafa J. Raihan, Veerababurao Kavala, Pateliya Mujjamil Habib, Qiao Zhi Guan, Chun Wei Kuo, Ching Fa Yao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


An HTIB mediated oxidative N-O coupling strategy for the synthesis of some isoxazoline N-oxide derivatives from β-hydroxyketoximes is described, along with a comparative study of the efficiency of N-O coupling in two different solvents. A plausible mechanism for the conversion is proposed.

Original languageEnglish
Pages (from-to)424-434
Number of pages11
JournalJournal of Organic Chemistry
Issue number2
Publication statusPublished - 2011 Jan 21

ASJC Scopus subject areas

  • Organic Chemistry


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